Synthesis method of hesperitin dihydrochalcone

A technology of neohesperidin dihydrochalcone and dihydrochalcone, which is applied in the field of synthesis of hesperetin dihydrochalcone, and can solve the problem of lack of resources and research on the synthesis process of hesperetin dihydrochalcone Few other problems, to achieve the effect of abundant sources, easy access, and pure taste

Inactive Publication Date: 2020-04-03
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is very little research on the synthesis process of hesperetin dihydrochalcone, and resources are scarce. At present, a synthesis process with simple process, high yield and high content has not been found for direct use by manufacturers.

Method used

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  • Synthesis method of hesperitin dihydrochalcone

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A kind of synthetic method of hesperetin dihydrochalcone, comprises the following steps:

[0031] 1) Preparation of neohesperidin dihydrochalcone

[0032] Dissolve 100g of raw material neohesperidin in 1000g of sodium hydroxide solution with a mass concentration of 5%, then add 7g of ternary nickel catalyst, stir evenly, heat up to 40°C, and carry out hydrogenation reaction for 3h to obtain A solution of neohesperidin dihydrochalcone;

[0033] 2) Preparation of crude hesperetin dihydrochalcone

[0034] Use hydrochloric acid to adjust the pH of the solution containing neohesperidin dihydrochalcone to 2, heat up and reflux for 5 hours to complete hydrolysis, cool down to below 10°C, crystallize for 24 hours, filter and dry to obtain hesperetin dihydrochalcone crude ketone;

[0035] Step 3) prepare hesperetin dihydrochalcone boutique

[0036] The hesperetin dihydrochalcone crude product obtained in step 2) was recrystallized with 50% ethanol at 10 times its volume mass...

Embodiment 2

[0038] A kind of synthetic method of hesperetin dihydrochalcone, comprises the following steps:

[0039] 1) Preparation of neohesperidin dihydrochalcone

[0040] Dissolve 50g of raw material neohesperidin in 500g of sodium hydroxide solution with a mass concentration of 5%, then add 3.5g of ternary nickel catalyst, stir evenly, heat up to 40°C, and carry out hydrogenation reaction for 3h to obtain solutions containing neohesperidin dihydrochalcone;

[0041] 2) Preparation of crude hesperetin dihydrochalcone

[0042] Use hydrochloric acid to adjust the pH of the solution containing neohesperidin dihydrochalcone to 2, heat up and reflux for 5 hours to complete hydrolysis, cool down to below 10°C, crystallize for 24 hours, filter and dry to obtain hesperetin dihydrochalcone crude ketone;

[0043] Step 3) prepare hesperetin dihydrochalcone boutique

[0044] The hesperetin dihydrochalcone crude product obtained in step 2) was recrystallized with 50% ethanol at 10 times its volu...

Embodiment 3

[0046] A kind of synthetic method of hesperetin dihydrochalcone, comprises the following steps:

[0047] 1) Preparation of neohesperidin dihydrochalcone

[0048] Dissolve 150g of raw material neohesperidin in 1500g of sodium hydroxide solution with a mass concentration of 5%, then add 10.5g of ternary nickel catalyst, stir evenly, heat up to 40°C, and carry out hydrogenation reaction for 3h to obtain solutions containing neohesperidin dihydrochalcone;

[0049] 2) Preparation of crude hesperetin dihydrochalcone

[0050] Use hydrochloric acid to adjust the pH of the solution containing neohesperidin dihydrochalcone to 2, heat up and reflux for 5 hours to complete hydrolysis, cool down to below 10°C, crystallize for 24 hours, filter and dry to obtain hesperetin dihydrochalcone crude ketone;

[0051] Step 3) prepare hesperetin dihydrochalcone boutique

[0052] The hesperetin dihydrochalcone crude product obtained in step 2) was recrystallized with ethanol whose volume concentr...

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Abstract

The invention provides a synthesis method of hesperitin dihydrochalcone, and gets rid of the dilemma that no literature records about the hesperitin dihydrochalcone synthesis process for reference ofmanufacturers exist at present. A one-pot method is adopted, neohesperidin is taken as an initial raw material, is placed in a sodium hydroxide solution to be subjected to ring opening and catalytic hydrogenation reduction to prepare neohesperidin dihydrochalcone, then an acid is added for neutralization, hydrolysis is performed under the acidic condition, and hesperitin dihydrochalcone is obtained.

Description

technical field [0001] The invention belongs to the technical field of food additives, in particular to a method for synthesizing hesperetin dihydrochalcone. Background technique [0002] Due to the increasing proportion of diabetics in the world, the demand for sugar in the human diet is constantly undergoing new changes, and the exploration of natural low-calorie sweeteners is constantly deepening. Health provides security. Healthy and natural low-calorie sweeteners are extracted from plants and produced by biological methods or simple reduction reactions. They have good taste, low additions, and low calories. They can not only satisfy people's pursuit of sweetness, but also reduce the risk of excessive The health hazards caused by ingesting sugar, therefore, natural low-calorie sweeteners are safe, easy to accept by consumers, and are very popular in the market. At present, natural high-intensity sweeteners mainly include stevioside, glycyrrhizin, mogroside, aspartame, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/60C07C49/84
CPCC07C45/60C07H1/00C07H15/203C07C49/84C07C45/64
Inventor 郭文华肖金霞赵景辉
Owner SHAANXI JIAHE PHYTOCHEM
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