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Compound and Dai medicine composition for resisting myocardial ischemia-reperfusion injury and application of compound and Dai medicine composition

A reperfusion injury, anti-myocardial ischemia technology, applied in the direction of drug combination, separation/purification of carbonyl compounds, cardiovascular system diseases, etc., can solve myocardial ischemia-reperfusion injury, there is no prevention and treatment method, and aggravate irreversible heart failure And other issues

Active Publication Date: 2022-07-12
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Ischemic heart disease is currently the disease with the highest morbidity and mortality in the world. The clinical treatment plan is to restore the blood perfusion of coronary arteries in time, but myocardial ischemia-reperfusion injury (Myocardial Ischemia-reperfusion Injury, Myocardial Ischemia-reperfusion Injury, MIRI), that is, the structural and functional damage of myocardial cells caused by ischemia is not improved by restoring blood supply, but aggravated or even irreversible heart failure
MIRI has become an important reason for the high incidence of postoperative mortality in ischemic heart disease, and there is no ideal prevention and treatment method
So far, there is no report on non-curcuminoid components in turmeric against myocardial ischemia-reperfusion injury

Method used

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  • Compound and Dai medicine composition for resisting myocardial ischemia-reperfusion injury and application of compound and Dai medicine composition
  • Compound and Dai medicine composition for resisting myocardial ischemia-reperfusion injury and application of compound and Dai medicine composition
  • Compound and Dai medicine composition for resisting myocardial ischemia-reperfusion injury and application of compound and Dai medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, the preparation of alkane type sesquiterpenoid component Bisadinrone A of the present invention

[0049]1) Take the root of turmeric, pulverize it, add 5-8 times weight of hot water (100°C) for reflux extraction, and concentrate the extract under reduced pressure at 50°C into an extract, which is loaded on a macroporous resin column (LX-T28 macroporous resin) , eluted with 6-8 column volumes of 45% methanol, collected the eluent, concentrated under reduced pressure at 50°C to a relative density of 1.10-1.15, and then loaded on a macroporous resin column, eluted with 3-5 column volumes of 80% methanol , collect the eluate, and concentrate under reduced pressure at 50°C to a relative density of 1.10-1.15;

[0050] 2) Take the concentrated solution obtained in step 1), separate it by preparative high performance liquid chromatography, collect the effluent corresponding to the chromatographic peak with the largest response value, and then load it on a Sephadex...

Embodiment 2

[0054] Embodiment 2, the preparation of alkane type sesquiterpenoid component Bisacurone of the present invention

[0055] 1) Take the root of turmeric, pulverize it, add 5-8 times weight of hot water (100°C) for reflux extraction, and concentrate the extract under reduced pressure at 50°C into an extract, which is loaded on a macroporous resin column (LX-T28 macroporous resin) , eluted with 6-8 column volumes of 45% methanol, collected the eluent, concentrated the solution under reduced pressure at 50°C with a density of 1.15-1.20, and then loaded the sample on a macroporous resin column, eluted with 3-5 column volumes of 20% methanol, Collect the eluate, and concentrate the solution under reduced pressure at 50°C to a density of 1.15-1.20;

[0056] 2) Take the concentrated solution obtained in step 1), separate it by preparative high performance liquid chromatography, collect the effluent corresponding to the chromatographic peak with the largest response value, and then loa...

Embodiment 3

[0060] Example 3 Preparation of the composition of the present invention

[0061] 1) Preparation of hematoxylin extract

[0062] Take the dried hematoxylinum heartwood, pulverize it, add 8 times the weight of 80% edible ethanol, and soak for 48 hours. Ultrasonic extraction with a power of 15KHz at 50°C for 90min, the filtrate was collected by filtration, and the ultrasonic extraction was repeated 3 times. The concentrate is freeze-dried to obtain hematoxylin extract;

[0063] 2) Centrifugal vine extract

[0064] Take the dried cane of the centering cane, pulverize, add 8 times the weight of 80% edible ethanol, and soak for 48 hours. Ultrasonic extraction of 15KHz power at 50°C for 90min, filtrate was collected by filtration, repeated ultrasonic extraction 3 times, combined filtrates, concentrated under reduced pressure at 50°C with a density of 1.15-1.20, and the concentrated solution was freeze-dried to obtain the extract of C.

[0065] 3) Take the Bisadinrone A prepared ...

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Abstract

The invention discloses a compound for resisting myocardial ischemia reperfusion injury and a composition for resisting myocardial ischemia reperfusion injury. According to a four-tower theory, the bisabolane sesquiterpenoids component obtained through separation is combined with the Dai medicine sappan wood extract and the mappianthus iodoratum extract according to a specific weight ratio, and the effect of resisting myocardial ischemia-reperfusion injury is remarkable. Non-curcumin components in turmeric are used for resisting myocardial ischemia reperfusion injury, the value of chemical components in turmeric is expanded, and the comprehensive value of traditional Dai medicines such as turmeric, sappan wood and mappianthus iodoratum can also be increased.

Description

technical field [0001] The invention specifically relates to a compound against myocardial ischemia-reperfusion injury, a Dai medicine composition and its application. Background technique [0002] Ischemic heart disease is currently the disease with the highest morbidity and mortality in the world. The clinical treatment plan is to restore coronary blood perfusion in a timely manner, but myocardial ischemia-reperfusion injury often occurs after blood supply is restored (Myocardial Ischemia-reperfusion Injury, MIRI), that is, the structural and functional damage of myocardial cells caused by ischemia is not improved by restoring blood supply, but aggravates or even causes irreversible heart failure. MIRI has become an important cause of high mortality after ischemic heart disease, and there is no ideal prevention and treatment method. It is an important direction of MIRI research to find safe and reliable active ingredients from ethnic medicines with definite curative effec...

Claims

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Application Information

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IPC IPC(8): C07D311/00C07C45/78C07C45/79C07C49/242A61K31/12A61K31/352A61P9/00A61K36/48A61K36/185
CPCC07D311/00C07C45/78C07C45/79C07C49/242A61K31/12A61K31/352A61P9/00A61K36/48A61K36/185C07C2601/16A61K2300/00Y02A50/30
Inventor 陈佳张莹莹李文春罗淑杰郑国伟
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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