Salvia miltiorrhiza potion compound extract with effect of preventing and treating pulmonary arterial hypertension and complications thereof and preparation method of salvia miltiorrhiza potion compound extract
A technology of pulmonary arterial hypertension and Danshen decoction, which is applied in the field of medicine, can solve problems that have not been reported in the literature, and achieve the effects of improving cardiopulmonary function, reducing pulmonary edema, and reducing remodeling phenomena
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Embodiment 1
[0035] The extraction and preparation of the compound extract of Danshenyin is carried out according to the weight ratio of Salvia miltiorrhiza: Amomum: Sandalwood = 10:1:1, and the preparation method is as follows:
[0036] ① After the medicinal materials are mixed in proportion, add 5 times the weight of water for the first time, soak for 2 hours and then transfer to the extraction tank;
[0037] ② Boil for 1 hour, and vacuum filter to pump the medicinal liquid to the concentration tank;
[0038] ③ Add water 4 times the weight of the remaining medicinal residues to the extraction tank, boil for 1 hour, vacuum filter the medicinal liquid to the concentration tank;
[0039] ④ Add water 3 times the weight of the remaining medicinal residues to the extraction tank, boil for 1 hour, vacuum filter the medicinal liquid to the concentration tank;
[0040] ⑤ Combine all the medicinal liquids, concentrate them, and pass through a 25-mesh sieve to obtain the medicinal liquids.
Embodiment 2
[0042] A preparation of Danshenyin compound granules for the prevention and treatment of pulmonary hypertension, the preparation method is as follows:
[0043] The medicinal liquid extracted according to the method of Example 1 was granulated in a fluidized bed according to the ratio of medicinal liquid:starch = 2:1 to 3:1, and the obtained granules were passed through a 16-mesh sieve, mixed, and packaged.
[0044] The prepared granules were dissolved in pure water at a concentration of 1g / 100mL, and the solution was analyzed and identified by HPLC. The chromatogram was as follows: figure 1 shown. According to the content determination, the main index components of Danshen drink were determined to be danshensu, protocatechualdehyde, rosmarinic acid and salvianolic acid B, and the mass ratio of the four compounds was 10:1:1.3:18.
Embodiment 3
[0045]Example 3 The pharmacodynamic effect of the Danshen decoction compound extract on the mouse model of hypoxic pulmonary hypertension
[0046] Fifteen male C57 mice, weighing about 20 g, were divided into three groups, 5 in each group: normal group, model group, and Danshenyin group. After 3 days of adaptive feeding, start to give 4.6g / kg of the compound extract of Danshenyin made in embodiment 2 by intragastric administration, and continue to administer for 7 days. On the 8th day, the animals of the model group and the Danshenyin administration group were put into low Oxygen chamber, fed in 10% oxygen environment for 14 days, while the Danshenyin group kept taking the compound extract of Danshenyin.
[0047] 1. The influence of Danshen decoction compound extraction on animal body weight changes:
[0048] In the above-mentioned process, the body weight of the animal is monitored, and the body weight change curve is drawn (attached figure 2 ). Under the normoxic state f...
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