Genistein-3'-sodium sulfonate, dimethylation daidzein-3'-sodium sulfonate, their preparing process and pharmaceutical use

A technology for bis-methylated daidzein and genistein, which is used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of low water solubility and fat solubility, affecting drug availability and effective time , large dosage and other problems, to achieve the effect of low production cost, good anti-hypoxia effect and simple process
CN1275958CInactive Publication Date: 2006-09-20SHAANXI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHAANXI NORMAL UNIV
Publication Date
2006-09-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a genistein-3'-sodium sulfonate, dimethylation daidzein-3'-sodium sulfonate and their preparing process comprising the steps of, charging reactants genistein or dismethylation daidzein into the dissolvent, charging sulphonating agent, subjecting the reactant and sulphonating agent to chemical reaction, separating the mixture by means of the conventional methods and purifying. The invention also provides a medicament and composition for treating cardiovascular and cerebrovascular diseases.
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Description

technical field

[0001] The invention belongs to the technical field of heterocyclic compounds, and specifically relates to a heterocyclic compound containing a six-membered ring without hydrogenation, with an oxygen atom as the only ring heteroatom, and fused with other rings. Background technique

[0002] Soy isoflavones are natural extracts of soybeans, which bind to estrogen receptors and induce a class of phytochemicals with weak estrogen-like effects, among which genistein and daidzein are the main physiological functions. Genistein has obvious effects of anti-tumor, lowering blood fat, anti-atherosclerosis and improving women's menopausal symptoms. In recent years, genistein is also a nutritional ingredient that has been extensively studied. It has the functions of preventing tumors, regulating menstruation and other health benefits in the human body. Epidemiological studies have shown that the incidence of breast cancer and prostate cancer in East Asia is much lower ...

Claims

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