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Preparation method of flunixin meglumine injection

A technology of flunixin meglumine and injection, which is applied in the field of preparation of flunixin meglumine injection, can solve problems such as research on the properties and content of injection, achieve excellent solubility, stable color, and solve poor solubility and easy discoloration effect

Active Publication Date: 2022-04-29
江西益昕葆生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent considers the problem of flocs produced after long-term storage caused by the solubility of flunixin meglumine in the injection, but does not study other properties and content of the injection after long-term storage

Method used

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  • Preparation method of flunixin meglumine injection
  • Preparation method of flunixin meglumine injection
  • Preparation method of flunixin meglumine injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of preparation of stable flunixin meglumine injection (preparation 1000mL):

[0033] 1) Dissolve 83.2 g of flunixin meglumine in 500 mL of water for injection for dissolving to obtain liquid A;

[0034] 2) Add 200mL of α-pyrrolidone to liquid A, stir well to obtain liquid B;

[0035] 3) Add 1g of Diaoba block and 0.2g of EDTA-2Na to liquid B to obtain liquid C;

[0036] 4) Add 50 g of methylcyclodextrin (stabilizer) to liquid C, and stir at 65°C for 20 minutes to dissolve, add nearly 1000 mL of water for injection for constant volume into the liquid mixing tank to obtain liquid D;

[0037]5) After cooling down to room temperature, add about 2.3mL of diethanolamine to liquid D, adjust the pH to 8.4 and continue to add water for constant volume injection to dilute to 1000ml to obtain a semi-finished product. After passing the quality inspection, add 3g of activated carbon and absorb for 15min. After filtering through a 0.22 μm metal titanium rod filter, subpackag...

Embodiment 2

[0051] A kind of preparation of stable flunixin meglumine injection (preparation 1000mL):

[0052] 1) Dissolve 83.2 g of flunixin meglumine in 400 mL of water for injection for dissolving to obtain liquid A;

[0053] 2) Add 400mL glycerin formal to A liquid, stir evenly to obtain B liquid;

[0054] 3) Add 1g of Diaoba block and 0.2g of EDTA-2Na to liquid B to obtain liquid C;

[0055] 4) Add 40 g of hydroxypropyl cyclodextrin (stabilizer) to liquid C, and stir at 65°C for 20 minutes to dissolve, add nearly 1000 mL of water for injection to the liquid preparation tank to obtain liquid D;

[0056] 5) After cooling down to room temperature, add about 2.2 mL of diethanolamine to liquid D, adjust the pH to 8.4 and continue to add constant volume water for injection to volume to 1000 ml to obtain a semi-finished product. After passing the quality inspection, add 3 g of activated carbon and absorb for 15 min. After filtering through a 0.22 μm metal titanium rod filter, subpackaging...

Embodiment 3

[0065] A kind of preparation of stable flunixin meglumine injection (preparation 1000mL):

[0066] 1) Dissolve 83.2 g of flunixin meglumine in 600 mL of water for injection for dissolving to obtain liquid A;

[0067] 2) Add 100mL of α-pyrrolidone to liquid A, stir well to obtain liquid B;

[0068] 3) Add 1g of Diaoba block and 0.2g of EDTA-2Na to liquid B to obtain liquid C;

[0069] 4) Add 30 g of ethyl cyclodextrin (stabilizer) to liquid C, and stir at 65°C for 20 minutes to dissolve, add nearly 1000 mL of water for injection for constant volume into the liquid mixing tank to obtain liquid D;

[0070] 5) After cooling down to 15°C, add about 2.4mL of triethanolamine to liquid D, adjust the pH to 8.4 and continue to add water for constant volume injection to make up to 1000ml to obtain a semi-finished product. After passing the quality inspection, add 3g of activated carbon and absorb for 15min , filtered through a 0.22 μm metal titanium rod filter, filled with nitrogen, su...

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Abstract

The invention relates to a veterinary drug injection, in particular to a preparation method of a flunixin meglumine injection, which comprises the following steps: dissolving flunixin meglumine in water for injection, adding an organic solvent and uniformly stirring, then adding sodium formaldehyde sulfoxylate and EDTA-2Na, stirring and dissolving, then adding a stabilizer and heating and stirring for dissolving, and finally adding a stabilizer and uniformly stirring to obtain the flunixin meglumine injection. Cooling, adding an acid-base regulator, and complementing the water for injection; and adding activated carbon into the obtained mixed solution, standing, filtering through a filter, filling nitrogen, subpackaging and sterilizing to obtain the flunixin meglumine injection. Compared with the prior art, the flunixin meglumine injection has the advantages that the nicotinamide or cyclodextrin stabilizer, the mixed solvent and the acid-base regulator are adopted, the dissolving property is more excellent, the effects of a cosolvent and the stabilizer are played at the same time, and the problems that flunixin meglumine medicine is poor in solubility and prone to discoloration are effectively solved.

Description

technical field [0001] The invention relates to a veterinary drug injection, in particular to a preparation method of flunixin meglumine injection. Background technique [0002] Flunixin Meglumine Injection is a new veterinary drug with antipyretic, analgesic and anti-inflammatory functions newly launched in recent years. Syndrome adjuvant therapy, etc. Because of its strong analgesic effect, no addiction, neither antagonism with naloxone, nor cross-resistance with codeine, nor dependence, and flunixin meglumine injection The simultaneous use of flunixin meglumine injection and antibacterial drugs can achieve the effect of "antibacterial and anti-inflammatory", so flunixin meglumine injection has been gradually popularized and applied in veterinary clinics. [0003] In the process of flunixin meglumine injection being used to treat diseases, the existing commercially available flunixin meglumine injection is prone to problems such as discoloration, stratification, and unst...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/44A61K47/18A61K47/22A61K47/40A61P29/00
CPCA61K9/08A61K9/0019A61K47/183A61K31/44A61K47/22A61K47/40A61P29/00Y02A50/30Y02A40/70
Inventor 李远森梁世仁覃智斌胡鹏飞蔡冬吴有林
Owner 江西益昕葆生物科技有限公司
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