60 results about "Neohesperidin dihydrochalcone" patented technology

The invention relates to a method for simultaneously detecting six sweetening agents in a feed additive with a high performance liquid chromatograph. The six sweetening agents include A-K sugar, saccharin sodium salt, sodium cyclamate, aspartame, neotame and NHDC (Neohesperidin Dihydrochalcone). The method comprises the following steps: (1) preparing mixed standard working liquor; (2) preparing a sample solution to be detected; (3) using an instrument, namely the high performance liquid chromatograph; (4) adding ethyl alcohol in a used pretreatment method, such that a component NHDC difficultly dissolved in water in the sample is dissolved sufficiently; (5) drawing a standard curve; (6) analyzing a result. The method for simultaneously detecting the six sweetening agents in the feed additive with the high performance liquid chromatograph is simple in operation, accurate and reliable in detection result, good in repeatability, high in detection efficiency and excellent in separation effect, and can finish the detection of the six sweetening agents within 21 minutes while the pollution of a detection reagent to the environment in a detection process is reduced.

The invention relates to a synthesis method for neohesperidin dihydrochalcone. According to the synthesis method disclosed by the invention, neohesperidin dihydrochalcone is mainly prepared by carrying out hydrogenation on neohesperidin in an alkaline solution and hydrogen environment. The method is simple and easy to operate, low in environmental pollution, low in production, good in quality, high in yield, and suitable for industrialized production.

The invention discloses alpha-glucose-based new hesperidin dihydrochalcone. The compound is obtained by carrying out alpha-glucose-based reaction by using new hesperidin dihydrochalcone and dextrin as raw materials under the catalysis of glucosyltransferase. The alpha-glucose-based new hesperidin dihydrochalcone synthesized by the method can be widely used for the industries of foodstuff, medicaments, forages, daily chemicals and the like as a sweetener, a flavoring agent, a flavor enhancer and the like.

The invention discloses a hesperetin dihydrochalcone-7-O-glucoside, wherein the compound is obtained by generating a rhamnose deglycosylation reaction of new hesperidin dihydrochalcone in water or a water and organic solvent system under an enzyme action. The sweetness multiple of the hesperetin dihydrochalcone-7-O-glucoside prepared by the invention is about 1800 times of sucrose, and the hesperetin dihydrochalcone-7-O-glucoside can be widely used for industries of foods, medicines, feed, daily use chemicals and the like and used as a sweetening agent, a flavoring agent, a flavor enhancer and the like.

The invention belongs to the technical field of application of compound essences for cigarettes to cigarette fields, and discloses a compound essence for a cigarette. The compound essence for the cigarette comprises a wall material, a core material and an emulsifying agent, wherein the wall material is a mixture of sodium alginate and guar gum; the core material is a mixture of neohesperidin dihydrochalcone, leaf alcohol and leaf alcohol glycoside; the emulsifying agent is propylene glycol fatty acid ester. The invention also discloses a preparation method of the compound essence for the cigarette and a purpose of the compound essence for the cigarette for increasing the aroma of the cigarette; the compound essence for the cigarette can be used for restraining the biting smell of smoke and keeping the stability and the durability of the aroma of the cigarette, and the uniformity and the consistency, with the passage of time, of the release of the aroma.

The invention provides an edible low-calorie rare sugar sweetening agent composition. Specially, trehalose, erythritol, neohesperidin dihydrochalcone and steviol glycoside are compounded in a certainproportion, so that a sweetening agent composition being good in homogeneity, low in calorie, good in flavor and good in stability can be obtained. The sweetening agent composition has the characteristics of being pure in mouth feel and refreshing, and also has the efficacy of being low in calorie, balanced in blood sugar and high in stability, containing prebiotics, preventing dental caries, andthe like.

