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33 results about "Cholinergic Nerves" patented technology
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A nerve that releases the neurotransmitter acetylcholine at its synapse. The cholinergic nerves include all the preganglionic sympathetic and preganglionic parasympathetic nerves, the postganglionic parasympathetic nerves, the somatic motor nerves to skeletal muscles, and some nerves to sweat glands and to certain blood vessels.
Penehyclidine quaternary ammonium salt and its derivative
The invention discloses an ethyl ether quaternary ammonium salt and derivant as Choline-proof compound and preparing method with the following structure, wherein R is C1-C6 paraffin or substituted phenyl C1-C6 paraffin, which is methyl, phenylmethyl, ethyl group, propyl or isopropyl at best; M is halogen, which is F, Cl, Br or I at best. The invention can treat peripheral cholinergic nerve from exciting.
Owner:刘丽娅
Compositions and methods for inhibiting eccrine perspiration in humans
InactiveUS20060210504A1Eliminating sweat odorSlow stepCosmetic preparationsToilet preparationsSide effectSweat gland
Non-pathological, physiologically normal sweating is inhibited through use of an a muscarinic anticholinergic amine that blocks parasympathetic stimuli from cholinergic nerve fibers to an innerved sweat gland. The anticholinergic agent is included in a form adapted to be topically applied to commonly sweaty areas of the body. Side effects are minimized by employing amines which are charged at physiological pH, thereby minimizing their ability to cross biological membranes. The most prefered anticholinergic agents are salts of quaternary amines (quaternary ammonium salts) which are always charged.
Owner:LUKACSKO ALISON B
Assessment of relative proportions of adrenergic and cholinergic nervous receptors with non-invasive tests
InactiveUS20140350432A1High impedanceEarly detectionSensorsNervous system evaluationCholinergic NervesSweat gland
A system and method for assessing relative proportions of cholinergic and adrenergic nervous receptors in a patient is disclosed. The system includes: an anode, a cathode, and passive electrode for placement on different regions of the patient body. The method generally includes: applying DC voltage pulses of varying voltage values to stress sweat glands of the patient, collecting data representing the current between the anode and the cathode and the potential of the anode, the cathode, and the passive electrode for each of the different DC voltage, and computing data representing the electrochemical skin conductance of the patient. The computed data representing the electromechanical skin conductance of the patient is reconciled with reference data from control patients having known relative proportions of cholinergic and adrenergic nervous receptors. Thus, the relative proportions of cholinergic and adrenergic nervous receptors in the patient can be determined.
Owner:IMPETO MEDICAL
Application of acteoside in preparing medicine for treating alzheimer disease
InactiveCN102755341AAdjustment levelInhibition formationOrganic active ingredientsNervous disorderNervous systemCholesterol
The invention relates to an application of acteoside in preparing a medicine for treating alzheimer disease. The acteoside is used for preventing the alzheimer disease by multi-target-point action. The acteoside is synthesized artificially or is obtained from plants. Verified by in vivo and vitro experiments, the acteoside has the advantages that the central cholinergic nervous system can be improved, the level of glutamic acid can be adjusted, the formation and deposition of beta amyloid protein (Abeta) can be inhibited, the action of neuroprotection is achieved, the hyperphosphorylation of tau protein is inhibited, the antioxidant action is achieved, the cerebral circulation is improved, and cholesterol can be reduced, so that the multi-target-point prevention and treatment of the alzheimer disease is realized.
Owner:闫明
Chinese medicinal formulation for preventing and treating senile dementia and production method thereof
InactiveCN102526316ATonify kidney and replenish essenceWith promoting blood circulation and removing stasisNervous disorderPlant ingredientsAmnesiaNervous system
The invention discloses a Chinese medicinal formulation for preventing and treating senile dementia and a production method thereof. The invention is characterized in that the Chinese medicinal formulation is made from the following Chinese medicinal raw materials in parts by weight: 3-15 of Arillus longan pulp, 3-15 of Polygonum multiflorum and 3-15 of mulberry. The Chinese medicinal formulation has the effects of tonifying the kidney-essence, promoting blood circulation, removing blood stasis, nourishing the heart, soothing the mind and regulating the activity of acetylcholinesterase in the brain cholinergic nerve system; and can be used for prevention and treatment of senile dementia, manifested by symptoms of amnesia, insomnia, hypomnesia and change of activity of brain acetylcholinesterase (AchE) with good efficacy.
