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Antithrombin nucleotides and proteins from horn fly

An anti-thrombin and protein technology, applied in the direction of peptide/protein components, anti-peptide structure protease inhibitor immunoglobulin, protease inhibitors, etc., can solve the problem that reocclusion is not universally effective

Inactive Publication Date: 2004-09-22
AUBURN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unfortunately, heparin has not proven to be universally effective in preventing reocclusion in patients with myocardial infarction with a degree of vessel occlusion greater than or equal to 70%, especially in patients with severe residual coronary stenosis

Method used

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  • Antithrombin nucleotides and proteins from horn fly
  • Antithrombin nucleotides and proteins from horn fly
  • Antithrombin nucleotides and proteins from horn fly

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Embodiment Construction

[0024] The present invention provides methods and compositions for preventing blood-sucking insects (blood-sucking) in livestock and for treating thrombosis in mammals. The composition comprises proteins from the salivary glands of the blood-sucking insect Hornfly, C. occidentalis, as described by Yeates et al. (1999) Annu. Rev. Entemol. 44:397-428. Western horn flies belong to the suborder Cyclorrhapha of the order Diptera. Additionally provided is the nucleotide sequence encoding the antithrombin protein. The protein is named thrombostatin, and its main function is to prevent blood clotting by inhibiting the activity of thrombin (factor II).

[0025] The present invention provides a purified protein with antithrombin activity, wherein said protein comprises the amino acid sequence listed in SEQ ID NO:2, SEQ ID NO:5, or SEQ ID NO:7.

[0026] The present invention also provides an isolated nucleotide sequence encoding a protein having antithrombin activity, wherein said prot...

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Abstract

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins. The proteins named thrombostasin is isolated from the salivary glands of Haematobia irritans. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly. The proteins of the invention are also useful in treatment of thrombosis.

Description

field of invention [0001] The present invention relates to veterinary vaccines for preventing livestock from being infected with blood-sucking insects and medical treatment of thrombosis. Background of the invention [0002] It is estimated that livestock production losses due to ectoparasitic infections exceed $2.26 billion annually in the United States (Byford et al. (1992) J. Anim. Sci, 70: 579-602). Among the 5-6 major arthropod pest species concerned, the western horn fly, Haematobia irritans linnaeus, is the most important and the most widespread. The economic impact of it on livestock production in the United States is estimated at $730.3 million per year. In Canada, control of this ectoparasite, which affects livestock production, could reduce losses by $71-107 million per year in 1977 dollars (Haufe and Weintraub (1985) Canadian Entomology (Can. Entomol.) 117:901-907). In South America, however, the economic impact of livestock production ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/00C07K14/81C12N1/21C12N15/15
CPCA61K2039/51A61K39/00C07K14/811
Inventor E·W·卡普M·S·卡普
Owner AUBURN UNIV
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