The invention discloses a method for synthesizing a 6''-O-lauroyl-neohesperidin dihydrochalcone ester on line by using lipase as a catalyst, which comprises the following steps: by using neohesperidin dihydrochalcone and vinyl laurate in a mole ratio of 1:(1-12) as raw materials, 0.5-1.0g of lipase Lipozyme RMIM as a catalyst and a tertiary amyl alcohol-DMSO (dimethyl sulfoxide) mixed solvent as a reaction solvent, uniformly filling the lipase Lipozyme RMIM into a reaction channel of a microfluidic channel reactor, wherein the internal diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4mm, and the reaction channel is 0.5-1.0m long; continuously introducing the raw materials and the reaction solvent into the reaction channel to perform acylation reaction, wherein the acylation reaction temperature is controlled at 40-55 DEG C, and the acylation reaction time is 20-40 minutes; and collecting the reaction solution on line, and carrying out conventional after-treatment on the reaction solution to obtain the 6''-O-lauroyl-neohesperidin dihydrochalcone ester. The method has the advantages of short reaction time, high selectivity and high yield.

The invention belongs to the technical field of chemical analysis of water bodies and discloses a method for simultaneously detecting seven artificial sweeteners in environmental water bodies by liquid chromatography-triple quadrupole tandem mass spectrometry. The method comprises the following steps: preparing seven artificial sweetener standards of acesulfame potassium, sodium cyclamate, saccharin sodium, sucralose, aspartame, neotame and neohesperidin dihydrochalcone into mother liquor of 1mg / mL respectively, then preparing a mixed standard solution with a concentration gradient, adding a 5ng / mL internal standard respectively, establishing a standard curve, carrying out separation with a C18 chromatographic column, using H2O, 5mMNH4Ac and 0.5mMTris-acetonitrile as a mobile phase, usinggradient elution to determine natures of separated components according to a retention time and a mass-charge ratio, and carrying out quantification by an internal standard method. An environmental water sample is filtered by a 0.45-micron filter membrane, is then purified and concentrated by a solid phase extraction method, and is finally detected and analyzed by liquid chromatography-triple quadrupole tandem mass spectrometry. The method provided by the invention can simultaneously carry out trace analysis on seven artificial sweeteners in environmental water bodies, and has a low detectionlimit, high sensitivity and good stability.

The invention discloses a preparation method of neohesperidin dihydrochalcone. The method comprises the steps of: subjecting hesperidin to hydrogenation synthesis of hesperidin dihydrochalcone, conducting enzymolysis on the hesperidin dihydrochalcone to generate hesperetin dihydrochalcone, and reacting the hesperetin dihydrochalcone with neohesperidose or analogue thereof to obtain the neohesperidin dihydrochalcone. The preparation method of neohesperidin dihydrochalcone adopts hesperidin as the raw material, substantial hesperidin exists in most citrus fruits, the extraction and refining steps are simple, and the price is only 1 / 10 that of neohesperidin. The method provided by the invention for the first time utilizes hesperidin for hydrogenation synthesis of hesperidin dihydrochalcone, then performs enzymolysis to produce hesperetin dihydrochalcone, and then carries out contact reaction with neohesperidose to obtain neohesperidin dihydrochalcone. The synthesis method has the advantages of simple steps and low raw material price, thus greatly reducing the production cost.

The invention provides a synthesis method of hesperitin dihydrochalcone, and gets rid of the dilemma that no literature records about the hesperitin dihydrochalcone synthesis process for reference ofmanufacturers exist at present. A one-pot method is adopted, neohesperidin is taken as an initial raw material, is placed in a sodium hydroxide solution to be subjected to ring opening and catalytic hydrogenation reduction to prepare neohesperidin dihydrochalcone, then an acid is added for neutralization, hydrolysis is performed under the acidic condition, and hesperitin dihydrochalcone is obtained.

