Application of artemisinin and derivatives thereof in preparation of ChAT activity enhancer
An activity enhancer, artemisinin technology, applied in the field of medicine, can solve the problem of enhancing the activity of choline acetyltransferase, etc., to achieve the effects of reducing apoptosis, improving plasticity, and increasing activity
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[0056] The technical scheme of the present invention is further described below in conjunction with experiments.
[0057] The cells are characteristic of cholinergic neurons, express cholinergic-related genes, and can be used as an in vitro model of hippocampal cholinergic neurons. In this experiment, the inventors used the HT22 neuron in vitro model to determine the effect of artemisinin on cholinergic neurons.
[0058] Scopolamine, an acetylcholine muscarinic receptor blocker, is a commonly used modeling agent to induce cognitive impairment in animals. Intracerebroventricular or intraperitoneal injection of a certain dose of scopolamine (2 mg / kg) can cause abnormal cholinergic system and memory impairment. The inventor's research will provide an experimental basis for the preparation of clinical drugs for cognitive disorders. In addition, the inventor's study showed that low-dose artemisinin and its derivatives significantly improved cognitive impairment in senile dementia...
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