Owner:张树球
Puerarin derivative and synthetic method and application thereof
ActiveCN103382203AIncrease fat solubilityImprove fat solubility andOrganic active ingredientsNervous disorderChemical synthesisSolubility
A puerarin derivative and a synthetic method and an application thereof belong to the field of cerebrovascular diseases. Selectivity of a vascular dementia therapeutic target is improved by decorating puerarin. The puerarin derivative is indicated through a formula (1) which is as follows. By means of a chemical synthetic method, products are applied to treatment of vascular dementia. Fat solubility and water solubility of the puerarin are improved, receptor selectivity of the puerarin is improved, osmotic pressures inside and outside brain cells are balanced, cellular swelling caused by inflammatory injury is improved, a pharmacologic action of the puerarin itself of improving microcirculation and cholinergic nerve system functions is highlighted, and learning and memory disorders caused by damage caused by ischemia reperfusion are avoided.
Owner:HARBIN UNIV OF COMMERCE
Monoterpenyl bishydroxycoumarin compound, pharmaceutical composition, preparation method of monoterpenyl bishydroxycoumarin compound, and application of monoterpenyl bishydroxycoumarin compound and pharmaceutical composition
ActiveCN111848565AEasily damagedInhibitory activityNervous disorderOrganic chemistry methodsDicoumarolNervous system
The invention relates to the field of natural pharmaceutical chemistry and specifically provides a monoterpenyl bishydroxycoumarin compound, a pharmaceutical composition, a preparation method of the monoterpenyl bishydroxycoumarin compound, and application of the monoterpenyl bishydroxycoumarin compound and the pharmaceutical composition. The monoterpenyl bishydroxycoumarin compound has a structure as shown in a formula (I) which is described in the specification. In the formula, R1 to R6 and X1 to X4 are as defined in the specification. The monoterpenyl bishydroxycoumarin compound provided bythe invention can protect nerve cells from damage by inhibiting the activity of acetylcholin esterase, and has anti-inflammatory and antioxidant effects. Therefore, the compound can be used for preparing medicines for preventing and treating nervous system degenerative diseases such as senile dementia (also called Alzheimer's disease), cholinergic neurodegenerative change, learning and memory ability decline and the like.
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
Application of icaritin to medicine for treating Alzheimer disease
The invention relates to an application of icaritin to a medicine for treating the Alzheimer disease. Icaritin is taken as a main raw herb, and a proper amount of auxiliary materials are added to prepare an oral preparation or an injection. By deep and detailed research of icaritin on aspects, such as a pharmacological action and an action mechanism, it is found that icaritin can obviously reduce Abeta aggregation and cholinergic nerve functional impairment, due to Abeta<25-35>, of a dementia rat model, and obviously improves the learning and memory dysfunction of the dementia rat model. Icaritin can reduce Abeta aggregation and improves the function of brain cholinergic nerve, produces a function of resisting Abeta<25-35> neurotoxicity, and obviously improves the learning and memory ability of the dementia rat model. According to the invention, by researching the effects of icaritin on the learning and memory ability, the cholinergic system, and an Abeta metabolic pathway of the dementia rat model, the pharmacological action mechanism of icaritin on treating the Alzheimer disease is illustrated, and pharmacological foundations on application of further developing icaritin are provided.
