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Application of sodium butyrate in prevention and treatment of plateau polycythemia

A technology of sodium butyrate and erythroid cells, applied in the fields of extracellular fluid diseases, blood diseases, cardiovascular system diseases, etc.

Pending Publication Date: 2022-07-29
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, whether NaBu can play a role in the prevention and treatment of altitude sickness such as high altitude polycythemia has not been reported.

Method used

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  • Application of sodium butyrate in prevention and treatment of plateau polycythemia
  • Application of sodium butyrate in prevention and treatment of plateau polycythemia
  • Application of sodium butyrate in prevention and treatment of plateau polycythemia

Examples

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Embodiment 1

[0023] The specific implementation of this example is: adding different concentrations of sodium butyrate during the differentiation of human umbilical cord blood hematopoietic stem cells to erythroid, and detecting β-globin gene (HBB), γ-globin gene ( HBG) transcription and hemoglobin turnover, and relative changes in cell numbers during erythroid differentiation. The results showed that administration of sodium butyrate could significantly increase the expression ratio of HBG in (HBB+HBG), while inhibiting erythropoiesis.

[0024] 1. Low oxygen concentration

[0025] (1) carbon dioxide incubator used in the embodiment 2 The concentration is set to 3%;

[0026] (2) Treatment of hematopoietic stem cells: after resuscitation, hematopoietic stem cells were expanded under normoxia for 7 days, and then induced to differentiate into erythroid cells for 5 days and 2 days under normoxia and hypoxia in sequence;

[0027] (3) Control group (comparative example): the control group is...

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Abstract

The invention discloses application of sodium butyrate in preparation of a medicine for preventing and treating altitude sickness. The invention finds that sodium butyrate has an effect of promoting fetal hemoglobin expression, and the effect can be used for preventing, treating and improving altitude diseases such as high altitude polycythemia, high altitude pulmonary hypertension, high altitude pulmonary edema, high altitude cerebral edema and the like. The application limitation that sodium butyrate is only used as an anti-lymphoma drug at present is overcome.

Description

technical field [0001] The invention belongs to the technical field of drug research and development, in particular to the use of sodium butyrate in preventing and treating high altitude polycythemia. Background technique [0002] High altitude polycythemia, referred to as "hypererythemia", is a chronic high altitude disease caused by excessive compensatory hyperplasia of red blood cells caused by high altitude (high altitude) hypoxic environment. Compared with healthy people at the same altitude, patients with high altitude polycythemia have significantly more red blood cells and lower arterial oxygen saturation; increased red blood cells increase the oxygen carrying capacity, but increase blood viscosity and slow down blood flow , resulting in decreased perfusion of various organs and tissues throughout the body, further aggravating tissue hypoxia. The pathological damage of hypererythema is very extensive, manifested as congestion of various organs and tissues, blood sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P7/00A61P9/12A61P7/10A61P25/00
CPCA61K31/19A61P7/00A61P9/12A61P7/10A61P25/00
Inventor 吴丽颖李建曹炎陈迎何云凌王宇菲
Owner ACADEMY OF MILITARY MEDICAL SCI
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