The invention relates to a sweetening agent composition for food packaging paper, and belongs to the technical field of food packaging paper. The sweetening agent composition comprises the following components in parts by mass: 2-10 parts of a main sweetening agent, 1-5 parts of a sweetness modifier, 10-20 parts of a sweetening aid, 1-3 parts of an acidity regulator, 10-30 parts of water and 40-75parts of an ester additive, wherein the main sweetening agent is selected from one or more of neotame, alitame, neohesperidin dihydrochalcone, sucralose and stevioside. The food packaging paper is endowed with a sweet taste effect; meanwhile, the fragrance and sweetness of the food packaging paper are improved, after the food packaging paper makes contact with food, the taste of the food is combined, when the food is eaten, a consumer can directly feel the sweet taste and the faint scent of the sweetening agent, the salivation promoting feeling is improved, and the packaging is very effectivefor some food with the sweet taste as the main taste.

The invention discloses a curcumin composition capable of relieving a hangover and protecting the liver. The curcumin composition is mainly prepared from, by weight, 8-10 parts of curcumin, 20-25 parts of osmanthus flower essence, 6-8 parts of photinia glabra fruit, 3-5 parts of scabrous doellingeria rhizomes and roots, 2-3 parts of herb of pellionia repens and 0.02-0.05 part of neohesperidin dihydrochalcone. The obtained composition has the effects of removing toxicity, soothing the liver, invigorating the spleen and promoting body fluid secretion, not only can be used for relieving the hangover and protecting the liver, but also can obviously relive the parched mouth and scorched tongue symptoms occurring after drinking and has a good market prospect.

A carbonated beverage comprises the following raw materials per 1000mL: 2-3g citric acid, 0.2-0.8g sodium citrate, 5-10g fructo-oligosaccharide, 8-12mg neohesperidin dihydrochalcone and 0.2-1g pigment. A carbon dioxide content is not less than 3%. The carbonated beverage is prepared by water treatment, chilled water treatment, batching, premixing, filling, sealing, code spraying, light inspection, temperature return, labeling, water removal, inspection, warehousing and the like. In the carbonated beverage, fructo-oligosaccharide and neohesperidin dihydrochalcone serve as sweetening agents, so that a synergistic effect is enhanced, and a taste is mediated. The carbonated beverage is simple in process and good in taste, has multiple health-care effects at the same time, is an ideal fashionable drink, and is suitable for various human bodies with diabetes and adiposity.

The invention relates to a biological fermentation process of neohesperidin dihydrochalcone. The biological fermentation process comprises the following steps: by adopting neohesperidin as a startingraw material, carrying out biological-process hydrogenation reduction by utilizing a reduced coenzyme NADH to obtain the neohesperidin dihydrochalcone. The biological fermentation process of the neohesperidin dihydrochalcone has the beneficial effects that the process is simple, the operation is convenient, the production efficiency is high, and the product quality is good; the biological fermentation process is green, safe, healthy and reliable.

The invention discloses a pig feed phagostimulant, a preparation method and an application method . The pig feed phagostimulant comprises the following raw materials in percentage by mass: 15-25% of sodium glutamate, 0.2-0.5% of disodium 5'-guanylate, 0.2-0.6% of disodium 5'-inosinate, 0.3-0.7% of neohesperidin dihydrochalcone, 19.3-25% of chitosamine chelate and 55-65% of silicon dioxide. After being adding to pig feed and uniformly mixed, the pig feed phagostimulant can obviously improve the palatability of the pig feed, promote the ingestion of pigs continuously and improve the growth performance of the pigs.

The present invention relates to a sweetening composition comprising neohesperidin dihydrochalcone (NHDC) and gamma-cyclodextrin, to the use of the sweetening composition for sweetening ingestible products, namely, food products and pharmaceuticals, and to an ingestible product comprising the sweetening composition. Furthermore, the present invention also relates to the use of a composition comprising neohesperidin dihydrochalcone and a cyclodextrin selected from beta-cyclodextrin and gamma-cyclodextrin as taste-masking agent, to a process for masking unpleasant tastes in ingestible products, namely in food products and pharmaceuticals, and to ingestible products which comprise unpleasantly tasting substances and the taste-masking composition.

