Gas and liquid path system for automatic synthesis of nucleic acid and synthesis system

A technology of automatic synthesis and liquid circuit system, applied in the fields of organic chemistry, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low degree of automation, high operation error rate, high cost, and reduce labor costs and operation errors. efficiency, improve production efficiency

Pending Publication Date: 2022-06-03
北京擎科生物科技股份有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

The degree of automation of these processes is relatively low, the operation error rate is high, and the cost is high

Method used

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  • Gas and liquid path system for automatic synthesis of nucleic acid and synthesis system
  • Gas and liquid path system for automatic synthesis of nucleic acid and synthesis system
  • Gas and liquid path system for automatic synthesis of nucleic acid and synthesis system

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Embodiment Construction

[0049] In order to make the above and other features and advantages of the present invention more apparent, the present invention is further described below with reference to the accompanying drawings. It should be understood that the specific embodiments given herein are for the purpose of explaining to those skilled in the art, and are merely illustrative and not restrictive.

[0050] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", " Back, Left, Right, Vertical, Horizontal, Top, Bottom, Inner, Outer, Clockwise, Counterclockwise, Axial , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or imp...

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Abstract

The invention provides a gas and liquid path system for automatic synthesis of nucleic acid and a synthesis system, and belongs to the technical field of biology. The gas and liquid path system comprises a main pipeline, a first pipeline and a second pipeline, wherein the first pipeline and the second pipeline are arranged at one end of the main pipeline in parallel; the downstream of the first pipeline is provided with a reagent conveying module, the downstream of the reagent conveying module is provided with a plurality of nucleic acid automatic synthesis devices, and the nucleic acid automatic synthesis devices are communicated with waste liquid recovery modules; a gas path supply module is arranged at the downstream of the second pipeline and comprises a gas supply unit and a blowing and pressing unit which are arranged in parallel and can be communicated with the automatic nucleic acid synthesis equipment. The gas and liquid path system for reagent adding, cleaning and waste liquid recycling is provided in the automatic nucleic acid synthesis process, important guarantee is provided for building an automatic nucleic acid synthesis production line, and the gas and liquid path system has important practical significance.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a gas and liquid circuit system and a synthesis system for automatic nucleic acid synthesis. Background technique [0002] At present, synthetic DNA is the only known way of directional modification of gene sequences, and it is widely used in many fields such as protein modification and life science, such as nucleic acid drugs, enzyme engineering, gene detection, gene therapy, etc. [0003] In the commercial field of biosynthesis, during DNA synthesis, different reagents need to be injected into the synthesis column under the protection of an inert gas environment, and the reagents in the synthesis column need to be emptied after the reaction is completed. The synthesis process often involves operations such as reagent addition, cleaning solution cleaning, and inert gas cleaning. The process is complicated, and the waste liquid generated during the cleaning process needs to be dispos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H21/04C07H1/00C07H1/06
CPCC07H21/04C07H1/00C07H1/06
Inventor 马石金朱强杜军尤俊龙李彤孔祥
Owner 北京擎科生物科技股份有限公司
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