Biological fermentation process of neohesperidin dihydrochalcone

A technology of hesperidin dihydrochalcone and bio-fermentation, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of easy safety problems, dangerous process steps, low calorific value, etc., and achieve High production efficiency, simple process and convenient operation

Inactive Publication Date: 2018-06-29
SHANDONG BENYUE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Neomethylhesperidin dihydrochalcone is a safe low-calorie sweetener with good thermal stability. It is widely used in the fields of food, medicine and feed. The traditional process adopts the chemical method of neohesperidin to catalyze hydrogenation , to produce new methyl hesperidin dihydrochalcone, because the dangerous chemical hydrogen gas is used in the conversion process from neohesperidin to new methyl hesperidin dihydrochalcone, and the process steps are dangerous and easy to produce safety Due to policy restrictions, there is an urgent need for a safe and healthy hydrogenation reduction method to solve the current development bottleneck problem, and NADH (nicotinamide aden

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add 100 grams of neohesperidin into 1000 grams of aqueous solution containing 2 grams of sodium hydroxide, stir evenly and then heat up to 50°C, add 50 grams of NADH (nicotinamide adenine dinucleotide) into the dissolved reaction solution , the stirring speed is 150 rpm, stirring and fermenting for 10 hours, increasing the temperature to 70°C, then cooling to 10°C, centrifuging and throwing the material, the yield is 98%, and the purity of the product is 98% by HPLC

Embodiment 2

[0028] Add 100 grams of neohesperidin to 1000 grams of aqueous solution containing 2 grams of sodium hydroxide, stir evenly and then heat up to 50°C, add 100 grams of NADH (nicotinamide adenine dinucleotide) into the dissolved reaction solution , slowly stirred and fermented for 10 hours, raised the temperature to 70°C, then lowered the temperature to 10°C, centrifuged and dumped the material, the yield was 95%, and the purity of the product was 98% by HPLC

Embodiment 3

[0030] Add 100 grams of neohesperidin to 1000 grams of aqueous solution containing 2 grams of sodium hydroxide, stir evenly and then heat up to 50°C, add 20 grams of NADH (nicotinamide adenine dinucleotide) into the dissolved reaction solution , slowly stirred and fermented for 10 hours, raised the temperature to 70°C, then lowered the temperature to 10°C, centrifuged and dumped the material, the yield was 80%, and the purity of the product was 98% by HPLC

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PUM

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Abstract

The invention relates to a biological fermentation process of neohesperidin dihydrochalcone. The biological fermentation process comprises the following steps: by adopting neohesperidin as a startingraw material, carrying out biological-process hydrogenation reduction by utilizing a reduced coenzyme NADH to obtain the neohesperidin dihydrochalcone. The biological fermentation process of the neohesperidin dihydrochalcone has the beneficial effects that the process is simple, the operation is convenient, the production efficiency is high, and the product quality is good; the biological fermentation process is green, safe, healthy and reliable.

Description

technical field [0001] The invention relates to the field of food additives, in particular to a biofermentation process of neomethylhesperidin dihydrochalcone. Background technique [0002] Neomethylhesperidin dihydrochalcone is a safe low-calorie sweetener with good thermal stability. It is widely used in the fields of food, medicine and feed. The traditional process adopts the chemical method of neohesperidin to catalyze hydrogenation , to produce new methyl hesperidin dihydrochalcone, because the dangerous chemical hydrogen gas is used in the conversion process from neohesperidin to new methyl hesperidin dihydrochalcone, and the process steps are dangerous and easy to produce safety Due to policy restrictions, there is an urgent need for a safe and healthy hydrogenation reduction method to solve the current development bottleneck problem, and NADH (nicotinamide adenine dinucleotide) itself is a reduced coenzyme, which can safely and efficiently complete hydrogenation redu...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/00
CPCC07H1/00C07H15/203
Inventor 王振东陈良朱思明
Owner SHANDONG BENYUE BIOTECH
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