Cross-linked chitosan hydrogel stomach filling agent as well as preparation method and application thereof

A filler, chitosan technology, applied in the field of medical assistance, to achieve the effect of reducing pain

Pending Publication Date: 2022-04-19
北京华量引擎网络科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the hydrogel of the cross-linked carboxymethyl cellulose system tends to have a higher swelling ratio in neutral and weakly alkaline environments, and when used as a gastric filling agent, it cannot exert its maximum effect in the gastric environment

Method used

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  • Cross-linked chitosan hydrogel stomach filling agent as well as preparation method and application thereof
  • Cross-linked chitosan hydrogel stomach filling agent as well as preparation method and application thereof
  • Cross-linked chitosan hydrogel stomach filling agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0039] Embodiment 1~4, a kind of cross-linked chitosan hydrogel gastric filling agent and preparation method thereof

[0040] The formula of cross-linked chitosan hydrogel gastric filler is shown in table 1:

[0041] Table 1

[0042]

[0043] The preparation method of the crosslinked chitosan hydrogel gastric filler of embodiment 1~4, comprises the following steps:

[0044] S1. Dissolving the adipic acid in the corresponding parts by weight of the above-mentioned Examples 1 to 4 in an aqueous ethanol solution with a mass concentration of 50%, and preparing the mass fractions respectively to be 1.5% (Example 1) and 1.3% (Example 2) , 1.1% (embodiment 3), the solution A of 0.9% (embodiment 4);

[0045] S2. Add 5.8 parts by weight of N-hydroxysuccinimide (NHS) to the prepared solution A, continue to stir until completely dissolved to obtain a mixed solution, then add 30 parts by weight of chitosan to the mixed solution, The massfraction of chitosan in the mixed solution is 3%...

Embodiment 5

[0048] Embodiment 5, a kind of cross-linked chitosan hydrogel gastric filler and preparation method thereof

[0049] The formula (parts by weight) of cross-linked chitosan hydrogel gastric filler is as follows:

[0050] 10 parts of chitosan and 20 parts of adipic acid, the relative molecular mass of chitosan is 150kDa, and the degree of deacetylation of chitosan is 70%.

[0051] The preparation method of above-mentioned cross-linked chitosan hydrogel gastric filler comprises the following steps:

[0052] S1. Dissolving the above-mentioned adipic acid in corresponding parts by weight in an aqueous ethanol solution with a mass concentration of 40% to prepare a solution A with a mass fraction of 1%;

[0053] S2. Add 4.6 parts by weight of N-hydroxysuccinimide (NHS) to the prepared solution A, continue stirring until completely dissolved to obtain a mixed solution, then add 10 parts by weight of chitosan to the mixed solution, The massfraction of chitosan in the mixed solution i...

Embodiment 6

[0056] Embodiment 6, a kind of cross-linked chitosan hydrogel gastric filler and preparation method thereof

[0057] The formula (parts by weight) of cross-linked chitosan hydrogel gastric filler is as follows:

[0058] 40 parts of chitosan and 5 parts of adipic acid, the relative molecular mass of chitosan is 150kDa, and the degree of deacetylation of chitosan is 70%.

[0059] The preparation method of above-mentioned cross-linked chitosan hydrogel gastric filler comprises the following steps:

[0060] S1, dissolving the above-mentioned adipic acid in corresponding parts by weight in an aqueous ethanol solution with a mass concentration of 60%, and preparing a solution A with a mass fraction of 1%;

[0061] S2. Add 6.9 parts by weight of N-hydroxysuccinimide (NHS) to the prepared solution A, continue to stir until completely dissolved to obtain a mixed solution, then add 40 parts by weight of chitosan to the mixed solution, The massfraction of chitosan in the mixed solution...

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Abstract

The invention relates to the technical field of medical assistance, and particularly discloses a cross-linked chitosan hydrogel stomach filling agent as well as a preparation method and application thereof. The cross-linked chitosan hydrogel stomach filling agent comprises the following components in parts by weight: 10-40 parts of chitosan and 5-20 parts of adipic acid, the deacetylation degree of the chitosan is 60%-90%, and the relative molecular weight of the chitosan is 50-200kDa. The preparation method comprises the following steps: carrying out amidation reaction on amino groups on chitosan and carboxyl groups on adipic acid, and carrying out esterification condensation on hydroxyl groups on chitosan and carboxyl groups on adipic acid to form chemical cross-linking sites so as to prepare the polycationic hydrogel. After being taken as water, the stomach filler rapidly expands after absorbing liquid in a stomach acidic environment, has high swelling and occupies stomach space, and can provide obvious satiety, assist a user in controlling diet and reduce pain caused by diet control after being taken in a small amount.

Description

technical field [0001] The invention relates to the field of medical auxiliary technology, in particular to a cross-linked chitosan hydrogel gastric filling agent and its preparation method and application. Background technique [0002] Obesity and overweight have become a common global health problem in recent years and have attracted widespread attention from all walks of life. Exercise weight loss combined with diet control is recognized as the safest and most effective way to lose weight. The key is exercise, but it must also be combined with scientific diet control. While paying attention to controlling calorie intake, it must ensure that the normal nutritional needs of the human body are met. [0003] Gastric filler is an emerging material used to assist diet control, prevent and treat obesity, and manage weight. Its working principle is to allow the gastric filler to expand and occupy in the human gastrointestinal Stomach capacity provides a feeling of fullness. As ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K9/06A61P3/04A61K31/194
CPCA61K31/722A61K31/194A61K9/06A61P3/04A61K2300/00
Inventor 吴良平
Owner 北京华量引擎网络科技有限公司
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