6 results about "Cholinergic Nerves" patented technology

The present invention discloses the use of Xinshubao tablets in preparing a drug for preventing and / or treating senile dementia. The present invention uses an AD animal model experiment constructed with scopolamine to determine that Xinshubao tablets improve the spatial learning and memory function of senile dementia mice by improving cortical and hippocampal tissue pathological damage, hippocampal neuron ultrastructure damage, and the cholinergic nervous system in the brain, and improving the neurotrophic state and synaptic function in the brain. The application of Xinshubao tablets in preventing and treating senile dementia has broad application prospects.

The present invention provides the use of an Iris fruit extract in preparing a product for preventing and / or treating nerve cell damage. The present invention establishes an AD model, and after treatment with the Iris fruit extract, the activities of SOD and GSH can be significantly increased, and the increase in MDA levels can be inhibited, and the AchE content can also be inhibited. This indicates that the Iris fruit extract can effectively improve the oxidative stress response in the pathological process of AD and improve the cholinergic nerve damage of AD.

The invention provides application of plant lactobacillus LZU-LJY-1Q1 in preparation of a product for improving memory ability damage, and belongs to the technical field of microorganisms. The invention finds that the plant lactobacillus LZU-LJY-1Q1 can achieve the effect of improving memory ability damage by improving neuron damage, resisting inflammation, improving oxidative stress and balancing brain cholinergic nervous system activity, and meanwhile, the plant lactobacillus LZU-LJY-1Q1 can be planted in human intestinal tracts and reproductive systems, so that host microecological balance is improved, beneficial effects on the intestinal tracts are achieved, and the effect of improving memory ability damage is achieved. And the effect of preventing memory impairment is achieved by reducing intestinal inflammatory response and adjusting the intestinal brain axis.

The present invention discloses a method for quantitatively detecting cholinergic nerves in sweat glands of neuronal intranuclear inclusion disease; belonging to the field of biological science and technology, the operation steps are as follows: skin biopsy; immunohistochemical staining; slide scanning; calculating the density of cholinergic nerve fibers. The method described in the present invention is a simple and easy method for quantitatively evaluating cholinergic nerve fibers in neuronal intranuclear inclusion disease; skin biopsies are performed on control recipients with neuronal intranuclear inclusion disease and without neurological diseases. After sectioning, immunofluorescence staining is performed using VIP antibody, and Image J software is used to quantitatively calculate the density of cholinergic nerve fibers labeled with VIP antibody in the dermal sweat glands, analyze whether there are differences in the two groups of recipients, and evaluate cholinergic nerve injury and severity; the present invention provides a new way for accurately evaluating the autonomic nerve injury and severity of neuronal intranuclear inclusion disease.

The invention provides a nerve soothing and brain strengthening and Alzheimer's disease intervention device and method based on multi-frequency resonance and head acupuncture point synergistic stimulation, the device comprises a helmet, an electromagnetic resonance generator, a miniature electromagnetic coil, a biocompatible electrode and a biological signal feedback unit, a heat dissipation assembly is arranged on the surface of the helmet, the heat dissipation assembly comprises a shell, and the shell is arranged on the surface of the helmet. A fixing assembly is arranged on the surface of the helmet, the fixing assembly comprises a rotary knob, the helmet, an electromagnetic resonance generator, a micro electromagnetic coil, a biocompatible electrode and a biological signal feedback unit are arranged, electromagnetic field induction of intercellular ion channel resonance is achieved through sequential control, a cholinergic nerve pathway is regulated through acupoint electrical stimulation, and the brain function is achieved. The effect of enhancing blood brain barrier permeability through bimodal cooperation is achieved, heat reduction work can be conveniently conducted when a patient wears the helmet by arranging the heat dissipation assembly, and adjustment can be conducted according to the size of the head circumference of the patient by arranging the fixing assembly.

The application discloses a method for constructing a microwave radiation animal brain injury model based on a medial septum-hippocampus CA3 cholinergic nerve loop regulation, comprising the following steps: setting electromagnetic radiation conditions, and performing electromagnetic radiation treatment on test animals; comparing whether a cholinergic nerve loop between the medial septum and the hippocampus CA3 is activated before and after the electromagnetic radiation treatment; and if the cholinergic nerve loop is activated, constructing an electromagnetic radiation animal brain injury model by using the electromagnetic radiation conditions. The application can accurately construct the electromagnetic radiation animal brain injury model, and increases the possibility of elucidating the molecular mechanism of the electromagnetic radiation brain injury effect and the research and development of prevention and treatment drugs.