Owner:ZUNYI NO 1 PEOPLES HOSPITAL
Application of semen aesculi extract to preparation of medicine for preventing and treating senile dementia
InactiveCN107281203AOrganic active ingredientsSugar food ingredientsMixed dementiaCholinergic Nerves
The invention discloses application of a semen aesculi extract to preparation of a medicine and a health-care product for preventing and treating senile dementia, wherein the active component of the semen aesculi extract is beta-aescin. According to experiments, the traditional Chinese medicine semen aesculi extract can obviously improve dysmnesia of model animals and improve the learning capability, can effectively improve and adjust central cholinergic nerve as well as adjust free radical metabolism, and has exact curative effect on various kinds of senile dementia such as Alzheimer's disease, vascular dementia and mixed dementia.
Owner:南京惠宝生物医药有限公司
Application of fructus lycii extract to preparation of medicine for preventing and treating senile dementia
InactiveCN106138426AAvoid deficiencies of unclear active ingredientsImprove memory impairmentNervous disorderPlant ingredientsDiseaseDrugs preparations
The invention relates to a traditional Chinese medicinal material fructus lycii extract, a preparation method of medicine preparation of the traditional Chinese medicinal material fructus lycii extract, and application of the fructus lycii extract to preparation of a medicine and a health care product which can prevent and treat senile dementia. An experiment shows that the traditional Chinese medicinal material fructus lycii extract can obviously improve the dysmnesia of an animal pattern and enhance the learning ability, has various effects of effectively improving and adjusting the central cholinergic nerve, adjusting free-radical metabolism and the like, and has a definite treating effect on various senile dementia diseases such as Alzheimer's disease and vascular dementia.
Owner:NANJING HAIHENG MEDICINE SCI & TECH CO LTD
Method for producing cholinergic neural cells
InactiveUS20170266235A1Rapid productionHigh purityPeptide/protein ingredientsGenetic material ingredientsDiseaseProgenitor
The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
Owner:KOREA RES INST OF BIOSCI & BIOTECH
Radix linderae extract for treating diabetic bladder dysfunction disease and preparation method thereof
InactiveCN105796642AGood curative effectAdjust diastolic tensionPowder deliverySpray deliveryDiseaseCholinergic Nerves
The invention discloses a radix linderae extract for treating diabetic bladder dysfunction disease and a preparation method thereof. The radix linderae extract prepared by the preparation method has a perfect curative effect on bladder dysfunction disease and particularly diabetic bladder dysfunction disease and can be used for preparing a related medicine; and the medicine consists of the radix linderae extract and medically acceptable accessories, wherein 500-5,000mg of radix linderae extract is contained in daily dosage. The radix linderae extract and medicine thereof can regulate the diastolic and systolic tension of the bladder smooth muscle so as to regulate the bladder function; and the mechanism is related to a cholinergic nerve receptor (M receptor), a beta-adrenergic receptor (beta-AR) and a non-cholinergic non-adrenergic TRPV1 passage. Therefore, the radix linderae extract can be used for preventing and treating bladder dysfunction disease and has wide application prospects in preparing a medicine for preventing and / or treating diabetic bladder dysfunction disease.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
Application of artemisinin and derivatives thereof in preparation of ChAT activity enhancer
PendingCN114668758AHigh activityImprove plasticityOrganic active ingredientsNervous disorderHomocholineNervous system
The invention discloses new application of artemisinin and derivatives thereof. The inventor finds that the artemisinin and the artemisinin derivatives significantly improve the activity of choline acetyltransferase in HT22 hippocampal neuronal cells and primary culture neurons, improve the plasticity of cholinergic neuronal synapses, and reduce the apoptosis of cholinergic neuronal cells, so that the function of a cholinergic nervous system is improved. In an animal model, the artemisinin and the derivatives thereof are also found to be capable of improving the activity of choline acetyltransferase and improving learning and memory. In addition, the artemisinin medicine also regulates / improves the activity of choline acetyltransferase of various cell tissues of animals of various ages, which indicates that the artemisinin medicine also can be used for treating other cholinergic insufficiency (abnormality) related diseases. Comprising but not limited to prevention and treatment of aging, postoperative cognitive impairment, dementia, schizophrenia, Huntington's disease, autism, myasthenia gravis, hyperactivity, respiratory distress syndrome and immune dysfunction of the organism.
