Application of artemisinin and derivatives thereof in preparation of ChAT activity enhancer

An activity enhancer, artemisinin technology, applied in the field of medicine, can solve the problem of enhancing the activity of choline acetyltransferase, etc., to achieve the effects of reducing apoptosis, improving plasticity, and increasing activity

Pending Publication Date: 2022-06-28
UNIVERSITY OF MACAU +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0011] The previous studies of the inventors showed (CN109364064A, CN103948585A, CN112107576A) that artemisinin has the ability to prevent and treat stroke, prevent and treat neurological diseases, protect nerve cells, and promote learning and memory. The role of choline acetyltransferase activity

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  • Application of artemisinin and derivatives thereof in preparation of ChAT activity enhancer
  • Application of artemisinin and derivatives thereof in preparation of ChAT activity enhancer
  • Application of artemisinin and derivatives thereof in preparation of ChAT activity enhancer

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Embodiment Construction

[0056] The technical scheme of the present invention is further described below in conjunction with experiments.

[0057] The cells are characteristic of cholinergic neurons, express cholinergic-related genes, and can be used as an in vitro model of hippocampal cholinergic neurons. In this experiment, the inventors used the HT22 neuron in vitro model to determine the effect of artemisinin on cholinergic neurons.

[0058] Scopolamine, an acetylcholine muscarinic receptor blocker, is a commonly used modeling agent to induce cognitive impairment in animals. Intracerebroventricular or intraperitoneal injection of a certain dose of scopolamine (2 mg / kg) can cause abnormal cholinergic system and memory impairment. The inventor's research will provide an experimental basis for the preparation of clinical drugs for cognitive disorders. In addition, the inventor's study showed that low-dose artemisinin and its derivatives significantly improved cognitive impairment in senile dementia...

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Abstract

The invention discloses new application of artemisinin and derivatives thereof. The inventor finds that the artemisinin and the artemisinin derivatives significantly improve the activity of choline acetyltransferase in HT22 hippocampal neuronal cells and primary culture neurons, improve the plasticity of cholinergic neuronal synapses, and reduce the apoptosis of cholinergic neuronal cells, so that the function of a cholinergic nervous system is improved. In an animal model, the artemisinin and the derivatives thereof are also found to be capable of improving the activity of choline acetyltransferase and improving learning and memory. In addition, the artemisinin medicine also regulates/improves the activity of choline acetyltransferase of various cell tissues of animals of various ages, which indicates that the artemisinin medicine also can be used for treating other cholinergic insufficiency (abnormality) related diseases. Comprising but not limited to prevention and treatment of aging, postoperative cognitive impairment, dementia, schizophrenia, Huntington's disease, autism, myasthenia gravis, hyperactivity, respiratory distress syndrome and immune dysfunction of the organism.

Description

technical field [0001] The invention relates to the field of medicine, in particular to new applications of existing compounds, in particular to the application of artemisinin in the preparation of choline acetyltransferase activity enhancers. Background technique [0002] Choline is a component of all biofilms and the precursor of acetylcholine in cholinergic neurons, mainly promoting brain development and improving memory ability, ensuring information transmission, regulating cell apoptosis, forming biofilms, promoting fat metabolism, reducing Serum cholesterol, and promote functions such as transmethylation metabolism in the body. Traditional studies have believed that acetylcholine acts as a broad-spectrum neuromodulator in the brain and plays a homogenizing role in multiple brain regions. However, with the promotion of neural circuit research in recent years, the correlation between the neural circuits involved in acetylcholinergic neurons and learning, memory, attenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P25/00A61P25/02A61P39/06A61P25/28A61P25/18A61P25/14A61P37/02A61P21/04
CPCA61K31/366A61P25/00A61P25/02A61P39/06A61P25/28A61P25/18A61P25/14A61P37/02A61P21/04
Inventor 郑文华赵霞
Owner UNIVERSITY OF MACAU
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