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Method for simultaneously detecting seven artificial sweeteners in environmental water bodies by liquid chromatography-triple quadrupole tandem mass spectrometry

A triple quadrupole and tandem mass spectrometry technology is applied in the field of liquid chromatography-triple quadrupole tandem mass spectrometry for simultaneous detection of seven artificial sweeteners in environmental water, which can solve the problem of low detection sensitivity and poor stability of artificial sweeteners. problems, to achieve the effect of high sensitivity, good stability and safety

Pending Publication Date: 2018-06-01
JIANGHAN UNIVERSITY
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Problems solved by technology

[0006] The invention provides a liquid chromatography-triple quadrupole tandem mass spectrometry method for simultaneously detecting 7 kinds of artificial sweeteners in environmental water bodies, which solves the low detection sensitivity and poor stability of artificial sweeteners in environmental water bodies in the prior art question

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  • Method for simultaneously detecting seven artificial sweeteners in environmental water bodies by liquid chromatography-triple quadrupole tandem mass spectrometry
  • Method for simultaneously detecting seven artificial sweeteners in environmental water bodies by liquid chromatography-triple quadrupole tandem mass spectrometry
  • Method for simultaneously detecting seven artificial sweeteners in environmental water bodies by liquid chromatography-triple quadrupole tandem mass spectrometry

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Embodiment Construction

[0021] The embodiment of the present application provides a liquid chromatography-triple quadrupole tandem mass spectrometry method for simultaneously detecting 7 kinds of artificial sweeteners in environmental water bodies, so as to solve the problem of low detection sensitivity of artificial sweeteners in environmental water bodies in the prior art. Technical issues with poor stability.

[0022] In order to better understand the above technical solutions, the above technical solutions will be described in detail below in conjunction with the accompanying drawings and specific implementation methods. It should be understood that the embodiments of the present invention and the specific features in the embodiments are detailed descriptions of the technical solutions of the present application. , rather than limiting the technical solutions of the present application, the embodiments of the present application and the technical features in the embodiments can be combined without...

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Abstract

The invention belongs to the technical field of chemical analysis of water bodies and discloses a method for simultaneously detecting seven artificial sweeteners in environmental water bodies by liquid chromatography-triple quadrupole tandem mass spectrometry. The method comprises the following steps: preparing seven artificial sweetener standards of acesulfame potassium, sodium cyclamate, saccharin sodium, sucralose, aspartame, neotame and neohesperidin dihydrochalcone into mother liquor of 1mg / mL respectively, then preparing a mixed standard solution with a concentration gradient, adding a 5ng / mL internal standard respectively, establishing a standard curve, carrying out separation with a C18 chromatographic column, using H2O, 5mMNH4Ac and 0.5mMTris-acetonitrile as a mobile phase, usinggradient elution to determine natures of separated components according to a retention time and a mass-charge ratio, and carrying out quantification by an internal standard method. An environmental water sample is filtered by a 0.45-micron filter membrane, is then purified and concentrated by a solid phase extraction method, and is finally detected and analyzed by liquid chromatography-triple quadrupole tandem mass spectrometry. The method provided by the invention can simultaneously carry out trace analysis on seven artificial sweeteners in environmental water bodies, and has a low detectionlimit, high sensitivity and good stability.

Description

technical field [0001] The invention relates to the technical field, in particular to a liquid chromatography-triple quadrupole tandem mass spectrometry method for simultaneously detecting seven kinds of artificial sweeteners in environmental water bodies. Background technique [0002] Artificial sweeteners are a type of synthetic or semi-synthetic sucrose substitutes that are hardly metabolized in the human body, that is, only a small amount of heat is generated in the body, catering to modern consumers (especially diabetics, obese people, and dental caries patients) Dietary requirements, coupled with its low production costs, are widely used in food and beverages. Additionally, artificial sweeteners are added to pharmaceuticals and personal care products such as balms and lip balms. [0003] After a long period of widespread use, research investigations have shown that artificial sweeteners are ubiquitous in the environment. Among them, for example, acetaminophen ACE, cy...

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 周珍傅科涵廖雨梦梁勇
Owner JIANGHAN UNIVERSITY
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