Owner:UNIVERSITY OF MACAU +1
Traditional Chinese medicine preparation used for preventing and treating aluminum-induced senile dementia
ActiveCN102847022AAccelerate the conversion and excretionProtective functionNervous disorderPlant ingredientsNervous systemTremella
The invention discloses a traditional Chinese medicine preparation used for preventing and treating aluminum-induced senile dementia (AD). The medicine preparation is characterized in that the traditional Chinese medicine preparation is prepared from the raw materials of, by weight: 5-15 parts of tuckahoe, 3-6 parts of licorice root, 1-3 parts of glabrous greenbrier rhizome, 5-15 parts of ma-yuen jobstears seed, 5-10 parts of white tremella, and 1-3 parts of mung bean seed-coat. The medicine preparation has the functions of heat clearing, detoxifying, spleen strengthening, dampness eliminating, liver protecting, kidney protecting, blood circulation activating, stasis removing, and the like. With the medicine preparation, excretion of excessively accumulated aluminum in AD patient brains can be promoted; excessive harmful superoxide anion radicals such as O2 can be removed; brain cholinergic nerve system choline acetyltransferase (ChAT) activity, acetylcholinesterase (AchE) activity, and acetylcholine neurotransmitter content can be regulated; and patient memory and cognitive ability can be recovered and enhanced. The traditional Chinese medicine preparation is suitable to be used by AD patients in preventing and treating.
Owner:广西百色清醒科技有限公司
Traditional Chinese medicine preparation for preventing and treating aluminum-induced Alzheimer's disease and its production method
ActiveCN102847022BAccelerate the conversion and excretionProtective functionNervous disorderPlant ingredientsDiseaseNervous system
Owner:广西百色清醒科技有限公司
Application of farnesyltransferase inhibitors in preparation of medicine for facilitated cholinergic nerve system
InactiveCN106667988AHigh activityHigh expressionOrganic active ingredientsNervous disorderIntraperitoneal routeCholinergic Nerves
The invention relates to an application of farnesyltransferase inhibitors (FTI) in preparation of a medicine for a facilitated cholinergic nerve system. The farnesyltransferase inhibitors have an obvious improvement effect on senile dementia, Alzheimer's disease cognitive disorder, vascular dementia and Parkinson's disease cognitive function decline. Specifically speaking, in aging mice, Alzheimer's disease model mice, dementia model mice suffering cerebral ischemia and Parkinson's disease cognitive function decline model mice, the FTI, after subjected to treatment in the ways such as oral cavity injection, intraperitoneal injection, intracerebroventricular injection or cell incubation, can all dose-dependently (1) increase the activity and expression of a nerve cell acetylcholine receptor alpha7nACh, (2) improve dementia behavior, and (3) recover the synaptic transmission effect and long-term potentiation induction of the hippocampal brain.
Owner:NANJING MEDICAL UNIV
Coumarin dimer compound, pharmaceutical composition, and preparation method and application of the coumarin dimer compound
ActiveCN111072683AEasily damagedHigh expressionNervous disorderOrganic chemistryNervous systemCholinergic Nerves
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
A kind of pharmaceutical composition for treating Alzheimer's disease
ActiveCN104606464BEasy to learnIncreased ACh contentNervous disorderLeech/worm material medical ingredientsCholinergic NervesGanoderma lucidum
The invention discloses a pharmaceutical composition for treating Alzheimer's disease, which is prepared from the following raw materials in parts by weight: 1-5 parts of Shouwu, 1-5 parts of Ganoderma lucidum, 1-2 parts of leech, 1 part of Anemarrhena ‑2 servings. The present invention combines traditional Chinese medicine theory with clinical features of Alzheimer's disease (AD) and pharmacological research methods to formulate prescriptions. Pharmacological research shows that the pharmaceutical composition of the present invention has multi-component, multi-target, Features of multiple pathways. The pharmaceutical composition of the present invention can significantly improve the learning and memory abilities of various AD rats and mouse models; it has obvious anti-inflammation to AD models; it can reduce free radical damage; it can improve energy metabolism disorders in the brain; it can obviously inhibit the hippocampus of AD rats Neuronal apoptosis rate, play a role in central cholinergic neuroprotection and anti-dementia.
