The invention discloses a man-machine interaction method of an intelligent robot. The method at least includes the following execution steps that a control device gives a command to a 3D holographic projection device to generate an animated image with a holographic effect; an image sensor shoots the face image and limb action of an interaction object and transmits the face image and the limb action to the control device; a sound sensor and the image sensor are synchronous, and the sound of the interaction object is recorded and transmitted to the control device; the control device processes the information transmitted by the image sensor and the sound sensor, compared with prestored information, a command for control over the 3D holographic projection device and the sound device is generated, then the animated image with the holographic effect generates action, an execution mechanism is instructed to control the robot to generate or not to generate action, and meanwhile audio frequency corresponding to the action is played or not played. Holographic projection is integrated on the robot, man-machine interaction is carried out according to the sound, expression, limb action and other information fed back by the sensors, a traditional communication mode of a liquid crystal panel interaction interface is changed, man-machine interaction is more stereoscopic and vivid, and recreation interactivity is higher. Meanwhile, by the utilization of autonomous moving of the robot, obstacles can be intelligently avoided.