Salvia miltiorrhiza potion compound extract with effect of preventing and treating pulmonary arterial hypertension and complications thereof and preparation method of salvia miltiorrhiza potion compound extract

A technology of pulmonary arterial hypertension and Danshen decoction, which is applied in the field of medicine, can solve problems that have not been reported in the literature, and achieve the effects of improving cardiopulmonary function, reducing pulmonary edema, and reducing remodeling phenomena

Pending Publication Date: 2022-04-22
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the analysis of its function characteristics, we speculate that it has a preventive or therapeutic effect on pulmonary hypertension, but this effect has not been reported in the literature so far

Method used

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  • Salvia miltiorrhiza potion compound extract with effect of preventing and treating pulmonary arterial hypertension and complications thereof and preparation method of salvia miltiorrhiza potion compound extract
  • Salvia miltiorrhiza potion compound extract with effect of preventing and treating pulmonary arterial hypertension and complications thereof and preparation method of salvia miltiorrhiza potion compound extract
  • Salvia miltiorrhiza potion compound extract with effect of preventing and treating pulmonary arterial hypertension and complications thereof and preparation method of salvia miltiorrhiza potion compound extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The extraction and preparation of the compound extract of Danshenyin is carried out according to the weight ratio of Salvia miltiorrhiza: Amomum: Sandalwood = 10:1:1, and the preparation method is as follows:

[0036] ① After the medicinal materials are mixed in proportion, add 5 times the weight of water for the first time, soak for 2 hours and then transfer to the extraction tank;

[0037] ② Boil for 1 hour, and vacuum filter to pump the medicinal liquid to the concentration tank;

[0038] ③ Add water 4 times the weight of the remaining medicinal residues to the extraction tank, boil for 1 hour, vacuum filter the medicinal liquid to the concentration tank;

[0039] ④ Add water 3 times the weight of the remaining medicinal residues to the extraction tank, boil for 1 hour, vacuum filter the medicinal liquid to the concentration tank;

[0040] ⑤ Combine all the medicinal liquids, concentrate them, and pass through a 25-mesh sieve to obtain the medicinal liquids.

Embodiment 2

[0042] A preparation of Danshenyin compound granules for the prevention and treatment of pulmonary hypertension, the preparation method is as follows:

[0043] The medicinal liquid extracted according to the method of Example 1 was granulated in a fluidized bed according to the ratio of medicinal liquid:starch = 2:1 to 3:1, and the obtained granules were passed through a 16-mesh sieve, mixed, and packaged.

[0044] The prepared granules were dissolved in pure water at a concentration of 1g / 100mL, and the solution was analyzed and identified by HPLC. The chromatogram was as follows: figure 1 shown. According to the content determination, the main index components of Danshen drink were determined to be danshensu, protocatechualdehyde, rosmarinic acid and salvianolic acid B, and the mass ratio of the four compounds was 10:1:1.3:18.

Embodiment 3

[0045]Example 3 The pharmacodynamic effect of the Danshen decoction compound extract on the mouse model of hypoxic pulmonary hypertension

[0046] Fifteen male C57 mice, weighing about 20 g, were divided into three groups, 5 in each group: normal group, model group, and Danshenyin group. After 3 days of adaptive feeding, start to give 4.6g / kg of the compound extract of Danshenyin made in embodiment 2 by intragastric administration, and continue to administer for 7 days. On the 8th day, the animals of the model group and the Danshenyin administration group were put into low Oxygen chamber, fed in 10% oxygen environment for 14 days, while the Danshenyin group kept taking the compound extract of Danshenyin.

[0047] 1. The influence of Danshen decoction compound extraction on animal body weight changes:

[0048] In the above-mentioned process, the body weight of the animal is monitored, and the body weight change curve is drawn (attached figure 2 ). Under the normoxic state f...

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Abstract

The invention relates to the technical field of medicines, and relates to application of a salvia miltiorrhiza beverage compound extract in treating pulmonary arterial hypertension and complications thereof. The invention particularly relates to application of the salvia miltiorrhiza beverage compound extract in preparation of medicines for preventing, relieving and / or treating pulmonary arterial hypertension and complications thereof. The salvia miltiorrhiza decoction compound extract has the effects of increasing the weight of animals with pulmonary arterial hypertension, improving the cardio-pulmonary function, reducing the pulmonary arterial pressure, inhibiting hypertrophy of right ventricular wall, relieving lung edema and the like, and plays a remarkable pharmacological role in preventing and treating the pulmonary arterial hypertension and complications of the pulmonary arterial hypertension. The effective extract of the salvia miltiorrhiza decoction may be an ideal medicine for preventing and treating pulmonary arterial hypertension and complications thereof, and can be used for preparing products for preventing, relieving and / or treating pulmonary arterial hypertension and complications thereof, chronic obstructive emphysema, chronic pulmonary heart disease, altitude sickness, hypoxia injury, right heart failure and immune function impairment.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a compound extract of Danshenyin in the preparation of medicines for preventing, alleviating and / or treating pulmonary hypertension and its complications. Background technique [0002] Pulmonary hypertension is a disease characterized by a progressive increase in pulmonary artery vascular pressure, and its clinical diagnostic criteria is a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg measured by right heart catheterization in a resting state. The incidence of pulmonary arterial hypertension has been on the rise in recent years. It is a disease with a high disability and death rate. Pulmonary arterial pressure, and the existing treatment drugs can not fully meet the clinical needs, pulmonary hypertension has a poor prognosis, and the 5-year survival rate is extremely low, it is a very serious disease involving the cardiovascular system and respiratory system...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P11/00A61P9/12A61P9/00A61P9/04
CPCA61K36/537A61K36/9064A61K36/185A61P11/00A61P9/12A61P9/00A61P9/04A61K2236/331A61K2236/39A61K2300/00
Inventor 杜冠华方莲花袁天翊孔令雷陈迪孙姝婵王冉冉马国栋
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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