Owner:南通大学技术转移中心有限公司
Coumarin dimer compound, pharmaceutical composition, preparation method and application thereof
The invention relates to the field of natural pharmaceutical chemistry, and particularly provides a coumarin dimer compound, a pharmaceutical composition and a preparation method and application of the coumarin dimer compound. The coumarin dimer compound has a structure shown as a formula I shown in the specification. The coumarin dimer compound can remarkably improve nerve cell damage of an A[beta]1-42 induced senile dementia model; moreover, can improve neurotrophic factor expression, has anti-inflammatory and antioxidant effects, and can be used for preventing and treating nervous system degenerative diseases such as vascular dementia, vascular cognitive impairment, senile dementia (also called Alzheimer's disease), cholinergic neurodegenerative change, learning and memory ability decline and the like.
Owner:CHINA RESOURCES SANJIU MEDICAL & PHARMA
Puerarin derivatives and their synthetic methods and applications
ActiveCN103382203BIncrease fat solubilityImprove fat solubility andOrganic active ingredientsNervous disorderSolubilityChemical synthesis
A puerarin derivative and a synthetic method and an application thereof belong to the field of cerebrovascular diseases. Selectivity of a vascular dementia therapeutic target is improved by decorating puerarin. The puerarin derivative is indicated through a formula (1) which is as follows. By means of a chemical synthetic method, products are applied to treatment of vascular dementia. Fat solubility and water solubility of the puerarin are improved, receptor selectivity of the puerarin is improved, osmotic pressures inside and outside brain cells are balanced, cellular swelling caused by inflammatory injury is improved, a pharmacologic action of the puerarin itself of improving microcirculation and cholinergic nerve system functions is highlighted, and learning and memory disorders caused by damage caused by ischemia reperfusion are avoided.
Owner:HARBIN UNIV OF COMMERCE
Drug for treating hypothyroidism
InactiveCN106074550AMake up for the shortcoming of neurocognitive function returning to normalGood treatment effectNervous disorderEndocrine system disorderSevere hypothyroidismJuvenile hypothyroidism
The invention provides a drug for treating hypothyroidism. The drug is suitable for being used by a hypothyroidism patient who is exactly diagnosed in clinic and then subjected to levothyroxine sodium treatment for three months, but has no significant neurocognitive impairment improvement effect, and the patient orally takes donepezil hydrochloride tablets with the dosage of 5 mg every day. The drug is donepezil hydrochloride, can enhance function exertion of cholinergic nerves, reversibly inhibit hydrolysis of acetylcholin esterase on acetylcholine, increase the concentration of acetylcholine in the brain and promote recovery of related damaged synaptic proteins such as munc-18 and syt-1 in the brain, is more beneficial for recovery of a neurocognitive function of the patient, overcomes the defect that neurocognitive impairment cannot be completely recovered through traditional levothyroxine sodium replacement treatment and achieves the purpose of better treating the hypothyroidism.
Owner:朱德发 +4
Application of bibenzyl compounds in the preparation of drugs for promoting gastrointestinal motility
ActiveCN110151740BPromote peristalsisPromote emptyingDigestive systemEther/acetal active ingredientsNervous systemAgonist drugs
Owner:ZUNYI MEDICAL UNIVERSITY
Preparation process and test method of mangosteen shell water decoction for inhibiting gastrointestinal motility
PendingCN114796298ASolve the problem of how to exert the antidiarrheal effectConducive to in-depth development and utilizationDigestive systemPlant ingredientsTraditional medicineCholinergic Nerves
The invention discloses a preparation process and a test method of a mangosteen shell water decoction for inhibiting gastrointestinal motility, comprising a preparation process of a mangosteen shell water decoction, a charcoal powder suspension and nutritional semisolid paste, and a test method of the influence of the applied mangosteen shell water decoction on cholinergic nerves and adrenergic nerves. The mangosteen shells are utilized, the problem that how the mangosteen shell water decoction plays an antidiarrheal role can be solved through discussion of the mangosteen shell water decoction on inhibiting the gastrointestinal motility mechanism, a reference basis is provided for developing a clinically safe and effective antidiarrheal, and due to the fact that the materials are convenient to take and rich in resource, the mangosteen shell water decoction has a very good application prospect. Meanwhile, the implementation of the invention is also beneficial to deep development and utilization of local characteristic Chinese herbal medicine resources.
