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Application of folium artemisiae argyi essential oil in preparation of medicine for treating liver injury

A technology of argyi leaf essential oil and liver injury, which is used in pharmaceuticals, and the application field of argyi leaf essential oil in the preparation of medicines for treating liver damage, and achieves the effects of inhibiting activity, improving side effects, and small dosage.

Pending Publication Date: 2022-07-26
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the above status quo, a kind of drug that uses Artemisia argyi essential oil as a medicinal ingredient for preventing and / or liver damage has been developed, but there is no relevant report so far

Method used

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  • Application of folium artemisiae argyi essential oil in preparation of medicine for treating liver injury
  • Application of folium artemisiae argyi essential oil in preparation of medicine for treating liver injury
  • Application of folium artemisiae argyi essential oil in preparation of medicine for treating liver injury

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1 The effect of argyi leaf essential oil on bisphenol A-induced liver injury

[0024] Thirty-six healthy male C57BL / 6JGpt mice, weighing 18-20 g, were provided by Jiangsu Jicui Yaokang Biotechnology Co., Ltd. Mice were adaptively reared in the SPF animal room of the School of Pharmacy, Zhengzhou University, Henan Province for one week, and were divided into 4 groups by random number table method, with 9 mice in each group, as follows:

[0025] 1. Normal control group;

[0026] 2. Model control group;

[0027] 3. Artemisia argyi essential oil group;

[0028] 4. Positive control drug group

[0029] After the acclimation period, the drug was administered by intragastric gavage twice a day in the morning. First, the model control group, the argyi leaf essential oil group, and the positive control drug group were given bisphenol A (700 mg / kg) by gavage, and the normal control group was given the same amount of normal saline by gavage; 4.68 mg / kg), the positive c...

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Abstract

The invention belongs to the field of medicinal chemistry, and relates to application of folium artemisiae argyi essential oil in preparation of a medicine for treating liver injury. The invention provides a new application of folium artemisiae argyi essential oil as a unique effective component or a main effective component in preparation of a medicine for treating liver injury. The folium artemisiae argyi essential oil is applied to mice in an intragastric administration mode according to the weight of 4.68 mg / kg, after administration, the level of serum liver function enzyme can be reduced, the activity of xanthine oxidase in liver tissue can be inhibited, meanwhile, the activity of glutathione peroxidase 4 in the liver tissue can be up-regulated, the effect of treating liver injury can be achieved, and the folium artemisiae argyi essential oil has the advantages of being small in dosage and the like. According to the invention, a new application of the folium artemisiae argyi essential oil is developed, and a new direction is provided for improving the current situation that the side effect of the current medicine for treating liver injury is great.

Description

technical field [0001] The invention relates to pharmaceutical technology, belongs to the field of pharmaceutical preparations, and particularly relates to the application of argyi leaf essential oil in preparing medicines for treating liver damage. Background technique [0002] Liver is the most important organ of biotransformation in the body and plays an important role in maintaining the life activities of the body. Therefore, liver damage will cause serious harm to the body, ranging from fatty liver, and persistent aggravation will induce liver fibrosis and cirrhosis, and eventually lead to liver failure or liver cancer, seriously endangering human life and health. Bisphenol A (BPA) is the main ingredient used in the industry to synthesize polycarbonate (PC) and epoxy resins. In daily life, BPA is widely used in beverage containers, medical devices, household product adhesives and food packaging materials, and diet is considered to be the main route of human exposure. ...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61P1/16
CPCA61K36/282A61P1/16
Inventor 徐霞崔伟琪周慧张俊伟可钰陈迪屈凌波廖兴林
Owner ZHENGZHOU UNIV
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