Construction method of throat contact granuloma New Zealand rabbit animal model
A technology of animal model and construction method, which is applied in the field of laryngeal contact granuloma research, can solve the problems of inconvenient operation, poor fixation effect, and easy crushing of experimental rabbits, etc., and achieves the advantages of convenient method, guaranteed fixation effect, and increased fixation effect Effect
Pending Publication Date: 2022-04-05
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology
None of the above methods can simulate the natural course of gastric acid reflux, and the operation is inconvenient
[0004] In addition, in the process of constructing the New Zealand rabbit animal model of laryngeal contact granuloma, traditional fixation devices were used to fix the experimental rabbits, which had the problems of poor fixation effect and easy crushing of the limbs of the experimental rabbits
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[0046] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and through specific implementation methods.
[0047] Wherein, the accompanying drawings are only for illustrative purposes, showing only schematic diagrams, rather than physical drawings, and should not be construed as limitations on this patent; in order to better illustrate the embodiments of the present invention, some parts of the accompanying drawings will be omitted, Enlargement or reduction does not represent the size of the actual product; for those skilled in the art, it is understandable that certain known structures and their descriptions in the drawings may be omitted.
[0048] In the drawings of the embodiments of the present invention, the same or similar symbols correspond to the same or similar components; , "inner", "outer" and other indicated orientations or positional relationships are based on the orientations or positional ...
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The invention provides a method for constructing a throat contact granuloma New Zealand rabbit animal model, which mainly comprises the following operation steps of: preparing experimental animals, equipment and medicines, manufacturing an improved stomach tube, anesthetizing and fixing a New Zealand white rabbit, indwelling the improved stomach tube, mechanically damaging the cypripedium cartilage, and waking up the experimental rabbit. According to the constructed model, autologous gastric acid regurgitation of the New Zealand white rabbit is constructed by indwelling an improved stomach tube, the surface of the cypetenoid cartilage is damaged by using a microscopic laryngeal forceps under direct vision by virtue of an animal laryngoscope until the bone surface is exposed, and the animal model of the laryngeal contact granuloma is constructed by virtue of the combined action of the two factors. Throat regurgitation of gastric acid in a natural state is simulated by indwelling a stomach tube with side holes, and the pathogenesis of laryngeal contact granuloma is simulated by using an'cypetenoid cartilage injury + autologous throat regurgitation 'mode to construct an animal model, so that the method can be used for researching the pathogenesis of laryngeal contact granuloma diseases and related treatment; and a foundation is laid for constructing a laryngeal contact granuloma model by companion scholars.
Description
technical field [0001] The invention relates to the technical field of research on laryngeal contact granuloma, in particular to a method for constructing a New Zealand rabbit animal model of laryngeal contact granuloma. Background technique [0002] Laryngeal contact granuloma, also known as arytenoid cartilage granuloma and vocal cord granuloma, refers to the damage of the mucosa around the vocal cord process under the influence of various diseases and inducements, followed by inflammatory reactions, long-term ulceration, and then tissue Granuloma-like lesions formed by repeated proliferation belong to non-specific granuloma. The incidence of laryngeal contact granuloma accounts for about 0.9%-2.7% of voice diseases. The disease is difficult to cure and easy to relapse. The pathogenesis and treatment of laryngeal contact granuloma are the difficulties of current clinical and basic research. The etiology of laryngeal contact granuloma is complex. At present, its main etiol...
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IPC IPC(8): A01K67/02A61D3/00A61D7/00
Inventor 刘勇张鹏王芸芸张欣邱元正黄东海陈慧红申哲
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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