The invention discloses a Persicaria lapathifolia whitening lotion. The effective components of the lotion comprise neohesperidin dihydrochalcone, Persicaria lapathifolia extract and matrixes, and the matrixes are magnesium vitamin E phosphate, polyglyceryl-3 diisostearate, glycolic acid, linseed oil and hyaluronic acid respectively. The Persicaria lapathifolia extract is adopted as a main raw material, and neohesperidin dihydrochalcone and some matrixes are added, so the lotion has low price; and a mixture of the Persicaria lapathifolia extract and a small amount of neohesperidin dihydrochalcone has a very good synergistic effect on whitening, and greatly improves the whitening effect especially when a weight ratio of the Persicaria lapathifolia extract to neohesperidin dihydrochalcone is 8:1 to 10:1.

The invention discloses colla corii asini low-molecule peptide as well as a preparation method and application thereof, and belongs to the technical field of colla corii asini preparations. The collacorii asini low-molecule peptide is prepared by hydrolyzing colla corii asini with proteases and removing bitterness, wherein the proteases are natto kinase and acid protease. The colla corii asini low-molecule peptide prepared by the method is high in low-molecule peptide and high in biological availability. Adsorption is adopted with macroporous resins, so that the bitter components in the low-molecule peptide can be adsorbed, and the added plant extracts can regulate the bitterness and the fishy smell of the colla corii asini low-molecule peptide; and the added plant extracts are matched with stachyose, jujube vinegar and neohesperidin dihydrochalcone, so that the prepared colla corii asini low-molecule peptide preparation is moderate in sour and sweet degrees and free from fishy smelland bitterness. In addition, the colla corii asini low-molecule peptide can also improve the function of the stomach and the intestine, and prevent indigestion caused by taking of the colla corii asini.

The invention discloses a method for detecting the content of NHDC (Neohesperidin Dihydrochalcone) in a mixed type feed additive. The method comprises the following steps: detecting an NHDC standard solution of gradient concentration by using an LC (Liquid Chromatography) method, obtaining the peak area of an NHDC peak, and drawing a standard curve by using the concentration of the NHDC standard solution as the x-coordinate and the peak area as the y-coordinate; then extracting the NHDC in a sample by adopting a mobile phase, and combining ultrasonic treatment, thus obtaining a sample treating solution; detecting the sample treating solution under the same chromatographic condition of the NHDC standard solution, and converting, thus obtaining the content of the NHDC in the mixed type feed additive. According to the method for detecting the content of the NHDC in the mixed type feed additive, disclosed by the invention, the defect that the method for detecting the content of the NHDC in the mixed type feed additive is not provided at present is made up, detection can be carried out without complicated sample pretreatment, the peak detection is stable, and the method has the characteristics of sensitiveness, efficiency, precision and stability.

The application provides a compound disinfectant and a preparation method and application thereof. The main components of the disinfectant are chitosan and derivatives of the same, water extract of pomegranate peel, neohesperidin dihydrochalcone, glycerin, hyaluronic acid and peppermint extract. The compound disinfectant has the advantages of having highly effective immune effect on the physiological environment of condom lubricating oil, condom lubricants, liquid (foam) condoms and protective types of human susceptible parts, conducting efficient repair and prevention of gynecological diseases caused by sexual behavior to realize the protection of women, preventing diseases caused by various viruses such as sexually transmitted diseases through the use of virus-specific versions and transforming the pure physical protection of the original condom into a combination of biochemistry and physics to guarantee users' safety, and being capable of protecting the human body with daily immunity without toxicity for the human susceptible parts.

