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Methods for regulating the condition of mammalian keratinous tissue via topical application of phytosterol compositions

A technology of mammals and phytosterols, which can be used in drug combinations, pharmaceutical formulas, cosmetic preparations, etc., and can solve problems such as weak resistance to mechanical effects

Inactive Publication Date: 2002-05-29
THE PROCTER & GAMBNE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result of this thinning, a reduction of the cells and capillaries supplying the skin and a flattening of the dermal-epidermal junction results in a weak mechanical resistance of the junction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0180] Methods of preparation of the compositions of the present invention are generally conventional methods known in the art of preparing topical compositions. These methods generally involve mixing the ingredients into a relatively uniform state in one or more steps, with or without heating, cooling, vacuum, and the like. Ways to Regulate Skin Condition

[0181] The compositions of the present invention are useful for regulating the condition of various mammalian keratinous tissues. Such regulation of keratinous tissue condition includes prophylactic and therapeutic regulation. More specifically, such conditioning methods include, but are not limited to, densification of keratinous tissue (i.e., structuring of the epidermis and / or dermis and / or subcutaneous layers of the skin and, where applicable, of the nails and hair shaft), and preventing, Preventing, hindering and / or treating skin atrophy in mammals; preventing, hindering and / or treating the appearance of dark circle...

Embodiment 1

[0191] Add phase C mixture to phase B mixture and mix. The resulting mixture was then added to the Phase A mixture with stirring, cooled in a cold water bath and ground, then continued stirring. Once the temperature reached 40°C, the mixture was removed from the bath with continuous stirring.

[0192] Separately, mix Phase D ingredients with stirring until dissolved, then add to the mixture of A-C materials.

[0193] Separately, mix Phase E ingredients with agitation until smooth and continuous, then add to the mixture of A-D materials. Spices were added to the mixture, followed by NaOH. Adjust the pH to 5.5.

[0194] The composition is applied to the subject's intrinsically aged, sagging or photodamaged facial skin in an amount of 2 mg composition / cm 2 Skin, once or twice a day for at least 3-6 months to increase skin density and relieve skin sagging.

Embodiment 2

[0197] Add water in a suitable vessel to form the aqueous phase as follows: Add glycerin to water with stirring. To this mixture was added methylparaben dissolved in benzyl alcohol with stirring. To this mixture was added EDTA with stirring.

[0198] The silicone phase is formed by adding and stirring the silicone fluid and stigmasterol in another suitable vessel.

[0199] Slowly add the aqueous phase to the silicone phase with stirring to form an emulsion.

[0200] The resulting composition is applied to the subject's inherently aged, sagging or photodamaged facial skin in an amount of 2 mg composition / cm 2 Skin, once or twice a day for at least 3-6 months to increase skin density and relieve skin sagging.

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PUM

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Abstract

The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of one or more phytosterols selected from the group consisting of beta-sitosterol, campesterol, brassicasterol, Delta5-avennasterol, lupenol, alpha-spinasterol, stigmasterol, their derivatives, and combinations thereof; and b) a dermatologically acceptable carrier for the phytosterol. In additional embodiments, the above composition is suitable for thickening skin and preventing, retarding, and / or treating atrophy of mammalian skin, preventing, retarding, and / or treating the appearance of dark, under-eye circles and / or puffy eyes, preventing, retarding, and / or treating sallowness of mammalian skin, d) preventing and / or retarding tanning of mammalian skin, regulating and / or reducing the size of pores in mammalian skin, desquamating, exfoliating, and / or increasing turnover of mammalian skin, regulating oily / shiny appearance, preventing / retarding post-inflammatory hyperpigmentation in mammalian skin, and preventing and / or treating the appearance of cellulite in mammalian skin.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 60 / 134,397, filed May 17,1999. technical field [0003] The present invention relates to a method of regulating the condition of mammalian keratinous tissue using defined phytosterols, wherein the method comprises a) densifying the skin, preventing, retarding and / or treating atrophy of mammalian skin, b) preventing, retarding and / or treating The appearance of dark circles and puffy eyes, c) preventing, hindering and / or treating the appearance of sallow complexion in mammals, d) preventing, hindering and / or treating tanning of mammalian skin, e) desquamation, peeling of mammalian skin and / or increase turnover rate, f) regulate and / or reduce mammalian skin pore size, g) regulate mammalian skin oily and / or shiny appearance, h) prevent, retard and / or treat post-inflammatory hyperpigmentation, and i) Pre...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K8/06A61K8/33A61K8/36A61K8/49A61K8/63A61K31/353A61K31/455A61K31/575A61K31/60A61P17/00A61P17/16A61Q19/00A61Q19/02A61Q19/06A61Q19/08
CPCA61Q19/00A61K8/63A61Q19/06A61Q19/08A61Q19/02A61P17/00A61P17/16
Inventor J·C·庄J·E·欧博龙D·L·比赛特
Owner THE PROCTER & GAMBNE CO
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