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miRNA markers related to active pulmonary tuberculosis and their application

A technology for active tuberculosis and markers, applied in the field of biomedicine, to achieve good stability, predict the risk of active tuberculosis, and improve the detection rate

Active Publication Date: 2022-05-06
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this application is to provide a miRNA marker related to active tuberculosis and its application, aiming to solve the problem that there is no related miRNA marker in the prior art that can accurately and quickly predict the risk of active tuberculosis

Method used

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  • miRNA markers related to active pulmonary tuberculosis and their application
  • miRNA markers related to active pulmonary tuberculosis and their application
  • miRNA markers related to active pulmonary tuberculosis and their application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] An application of a miRNA marker related to active pulmonary tuberculosis in the preparation of products for the early diagnosis of active pulmonary tuberculosis, wherein the product is selected from a system for predicting the risk of active pulmonary tuberculosis.

[0106] The system includes:

[0107] (1) Data acquisition unit: it is used to perform real-time fluorescence quantitative reaction based on Direct S-Poly(T) Plus to obtain the Ct value obtained from real-time fluorescence quantitative reaction of 17 different miRNA markers provided in Table 1.

[0108] The specific steps are as follows: including:

[0109] ① Collection and processing of plasma samples from subjects: 335 patients with active pulmonary tuberculosis, 260 healthy people, and 245 patients with non-tuberculous pneumonia were included in this example. The samples were tested by mixing 1 sample for every 5 samples, that is, 67 samples from patients with active pulmonary tuberculosis, 52 samples f...

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Abstract

This application relates to the field of biomedical technology, in particular to miRNA markers related to active tuberculosis and their applications, wherein the miRNA markers related to active tuberculosis include miR-451a, miR-25-3p, miR-425 ‑5p, miR‑1260b, miR‑1273g‑3p, miR‑30e‑5p, miR‑140‑3p, let‑7a‑5p, miR‑1290, miR‑491‑5p, miR‑3615, miR‑15a‑5p One or more of miR-21-3p, miR-424-5p, miR-1268a, miR-1301-3p, miR-345-5p, miR-572, miR-375, miR-151a-5p.

Description

technical field [0001] The application belongs to the field of biomedical technology, and in particular relates to a miRNA marker related to active pulmonary tuberculosis and its application. Background technique [0002] The gold standard for the diagnosis of active pulmonary tuberculosis and the evaluation of activity after treatment is etiological examination. However, for patients with active pulmonary tuberculosis (bacterium-negative pulmonary tuberculosis) with negative etiological examination, there is a lack of criteria for judgment, and a final judgment needs to be made by combining clinical manifestations, treatment history, and imaging. Many bacterium-negative pulmonary tuberculosis patients, especially those without special symptoms and signs, cannot receive effective treatment, delaying the best time for anti-tuberculosis treatment and increasing the risk of community transmission. Therefore, the development of new diagnostic techniques for active TB is critica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12Q1/6851C12N15/11G16H50/80
CPCC12Q1/6883C12Q1/6851G16H50/80C12Q2600/158C12Q2600/178C12Q2531/113C12Q2521/107C12Q2525/207C12Q2525/173C12Q2563/107C12Q2537/165
Inventor 陈心春胡云龙蔡毅张惠华杨浩
Owner SHENZHEN UNIV
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