The invention discloses an anti-stress agent for relieving the transportation stress of livestock before being slaughtered and a preparation method of the anti-stress agent. The anti-stress agent is prepared from, by weight, 15-40%% of glucose, 5-25% of guanidinoacetic acid, 5-25% of glutamine, 2-15% of L-lysine, 5-10% of vitamin C, 1-12% of glycine betaine, 1-5% of potassium chloride, 1-5% of tannin, 1-5% of potassium citrate, 0-5% of calcium propionate, 0-5% of sodium butyrate, 0-5% of sodium diacetate, 0-5% of lactic acid and 1-2% of neohesperidin dihydrochalcone. The anti-stress agent is added into drinking water of the livestock according to the weight percentage of 0.01-5%, the livestock drinks the anti-stress agent 48 hours before loading and 2 hours after unloading, and does not drink the anti-stress agent during transportation. After the livestock drinks the anti-stress agent, the water content of meat can be obviously improved, the comprehensive stress reactions generated before slaughter are reduced, the weight loss is reduced, and economic losses are reduced.

The invention provides a preparation method of glycosylated neohesperidin dihydrochalcone. The method is characterized by comprising the specific steps that raw materials and glycosyl donors are put into a reaction buffer solution; the material and the solution are uniformly mixed; then glycosidase and glycosyltransferase are added to a reaction system, wherein the raw materials are an extract orconversion product of glycosylated neohesperidin dihydrochalcone and a derivative of the extract or conversion product. The solubility of the glycosylated neohesperidin dihydrochalcone prepared in themethod is improved, the utilization efficiency is improved, the use cost is reduced, the pre-sweetness and after-sweetness are improved, the taste is closer to that of sucrose, and therefore the application range of the glycosylated neohesperidin dihydrochalcone is wider.

The invention discloses a fresh and sweet high-power compound sweetening agent and a preparation process and application thereof, and belongs to the field of food additives, neohesperidin dihydrochalcone, disodium nucleotide (I + G), vitamin and yeast extract endow the sweetening agent with fresh and sweet flavor. The sweetening agent mainly comprises the following components: miraculin, citric acid, monopotassium glycyrrhizinate, ammonium glycyrrhizinate, tripotassium glycyrrhizinate, stevioside, mogroside, sucralose, neotame, neohesperidin dihydrochalcone, xylitol, erythritol, a yeast extract, disodium nucleotide (I + G), edible salt, vitamins and maltodextrin. The invention also discloses a preparation process of the fresh and sweet high-power compound sweetening agent, the process is simple, convenient and rapid, the sweetening agent can be quickly put into production, the sweetening agent can be applied to food, soy sauce, beverages, low-alcohol wine, dairy products or bakery products, and the sweetening agent can be prepared through scientific and reasonable compounding. Therefore, the obtained sweetening agent is prominent in fresh and sweet flavor, high in solubility, good in stability, high in safety and low in sweetness cost.

The invention relates to a pine pollen composition. The composition comprises the following components in parts by weight: 100 parts of pine pollen, 30 to 50 parts of tartary buckwheat, 5 to 10 parts of neohesperidin dihydrochalcone and 1 to 2 parts of table salt. The composition further comprises the following components in parts by weight: 50 to 70 parts of alpha-linolenic acid, 20 to 40 parts of docosahexaenoic acid and 20 to 40 parts of eicosapentaenoic acid. The pine pollen is ultra-micro pine pollen. The ultra-micro pine pollen is obtained by putting the pine pollen into an ultra-micro pulverizer and pulverizing at 30 DEG C for 40min. The pine pollen composition has the beneficial effects that the neohesperidin dihydrochalcone and the table salt are matched to use according to a ratio so that a bitter and astringent problem is radically solved; human bodies can more easily absorb the ultra-micro pine pollen provided by the invention; a formula ratio of the pine pollen and the tartary buckwheat have functions of improving cardiac and cerebral function, delaying ageing, maintaining beauty and keeping young, enhancing the immunity function, lowering blood glucose, lowering blood lipid and lowering cholesterol very well.