Owner:广西卫生职业技术学院
IGF-1 to improve neural outcome
InactiveUSRE43982E1Reduce severityImprove concentrationNervous disorderPeptide/protein ingredientsInsulin-like growth factorDisease
A method of treating injuries to or diseases of the central nervous system that predominantly effects glia and / or non-cholinergic neuronal cells characterized in that it comprises the step of increasing the active concentration(s) of insulin-like growth factor 1 and / or analogues thereof in the central nervous system of the patient. The present invention also provides therapeutic compositions comprising insulin-like growth factor 1 and / or analogues thereof for administration to a patient at or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.
Owner:AUCKLAND UNISERVICES LTD +1
Traditional Chinese medicine for preventing and treating senile dementia and production method
InactiveCN111617151AMemory lossChange activityNervous disorderPlant ingredientsModern medicineNervous system
The invention discloses a traditional Chinese medicine for preventing and treating senile dementia and a production method, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine is prepared from radix salviae miltiorrhizae, arillus longan, radix polygoni multiflori (processed) and fructus mori according to the scientific configuration of the combination of thetheory of traditional Chinese medicine, the theory of modern medicine and experiments. The production method comprises the following steps: extracting the above medicines with water, carrying out alcohol precipitation and concentration, preparing powder and preparing oral liquid, granules, capsules and tablets by using modern pharmaceutical production processes. The traditional Chinese medicine has the pharmacological effects of tonifying the kidney and replenishing essence, invigorating blood circulation and removing blood stasis, tranquilizing mind by nourishing the heart, adjusting the activity of acetylcholinesterase and choline acetyl transferase in the cholinergic nervous system of the brain, eliminating oxygen free radicals, discharging aluminum and the like. The traditional Chinese medicine is used for preventing and treating amnesia, insomnia, hypomnesis, activity change of acetylcholinesterase (AchE) and choline acetyl transferase (chAT) of the brain, elimination of oxygen free radicals, discharging aluminum and the like caused by senile dementia.
Owner:凌霄雁 +4
Traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and production method of traditional Chinese medicine preparation
InactiveCN111888440ASleep betterEnhance memoryNervous disorderPlant ingredientsDiseaseLiver and kidney
The present invention relates to the technical field of traditional Chinese medicines and particularly to a traditional Chinese medicine preparation for preventing and treating Alzheimer's disease anda production method of the traditional Chinese medicine preparation. Effective ingredients of the traditional Chinese medicine preparation consist of the following traditional Chinese medicine raw materials in parts by weight: 1-2 parts of fructus alpiniae oxyphyllae, 3-6 parts of spine date seeds, 5-15 parts of coix seeds, 2-5 parts of longan aril, 1-2 parts of radix salviae miltiorrhizae, 5-15parts of poria cocos, 3-6 parts of mulberries, 1-2 parts of honeysuckle, 0.5-1 part of licorice and 5-10 parts of lily bulbs. The traditional Chinese medicine preparation is oral liquid, granules, capsules, tablets or other medicinal dosage form. The traditional Chinese medicine preparation is scientifically prepared according to combination of traditional Chinese medicine theory and modern medical experiments, has functions of nourishing the kidneys and filling essence, promoting blood circulation and removing stasis, nourishing the heart and calming nerves, removing toxins, strengthening thespleen and removing dampness, protecting the liver and kidneys, has pharmacological effects on regulating transferase activity of acetylcholinesterase and acetylcholine in a brain cholinergic nerve system, scavenging oxygen free radicals, excreting aluminum, etc., and can effectively prevent and treat Alzheimer's disease.
