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Biomarker group for predicting lung cancer

A biomarker and marker technology, applied in the field of biomarker panels for predicting lung cancer, can solve problems such as drug resistance and large side effects, and achieve the effect of high diagnostic sensitivity, specificity, and high diagnostic efficiency

Pending Publication Date: 2022-02-08
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI +1
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Problems solved by technology

However, due to the side effects of chemotherapy and radiotherapy, which will eventually lead to drug resistance, the average survival period of patients is less than 10 months

Method used

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  • Biomarker group for predicting lung cancer
  • Biomarker group for predicting lung cancer

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Embodiment Construction

[0063] Through extensive and in-depth research, the present invention studies genes strongly related to lung cancer based on the 11-gene EGFR gene network, and discovers a 3-gene characteristic genome. The present invention aims to make full use of the potential value of EGFR as a marker of lung cancer, so as to develop an effective characteristic gene combination to predict lung cancer and the prognosis of lung cancer. Differentially expressed genes associated with the 3-gene characteristic genome were found in the inventor's clinical database. From these differentially expressed genes, 25 characteristic genomes and multiple subgroups were constructed. These characteristic genomes are very effective in predicting lung cancer and the prognosis of lung cancer.

[0064] The term "and / or" as used herein in a phrase such as "A and / or B" is intended to include both A and B; A or B; A (alone); and B (alone). Likewise, the term "and / or" used in phrases such as "A, B, and / or C" is i...

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Abstract

The invention discloses a biomarker group for predicting lung cancer. The biomarker group is used for predicting lung cancer, has relatively high accuracy, sensitivity and specificity, and can be used for predicting prognosis of lung cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a biomarker group for predicting lung cancer. Background technique [0002] According to statistics, the morbidity and mortality of lung cancer have been high all over the world. Stage IV lung cancer has a five-year survival rate of only 1-9%, and causes more deaths than breast, pancreatic, colon, and prostate cancers combined (Testa U, Castelli G, Pelosi E. Lung Cancers : Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Ce11s [J]. Cancers (Basel), 2018, 10 (8).). According to the data estimated by the World Health Organization in 2020, in my country, the incidence rate of lung cancer ranks first among malignant tumors, and the number of new lung cancer cases is about 800,000. Chinese Medical Association Respiratory Branch Lung Cancer Group, Chinese Medical Doctor Association Respiratory Physician Branch Lung Cancer Working Committee. Chinese Expert Consens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/68G16B25/20G16H50/30
CPCC12Q1/6886G01N33/57423G01N33/68G16B25/20G16H50/30C12Q2600/158C12Q2600/118
Inventor 张帆杨承刚
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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