Interleukin-17 related mammalian cytokines, polynucleotides encoding them. uses

A polynucleotide, mammalian technology, applied in the field of protein-related compositions, can solve problems such as uncontrollable cell development or abnormal or inappropriate physiological regulation, immune system hindering biological attack normal defense mechanisms, etc.
CN1357042AInactive Publication Date: 2002-07-03SCHERING AG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SCHERING AG
Publication Date
2002-07-03
Estimated Expiration
Not applicable · inactive patent
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Abstract

CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
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Description

field of invention

[0001] The present invention relates to protein-related compositions that play a role in controlling the physiology, development and differentiation of mammalian cells, such as cells of the mammalian immune system. In particular, the invention provides nucleic acids, proteins, antibodies, and mimetics that modulate cellular physiology, development, differentiation, or function of various cell types, including hematopoietic cells. Background of the invention

[0002] The immune system of vertebrates consists of many organs and several different cell types. The two main cell types include myeloid and lymphoid lineages. Within the lymphoid cell lineage are B cells and T cells, with B cells originally identified as differentiated in the fetal liver or adult bone marrow and T cells originally identified as differentiated in the thymus. See, eg, Paul (ed., 1998) Fundamental Immunology (4th ed.) Raven Press, New York.

[0003] In many ways...

Claims

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