Method for extracting neohesperidin from young fruits of citrus aurantium
A technology for neohesperidin and plant acid, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of limited resources, low yield, and difficulty in collecting fresh sweet orange peels, and achieves the preparation of simple craftsmanship
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Embodiment 1
[0021] Weigh 1 kg of crude drug, add 8 liters of water, decoct for 2 hours, filter, extract 2 times of medicinal residues according to the above method, combine 3 times of water extracts, concentrate under reduced pressure until the weight of the concentrated solution is 1 kg, add 95% ethanol Make the alcohol content reach 75%, stir, stand still for 24 hours, filter the supernatant, concentrate the supernatant under reduced pressure until the weight of the concentrate is 2 kg, then extract the concentrate 5 times with water-saturated n-butanol, each time The amount of n-butanol used was 800 ml; the n-butanol extracts were combined, filtered, and 2000 ml of butanol was recovered by distillation under reduced pressure. The n-butanol concentrate was cooled and crystallized for 2 days, and the crystals were collected by filtration to obtain 198 grams of neohesperidin mixture.
[0022] The above neohesperidin mixture was dissolved in 800 ml of 90% ethanol, heated and refluxed at nor...
Embodiment 2
[0025] Put 250 kg of crude drug and 2000 liters of water into the extraction pot, decoct for 2 hours, then release the water extract, add 2000 liters of water to the crude drug residue, extract 2 times according to the above method, and concentrate the water extract 3 times under reduced pressure to the concentration of the concentrate. The weight is about 250 kg, add 95% ethanol to make the alcohol content reach 70%, fully stir, let stand for 24 hours, filter the supernatant, concentrate under reduced pressure until the weight of the concentrated solution is 500 kg, and then use saturated n-butane Alcohol extraction concentrated solution 5 times, each n-butanol consumption is 240 liters; Combine n-butanol extracts, filter, and recover butanol by vacuum distillation to about 600 liters of butanol concentrates, then cool and analyze the n-butanol concentrates After 2 days of crystallization, the crystals were collected by filtration to obtain 52.0 kg of neohesperidin mixture.
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Embodiment 3
[0029] The limes are collected, dried and crushed into a coarse powder for later use.
[0030] Weigh 1 kg of crude drug, add 8 liters of methanol, heat and reflux for 2 hours, filter, extract the medicinal residue twice according to the above method, combine the methanol extracts for 3 times, recover methanol, make the weight of the concentrated solution 2 kg, and then use n-butyl Extract the concentrated solution with alcohol 5 times, and use 800 ml of n-butanol each time; combine the n-butanol extracts, filter, recover 2000 ml of n-butanol, and filter the n-butanol concentrate to obtain 202.4 grams of neohesperidin mixture.
[0031] The above neohesperidin mixture was dissolved in 800 ml of 90% ethanol, heated to reflux for 2.5 hours, refrigerated and filtered, and the crystals were collected by filtration to obtain 103.3 grams of crude neohesperidin.
[0032] Add 10000 ml of water to 103.3 grams of crude neohesperidin, recrystallize, filter the crystals, wash with water, drai...
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