Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dai medicine composition for preventing and/or treating reperfusion injury after myocardial ischemia

A technology for reperfusion injury and myocardial ischemia, which can be used in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc., and can solve the problems of high cost and many medicinal flavors.

Active Publication Date: 2022-07-08
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Li Ji et al. Research progress of traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury [J], Journal of Traditional Chinese Medicine, 2015, 43 (2) disclosed that Chinese medicine compound Zhigancao Decoction, Guizhi Gancao Decoction, Jiawei Shengmai Decoction, etc. have anti-myocardial The role of ischemia-reperfusion injury, but these traditional Chinese medicine prescriptions have many flavors and high costs. It is necessary to develop safer, more effective and economical traditional Chinese medicine prescriptions to relieve the pain of clinical MIRI patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dai medicine composition for preventing and/or treating reperfusion injury after myocardial ischemia
  • Dai medicine composition for preventing and/or treating reperfusion injury after myocardial ischemia
  • Dai medicine composition for preventing and/or treating reperfusion injury after myocardial ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, the preparation of the medicine of the present invention

[0032] Formula: 20g of turmeric, 30g of hematoxylin, 25g of centering vine.

[0033] Preparation:

[0034] 1) Preparation of turmeric extract: take the root of turmeric, pulverize, add 5-8 times the weight of hot water (100 ° C) to extract, the extract is concentrated into an extract, and the sample is loaded on a macroporous resin column (LX-T28 macroporous resin). , Xi'an Lanxiao Technology New Materials Co., Ltd.), eluted with 8-10 column volumes of 75% methanol, collected the eluate, concentrated under reduced pressure at 50 °C to a solution density of 1.10-1.15, and then loaded on a macroporous resin column, Elute with 5-6 column volumes of 60% methanol, collect the eluate, concentrate under reduced pressure at 50°C to a solution density of 1.10-1.15, and freeze-dried the concentrated solution to obtain 2g of turmeric extract;

[0035] 2) Preparation of hematoxylin extract: take the dried he...

Embodiment 2

[0038] Embodiment 2, the preparation of the medicine of the present invention

[0039] Formula: 18g turmeric, 25g hematoxylin, 25g centering rattan.

[0040] Preparation method: Preparation method: 1) Preparation of turmeric extract: take the root of turmeric, pulverize, add 5-8 times the weight of hot water (100 ° C) to extract, the extract is concentrated into an extract, and the sample is loaded on a macroporous resin column ( LX-T28 macroporous resin, Xi'an Lanxiao Technology New Materials Co., Ltd.), eluted with 8-10 column volumes of 75% methanol, collected the eluate, concentrated under reduced pressure at 50 °C to a solution density of 1.10-1.15, and then loaded On a macroporous resin column, eluting with 5-6 column volumes of 60% methanol, collecting the eluate, concentrating under reduced pressure at 50 °C to a solution density of 1.10-1.15, and lyophilizing the concentrated solution to obtain turmeric extract;

[0041] 2) Preparation of hematoxylin extract: take th...

Embodiment 3

[0044] Embodiment 3, the preparation of the medicine of the present invention

[0045] Formula: 24g turmeric, 30g hematoxylin, 30g centering rattan.

[0046] Preparation method: Preparation method: 1) Preparation of turmeric extract: take the root of turmeric, pulverize, add 5-8 times the weight of hot water (100 ° C) to extract, the extract is concentrated into an extract, and the sample is loaded on a macroporous resin column ( LX-T28 macroporous resin, Xi'an Lanxiao Technology New Materials Co., Ltd.), eluted with 8-10 column volumes of 75% methanol, collected the eluate, concentrated under reduced pressure at 50 °C to a solution density of 1.10-1.15, and then loaded On a macroporous resin column, eluting with 5-6 column volumes of 60% methanol, collecting the eluate, concentrating under reduced pressure at 50 °C to a solution density of 1.10-1.15, and lyophilizing the concentrated solution to obtain turmeric extract;

[0047] 2) Preparation of hematoxylin extract: take th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Dai medicine composition for preventing and / or treating reperfusion injury after myocardial ischemia. The Dai medicine composition is prepared from the following raw material medicines in parts by weight: 4-1 part of turmeric, 2-1 part of sappan wood and 2-1 part of mappianthus iodoratum. The composition can relieve H9C2 myocardial cell injury caused by hypoxia / reoxygenation, has the activity of resisting myocardial ischemia-reperfusion injury, and particularly has the best activity of resisting myocardial ischemia-reperfusion injury when the turmeric, the sappan wood and the mappianthus iodoratum extract are mixed according to the proportion of 2: 1: 1. Compared with a traditional Chinese medicine compound reported at present, the traditional Chinese medicine compound has the advantages that the pain of clinical MIRI patients can be relieved by using fewer medicines, and the traditional Chinese medicine compound has clinical popularization and application values.

Description

technical field [0001] The present invention specifically relates to a Dai medicine composition for preventing and / or treating myocardial ischemia-reperfusion injury. Background technique [0002] Myocardial ischemia-reperfusion injury (MIRI) means that after partial or complete acute occlusion of the coronary artery, when the ischemic myocardium is restored to normal perfusion after a certain period of time, its tissue damage is progressively aggravated. process. A series of damaging changes in myocardial ultrastructure, energy metabolism, cardiac function and electrophysiology caused by ischemia are more prominent after recanalization of blood vessels, and even severe arrhythmia can lead to sudden death. [0003] The prevention and treatment of myocardial ischemia-reperfusion injury include: scavenging free radicals, "ischemic postconditioning" treatment, inhibiting the exchange between Na+F / H+, Na+ / Ca2+ ions, applying adenosine receptor agonists, magnesium agents, statin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10
CPCA61K36/9066A61K36/48A61K36/185A61P9/10A61K2236/331A61K2236/55A61K2236/333A61K2236/39A61K2300/00Y02A50/30
Inventor 陈佳张莹莹李媛罗淑杰李文春郑国伟
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com