Medical application of Shouhui bowel-relaxing capsule

A kind of use, the technology of aloe vera, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, applications, etc., can solve the problems that have not yet been researched or reported on Shouhui laxative capsules

Pending Publication Date: 2022-02-01
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no research or report on Shouhui Laxative Capsules in hangover relief

Method used

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  • Medical application of Shouhui bowel-relaxing capsule
  • Medical application of Shouhui bowel-relaxing capsule
  • Medical application of Shouhui bowel-relaxing capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Behavioral Effects of Shouhui Tongbian Capsules on Drunken Mice

[0029] ICR mice were purchased from Lunan Pharmaceutical Group Co., Ltd., experimental animal license number SYXK (Lu) 2018000.

[0030] 60 male ICR mice were randomly divided into 5 groups according to body weight, namely: blank control group, drunken model control group, low-dose Shouhui Tongbian capsule group, medium-dose Shouhui Tongbian capsule group, and Shouhui Tongbian capsule group. Capsule high-dose group, 12 in each group.

[0031] Food and water were fasted overnight before the experiment. Mice in the blank control group were given 10 mL / (kg bw) of distilled water;

[0032] The mice in the model group and the mice in the low-, medium-, and high-dose groups of Shouhui Tongbian Capsules were orally administered 10 mL / (kg·bw) of 50% (V / V) ethanol.

[0033] After 30 minutes, the mice in the blank control group and the mice in the model group were given 12 mL / (kg bw) of distilled water...

Embodiment 2

[0042] Example 2 Effect of Shouhui Tongbian Capsules on Memory Ability of Long-term Alcohol-impaired Mice

[0043] Forty-eight ICR mice were randomly divided into 4 groups, 12 in each group, which were blank control group, model control group, low-dose and high-dose Shouhui Tongbian Capsule groups.

[0044] Every day except the blank control group gavage purified water, other groups were gavage alcohol (45%) 0.01ml / g, 30min before gavage alcohol, Shouhui Tongbian Capsule low dose, high dose group gavage administration, The doses were 50 mg / kg and 200 mg / kg respectively; the model control group was given the same amount of purified water, and the blank control group was given the same amount of purified water for two consecutive weeks.

[0045] Afterwards, the water maze experiment was carried out, and the pool water was dyed black with ink to form a sharp contrast with the white mice to facilitate data collection. The experiment was carried out for 5 days, and the results of ...

Embodiment 3

[0051] Example 3 Effect of Shouhui Tongbian Capsules on Liver Alcohol Dehydrogenase Content

[0052] 48 Kunming mice, male, weighing 20±2g, were randomly divided into 4 groups according to body weight, 12 in each group. Food and water were not allowed for 12 hours before the experiment.

[0053] In addition to the blank control group, the mice in the model group, Shouhui Tongbian Capsule high-dose and low-dose groups were given 56° liquor, 0.05ml / 10g, for 14 days continuously, and the mice in each group were fed with standard feed during the modeling period , drinking water freely, and the blank control group was given normal saline.

[0054] From the first day, 1 hour after drinking, Shouhui Tongbian Capsules were intragastrically administered to the low-dose and high-dose groups of Shouhui Tongbian Capsules at 0.1ml / 10g, the doses were 50mg / kg and 200mg / kg respectively. The model control group was given the same amount of purified water, and the blank control group was giv...

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Abstract

The invention relates to a traditional Chinese medicine composition for dispelling effects of alcohol, belongs to the field of medicines, and particularly relates to an application of Shouhui bowel-relaxing capsule to preparation of a medicine for dispelling effects of alcohol. The researches show that the Shouhui bowel-relaxing capsule can shorten the sobering time and prolong the drunkenness latency period and attachment time, so that the Shouhui bowel-relaxing capsule can delay drunkenness of mice and help drunkenness mice to recover a normal state, and has a remarkable sobering effect. The Shouhui bowel-relaxing capsule has a good effect of improving the drunkenness state of experimental animals, has a remarkable effect of protecting the liver and the brain, and has a wide application prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for hangover and belongs to the field of medicine. It specifically relates to the application of Shouhui Tongbian Capsules in the preparation of antialcoholic drugs. Background technique [0002] my country is the birthplace of wine culture, and it is also the first country in the world to invent and study wine making. During the thousands of years of cultural development in China, a large number of wine cultures have been included. Alcohol is widely used in daily etiquette and social interaction, but heavy drinking is extremely harmful to the body and even leads to death. The World Health Organization pointed out that alcoholism is one of the world's number one public hazards. In developed countries, alcoholism, cardiovascular disease, and tumors are also known as three major public health problems. [0003] Alcohol is a common drink in daily life. Drinking alcohol on special occasi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A61P1/16A61P39/02A61P25/00A23L33/10A61K35/36
CPCA61K36/704A61K36/896A61K36/886A61K36/482A61K36/815A61K35/36A61K36/258A61K36/284A61K36/752A61P39/02A61P1/16A61P25/00A23L33/10A23V2002/00A61K2300/00A23V2200/334A23V2200/32A23V2200/322
Inventor 姜明敏孙成宏潘丽红
Owner SHANDONG NEWTIME PHARMA
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