Owner:凌霄雁 +3
Preparation and application of effective parts of platycladi seeds
The invention relates to preparation and application of an effective parts of platycladi seeds. The invention is characterized in the application of the effective parts of the platycladi seeds to preparation of senile dementia preventing and treating medicines and health products, wherein the content of the effective part of the platycladi seed is not lower than 60%. Experimental research proves that the effective part of the platycladi seed can improve the memory disorder of a model animal and improve the learning and memory capability thereof; the effective part of the platycladi seed has the effects of reducing formation of senile plaques, effectively improving and regulating the central cholinergic nervous system, regulating metabolism of free radicals and the like; the effective part of the platycladi seed has an exact therapeutic effect on senile dementia, including Alzheimer's disease, vascular dementia, mixed dementia and the like.
Owner:南京惠宝生物医药有限公司
Use of benzhexol hydrochloride in withdrawal and treatment of opium poison
InactiveCN101396362ALess investmentLow costOrganic active ingredientsNervous disorderDrug withdrawal symptomsClinical trial
The invention relates to the application of paralest in the opium drug detoxification abstinence treatment and belongs to the technical field of addiction medicine application. According to the functional characteristics of paralest of selectively breaking the cholinergic nerve tract of striaturn, inhibiting the hyperfunction of acetylcholine, correspondingly improving the effect of brain dopamine, being good for keeping or recovering the balance of two transmitter systems of striaturn dopamine (DA) and acetylcholine (Ach) and causing no drug dependence after long time usage, the paralest is used for the treatments, such as opium drug detoxification (acute abstinence symptom), healing (protracted abstinence syndrome), etc. Experimentation on animals and clinical trial show that the invention not only develops the application range of traditional drugs, but also has the advantages of investment saving, the low cost of product, strong practicability, good effect, etc. The paralest can be widely applied to the opium drug abstinence treatment.
Owner:袁才尉
Pharmaceutical composition for treating alzheimer disease
ActiveCN104606464AEasy to learnIncreased ACh contentNervous disorderLeech/worm material medical ingredientsApoptosisStudy methods
The invention discloses a pharmaceutical composition for treating alzheimer disease. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 1-5 parts of processed radix polygoni multiflori preparata, 1-5 parts of ganoderma lucidum, 1-2 parts of leech and 1-2 parts of rhizoma anemarrhenae. A prescription is formed by combining the traditional theory of the traditional Chinese medicine with the medical clinical characteristics of the alzheimer disease (AD) and the pharmacology research method. A pharmacological study proves that the pharmaceutical composition has multi-component, multi-target point and multi-way action characteristics on treatment of the AD. The pharmaceutical composition disclosed by the invention is capable of obviously improving learning and memory capabilities of a plurality of mice or rat models of AD, has an obvious anti-inflammatory effect, and is capable of relieving free radical injuries, improving self-energy metabolic disturbance in the brain, obviously inhibiting the apoptosis rate of hippocampal neurons of the AD rats, and playing roles in protecting nerves and resisting dementia by a central cholinergic system.
Owner:南通大学技术转移中心有限公司
Ligand for Vesicular Acetylcholine Transporter
InactiveUS20090163461A1Improve versatilityBiocideGroup 4/14 element organic compoundsDiseaseRadioactive tracer
The present invention provides a novel compound represented by the formula (I):wherein R1 and R2 are as defined in the specification, or a salt thereof, which is useful as a reagent (radiotracer) for VAChT mapping and the like, and can be used for positron emission tomography (PET), and a production method of the compound. Moreover, the present invention provides a diagnostic reagent for diagnosing cholinergic neurodegenerative disorders (e.g., Alzheimer's disease, memory disorder, learning disorder, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgia, Parkinson's disease and the like) and the like, which contains the aforementioned compound.
Owner:KANAZAWA UNIV
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