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Method for preparing aspartame based on exocarpium citri grandis

A technology for turning tangerine red and sweetener, which is applied in the field of sweetener preparation, can solve the problems of low product yield, difficulty in repeating, expensive source of raw materials, etc., and achieve the effect of high yield and simple preparation method

Inactive Publication Date: 2018-07-27
GUANGDONG PHARMA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a method for preparing sweetener based on Huajuhong, which mainly solves the problems in the prior art that the source of raw materials is expensive, the product yield is low, and it is difficult to repeat, and at the same time it provides a new method for the scientific utilization of Huajuhong. direction

Method used

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  • Method for preparing aspartame based on exocarpium citri grandis
  • Method for preparing aspartame based on exocarpium citri grandis
  • Method for preparing aspartame based on exocarpium citri grandis

Examples

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Effect test

Embodiment 1

[0029] In this example, the operation method for preparing the novel sweetener neohesperidin dihydrochalcone is carried out according to the following three steps: Preparation of root bark acetophenone-4'-neohesperidin: weigh 8.0 g of naringin Place in a three-necked flask, add 120mL of sodium hydroxide or potassium hydroxide with a mass fraction of 15%, and pass through N 2 Heat to 145-150°C under inert gas protection and reflux for 2 hours. After cooling, add concentrated hydrochloric acid to adjust the pH to 6.0. A large amount of yellow-white precipitates are formed. Heat the mixture to 120°C, the solid dissolves, and naturally cools to precipitate crystals. Suction filtration, repeated washing with ice water , to obtain 5.6g product root bark acetophenone-4'-neohesperidin;

[0030] Preparation of neohesperidin: Weigh 4.76g of acetophenone-4'-neohesperidin and 1.52g of isovanillin, add 50mL of ethanol, stir at room temperature for 15min, then add catalyst tetrahydropyrrole...

Embodiment 2

[0033] The operation method for preparing the novel sweetener neohesperidin dihydrochalcone in this example is carried out according to the following three steps: Preparation of root bark acetophenone-4'-neohesperidin: weigh 8.0 g of naringin Place in a three-necked flask, add 120mL of sodium hydroxide or potassium hydroxide with a mass fraction of 15%, and pass through N 2 Heat to 145-150°C under inert gas protection and reflux for 2 hours. After cooling, add concentrated hydrochloric acid to adjust the pH to 6.0. A large amount of yellow-white precipitates are formed. Heat the mixture to 120°C, the solid dissolves, and naturally cools to precipitate crystals. Suction filtration, repeated washing with ice water , to obtain 5.7g product root bark acetophenone-4'-neohesperidin;

[0034] Preparation of neohesperidin: Weigh 4.76g of acetophenone-4'-neohesperidin and 1.52g of isovanillin, add 50mL of ethanol, stir at room temperature for 15min, then add catalyst tetrahydropyrrole ...

Embodiment 3

[0037]The operation method for preparing the novel sweetener neohesperidin dihydrochalcone in this example is carried out according to the following three steps: Preparation of root bark acetophenone-4'-neohesperidin: weigh 8.0 g of naringin Place in a three-necked flask, add 120mL of sodium hydroxide or potassium hydroxide with a mass fraction of 15%, and pass through N 2 Heat to 145-150°C under inert gas protection and reflux for 2 hours. After cooling, add concentrated hydrochloric acid to adjust the pH to 6.0. A large amount of yellow-white precipitates are formed. Heat the mixture to 120°C, the solid dissolves, and naturally cools to precipitate crystals. Suction filtration, repeated washing with ice water , to obtain 5.7g product root bark acetophenone-4'-neohesperidin;

[0038] The preparation of neohesperidin: Weigh 4.76g of acetophenone-4'-neohesperidin, 1.52g of isovanillin, add 50mL of ethanol, stir at room temperature for 15min, then add catalyst tetrahydropyrrole ...

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Abstract

The invention discloses a method for preparing novel aspartame based on exocarpium citri grandis and taking naringin as a raw material, and an application of aspartame. The method comprises the following specific method: obtaining naringin from by exocarpium citri grandis, then taking naringin as the raw material, and synthesizing the novel aspartame (neohesperidin dihydrochalcone). The problems of expensive sources of raw materials, low product yield and difficult repetition in the prior art are mainly solved. The method has the advantages of high extraction rate and high product content; theobtained novel aspartame has the advantages of high purity and industrialization; and meanwhile, the scientific basis is provided for scientific utilization and market development of exocarpium citrigrandis.

Description

Technical field: [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a method for preparing sweetener based on citrus red. technical background: [0002] Exocarpium citri grandis, also known as Huazhou orange, is the immature or mature dry outer peel of Eitrus grandis Osbeek or c. grandis osbeek, a plant of the genus Citrus in the family Rutaceae. Huajuhong is a unique traditional Chinese medicinal material in my country. Ancient records and modern research have shown that Huajuhong contains a variety of active ingredients, which have the functions of reducing phlegm, regulating qi, invigorating the spleen, eliminating food, and dispelling cold. With the extensive planting of Huajuhong and the saturation in the market as a traditional medicinal material, the rational and scientific development and utilization of Huajuhong has become particularly important. Naringin, as the main component of tangerine flavonoids, has a high...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/00
CPCC07H1/00C07H15/203
Inventor 孔繁晟陈钊圣
Owner GUANGDONG PHARMA UNIV
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