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Application of LDLR (Low-Density Lipoprotein Receptor) in tumor immunotherapy and enhancement of immune effect of immune cells

A technology of cellular immunity and immune cells, which is applied in the direction of blood/immune system cells, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve the problems affecting the anti-tumor effect of immune cells, so as to improve the effect of tumor treatment and improve Killing effect, effect of enhancing anti-tumor activity

Pending Publication Date: 2022-07-26
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology

This type of tumor microenvironment will inhibit CD8 + The anti-tumor activity of T cells and immune cells, and in addition to the inhibition of the effector function of immune cells caused by tumor microenvironmental characteristics such as the lack of nutrients such as glucose and hypoxia, some studies have also found that the tumor microenvironment can affect the immune system through metabolic regulation. cellular antitumor effect

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  • Application of LDLR (Low-Density Lipoprotein Receptor) in tumor immunotherapy and enhancement of immune effect of immune cells
  • Application of LDLR (Low-Density Lipoprotein Receptor) in tumor immunotherapy and enhancement of immune effect of immune cells
  • Application of LDLR (Low-Density Lipoprotein Receptor) in tumor immunotherapy and enhancement of immune effect of immune cells

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[0035] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0036] It should be noted that the terminology used herein is for the purpose of describing specific embodiments only, and is not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural as well, furthermore, it is to be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates that There are features, steps, operations, devices, components and / or combinations thereof.

[0037] The present invention will now be further described with reference to specific examples. T...

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Abstract

The invention relates to application of LDLR in tumor immunotherapy and enhancement of immune effect of immune cells. The invention discloses the regulation effect of cholesterol metabolism related genes and proteins on the immune effect and antitumor activity of immune cells, and the regulation process does not completely depend on the uptake of cholesterol, thereby providing a new strategy and target for promoting tumor immunotherapy or enhancing the immune effect of the immune cells, and overcoming the technical prejudice in the prior art. The LDLR gene or the protein thereof can be used as a target spot to be regulated to improve the killing effect of corresponding CTL, and is applied to tumor immunotherapy to remarkably improve the antitumor activity of CTL cells and improve the tumor immunotherapy effect. In addition to directly acting on LDLR (Low Density Lipoprotein Receptor), the anti-tumor effect of CTL (Cytotoxic T Lymphocyte) can also be improved by inhibiting LDLR regulation related genes and proteins in tumor and / or immune cells, such as PCSK9. On the basis, an immune checkpoint blocker PD-1 antibody can be combined to further improve the immunotherapy effect.

Description

technical field [0001] The present invention relates to the field of immunotherapy, and more particularly, to the application of LDLR in tumor immunotherapy and enhancement of immune cell immune effect. Background technique [0002] Malignant tumor is a major disease that seriously endangers human life and health. At present, the treatment methods for malignant tumor mainly include surgery, radiotherapy, chemotherapy and immunotherapy. Among them, tumor immunotherapy aims to inhibit and kill tumor cells by mobilizing the body's immune system to provide anti-tumor efficacy, and is an important means of current tumor therapy. In particular, immunotherapy with T cells as the core has achieved certain curative effects in various types of tumors. [0003] T cells are an important component of the adaptive immune system, which can recognize specific antigens and mediate cellular immune responses, and play an important role in resisting foreign pathogen infection, tumor immunity a...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K48/00A61K38/17A61P35/00A61P37/04C07K14/705C12N5/0783
CPCA61K45/00A61K38/177A61K48/005A61P35/00A61P37/04C12N5/0636C07K14/705
Inventor 杨魏袁娟娟蔡婷郑晓君
Owner SOUTHERN MEDICAL UNIVERSITY
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