The invention discloses a synthesis process of neohesperidin. The synthesis process is characterized by comprising the following steps: 1) preparing phloroacetophenone-4'-beta-neohesperidoside; 2) purifying the phloroacetophenone-4'-beta-neohesperidoside; 3) preparing neohesperidin. The invention provides a neohesperidin synthesis process which has the following advantages: solvent and catalyst can be repeatedly used; yield is high; separation and purification of the intermediate product phloroacetophenone-4'-beta-neohesperidoside and neohesperidin are easy; and cost is low. In the aspect of biological activity, the product neohesperidin shows a wide pharmacologic action such as anti-bacteria, anti-inflammation, protection of the cardiovascular system, immunoregulation and the like. In addition, the product is an important raw material for synthesis of a sweetener neohesperidin dihydrochalcone.

The invention discloses whitening skin-care facial mask paste and a preparation method thereof. The whitening skin-care facial mask paste comprises, by weight, 0.1%-10% of neohesperidin dihydrochalcone, 0.1%-10% of baicalin, 0.1%-5% of Daidai fruit gum, 0.1%-2% of Daidai essential oil, 10%-20% of an organic solvent, 10%-15% of kaolin, 5%-10% of bentonite, 1%-5% of Tween 80 and the balance of water. Through combination of neohesperidin dihydrochalcone and baicalin according to the above weight ratio, the active site of tyrosinase can be destroyed and the tyrosinase does not act the melanin precursor tyrosine so that the formation of melanin is inhibited. The neohesperidin dihydrochalcone and baicalin can effectively inhibit the up-regulation of the MMP-1 gene caused by infrared rays, thereby effectively preventing premature aging of the human skin. The preparation method of the whitening skin-care facial mask paste utilizes easily available raw materials, realizes a low cost, has simpleprocesses and realizes industrial production.

The invention discloses a preparation method of a rabbit meat sausage. The preparation method comprises the following steps: cleaning and stirring rabbit meat and beef tallow to obtain a ground meat stuffing; then uniformly mixing water, dairy salt, nisin, thymol crystals, chitosan, sucralose, neohesperidin dihydrochalcone, sodium inosinate, tea polyphenol, dark soy sauce, cooking wine, star aniseed powder and ground cloves powder to obtain a pickling liquid; after that, immersing the ground meat stuffing into the pickling liquid; pickling for 5-8 h at the ordinary temperature; then heating for 0.5-1 h at 40-60 DEG C to obtain a pickled ground meat stuffing; crushing garlic powder and dill leaf; adding the crushed garlic powder and dill leaf into the pickled ground meat stuffing, and uniformly mixing; chopping for 5-10 min; then adding monascus pigment microcapsules, and chopping for 1-3 min to obtain a chopped meat stuffing; finally, injecting the chopped meat stuffing into a casing to obtain the rabbit meat sausage. As a color former (nitrite) is not added into the rabbit meat sausage, tea polyphenol is adopted for color protection and monascus pigment microcapsules (natural pigment) are adopted for color matching, the produced rabbit meat sausage is still excellent in color, and health potential hazards caused by nitrite are reduced.

The invention discloses a method for preparing novel aspartame based on exocarpium citri grandis and taking naringin as a raw material, and an application of aspartame. The method comprises the following specific method: obtaining naringin from by exocarpium citri grandis, then taking naringin as the raw material, and synthesizing the novel aspartame (neohesperidin dihydrochalcone). The problems of expensive sources of raw materials, low product yield and difficult repetition in the prior art are mainly solved. The method has the advantages of high extraction rate and high product content; theobtained novel aspartame has the advantages of high purity and industrialization; and meanwhile, the scientific basis is provided for scientific utilization and market development of exocarpium citrigrandis.

The present disclosure relates to antioxidant compositions comprising a high amount of stabilized neohesperidin dihydrochalcone. The antioxidant compositions may further include additional antioxidants, such as ferulic acid, and tocopherols. The compositions include at least 20 wt. % of one or more water-soluble solvents, such as propanediol, which contribute to the surprising solubility and stability of the compositions. The antioxidant properties of the compositions make them particularly effective for treating and protecting the skin. For example, the compositions are useful for protecting the skin from environmental insult.