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Interleukin-17 related mammalian cytokines, polynucleotides encoding them. uses

A polynucleotide, mammalian technology, applied in the field of protein-related compositions, can solve problems such as uncontrollable cell development or abnormal or inappropriate physiological regulation, immune system hindering biological attack normal defense mechanisms, etc.

Inactive Publication Date: 2002-07-03
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a lack of understanding of how the immune system is regulated or differentiated has hampered the ability to favorably modulate normal defense mechanisms against biological attack
Consequently, it remains impossible to control medical conditions characterized by abnormal or inappropriate developmental or physiological regulation of the associated cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0261] Example I. General method

[0262] In Maniatis et al. (1982) Molecular Cloning: A Laboratory Manual Cold Spring Harbor Laboratory, Cold Spring Harbor Press; Sambrook et al. (1989) Molecular Cloning: A Laboratory Manual (2nd Edition) Volumes 1-3, CSH Press, NY; Ausubel et al. , Biology Greene Publishing Associates, Brooklyn, NY; or Ausubel et al. (1987 and supplements) Current Protocols in Molecular Biology Greene / Wiley, New York; Innis et al. (ed. 1990) PCR Protocols: A Guide to Methods and Applications Academic Press, N.Y.; and Many of these standard methods are described or cited in Kohler et al. (1995) Quantitation of mRNA by Polymerase Chain Reaction Springer-Verlag, Berlin. Methods for protein purification include methods such as ammonium sulfate precipitation, column chromatography, electrophoresis, centrifugation, crystallization, and others. See, for example, Ausubel et al. (1987 and regular supplements); Deutscher (1990) "Guidelines for...

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PUM

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Abstract

CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.

Description

field of invention [0001] The present invention relates to protein-related compositions that play a role in controlling the physiology, development and differentiation of mammalian cells, such as cells of the mammalian immune system. In particular, the invention provides nucleic acids, proteins, antibodies, and mimetics that modulate cellular physiology, development, differentiation, or function of various cell types, including hematopoietic cells. Background of the invention [0002] The immune system of vertebrates consists of many organs and several different cell types. The two main cell types include myeloid and lymphoid lineages. Within the lymphoid cell lineage are B cells and T cells, with B cells originally identified as differentiated in the fetal liver or adult bone marrow and T cells originally identified as differentiated in the thymus. See, eg, Paul (ed., 1998) Fundamental Immunology (4th ed.) Raven Press, New York. [0003] In many ways...

Claims

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Application Information

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IPC IPC(8): G01N33/53A61K38/00C07K14/54C07K16/24C12N1/15C12N1/19C12N1/21C12N5/10C12N15/09C12N15/24C12P21/02C12R1/91
CPCC07K14/54A61K38/00C12N15/11
Inventor D·M·戈曼J·F·巴赞R·A·卡斯特莱恩
Owner SCHERING AG
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