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Traditional Chinese medicine general flavone extract for treating cataract and composition, preparation method and medical application thereof

A technology of flavonoids and extracts, which can be applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem that the active ingredients of cataract are not found.

Active Publication Date: 2022-06-07
赣江新区艾泽生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the basis of screening more than 600 kinds of traditional Chinese medicines, we accidentally found that the extract of the wood butterfly can treat cataracts. Although it has been reported in the literature that the wood butterfly has a certain effect on the treatment of cataracts in the compound and alone, it has not been found that the wood butterfly extract can treat cataracts. Active ingredients for treating cataracts

Method used

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  • Traditional Chinese medicine general flavone extract for treating cataract and composition, preparation method and medical application thereof
  • Traditional Chinese medicine general flavone extract for treating cataract and composition, preparation method and medical application thereof
  • Traditional Chinese medicine general flavone extract for treating cataract and composition, preparation method and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: the preparation method of Chinese medicinal wood butterfly total flavonoid extract

[0054] Take traditional Chinese medicine wood butterfly, add 10 times the amount of 40% ethanol, soak at room temperature for 2 hours, then heat to 80 ~ 100 ° C for reflux extraction for 2 hours, separate the first extract, and then add 8 times the amount of 50% ethanol, heat to 80 ~ 100 ℃ reflux extraction for 1.5 hours, and separate the second extract. The two extracts were combined, and the solid impurities in the extract were removed by filtration. The extracting solution is recovered with solvent and dried to obtain 40% ethanol extract of the wood butterfly. According to the following determination method, the content of total flavonoids was determined to be 30.5%, and the content of each monomer: baicalein (6.7%), baicalin (0.2%), styloside A (10.8%), styloside B (8.6%) , chrysin (3.7%), chrysin-7-O-glucuronide (0.5%).

[0055] A method for the determination of th...

Embodiment 2

[0061] Embodiment 2: the preparation method of Chinese medicinal wood butterfly total flavonoids extract

[0062] Basically the same as Example 1, the difference is that water is an extraction solvent, and the specific method is as follows:

[0063] Take the traditional Chinese medicine A. chinensis, add 8 times the amount of water, soak at room temperature for 2 hours, then decoct and extract for 2 hours, separate the first extract, add 4 times the amount of water, decoct and extract for 1.5 hours, and separate the second extract. The two extracts were combined, and the solid impurities in the extract were removed by filtration. The extract is recovered by solvent, and dried to obtain the water extract of Butterfly. According to the following measurement method, the total flavonoid content was determined to be 20.6%, and the content of each monomer (determination method was the same as that of Example 1): baicalein (3.4%), baicalin (0.1%), xyloside A (8.1%), Trichoside B (7...

Embodiment 3

[0064] Embodiment 3: the preparation method of Chinese medicinal wood butterfly total flavonoids extract

[0065] It is basically the same as Example 1, the difference is that 70% ethanol is the extraction solvent, and the specific method is as follows: take the traditional Chinese medicine A. After 2 hours, the first extraction solution was separated, and then 8 times the amount of 70% ethanol was heated to 80-100° C. for reflux extraction for 1.5 hours, and the second extraction solution was separated. The two extracts were combined, and the solid impurities in the extract were removed by filtration. The extracting solution is recovered with solvent and dried to obtain 70% ethanol extract of the wood butterfly. The content of total flavonoids was determined to be 43.9%, and the content of each monomer (determination method was the same as that of Example 1): baicalein (6.8%), baicalin (3.9%), xyloside A (12.1%), xyloside B ( 10.7%), chrysin (2.9%), chrysin-7-O-glucuronide ...

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Abstract

The invention discloses a traditional Chinese medicine general flavone extract for treating cataract and a composition, a preparation method and medical application of the traditional Chinese medicine general flavone extract, traditional Chinese medicine general flavone is oroxylum indicum general flavone, and the invention further provides a quality control method of the oroxylum indicum general flavone. The oroxylum indicum general flavone contains baicalein, baicalin, oroxylin A, oroxylin B, chrysin and chrysin-7-O-glucuronide, and the total content of the six flavonoid compounds is greater than 20%.

Description

technical field [0001] The invention specifically relates to and discloses a traditional Chinese medicine Fructus chinensis total flavonoid extract for treating cataract, its composition and their preparation method, and discloses the medicinal use of the Fructus chinensis total flavonoid extract for treating cataract and its quality control method. Background technique [0002] The traditional Chinese medicine wood butterfly is the dried and mature seeds of Oroxylum indicum (Linn.) Kurz. It is one of the commonly used medicines in Chinese traditional medicine. It is commonly used for cough due to lung heat, throat paralysis, hoarseness, and pain in the liver and stomach. It is also used for the treatment of whooping cough and dry bronchitis. Its chemical composition mainly includes 4 categories of chemical components: flavonoids, 1(2H)-naphthone (1-3) and its dimers (4), anthraquinones such as aloe-emodin (5), pteranes (6) and phenylpyrone compounds (7). [0003] [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P27/12A61K31/352A61K31/122A61K31/015A61K31/357A61K31/351G01N30/02G01N30/06G01N30/32G01N30/34G01N30/54A61K131/00
CPCA61K36/185A61P27/12A61K31/352A61K31/122A61K31/015A61K31/357A61K31/351G01N30/02G01N30/06G01N30/34G01N30/32G01N30/54G01N2030/324
Inventor 王金辉李春莉谢平黄健李国玉杨璐于思琳张珂孙义凡孙仁宽王雁丽
Owner 赣江新区艾泽生物医药科技有限公司
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