Double-layer slow release ibuprofen and pseudoephedrine hydrochloride tablet

A slow-release tablet, double-layer technology, applied in the directions of drug delivery, anhydride/acid/halide active ingredients, non-central analgesics, etc. Response, long-lasting effect of drug effect

Inactive Publication Date: 2003-10-29
黄振华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of ibuprofen and pseudoephedrine double-layer sustained-release tablet, on the basis of ibuprofen and pseudoephedrine capsule, prepare a kind of sustained-release tablet, and be ibuprofen and pseudoephedrine hydrochloride Sustained-release granules are prepared separately, and compressed twice to form double-layer tablets, which not only solves the problem of taking too many times and inconvenient taking, but also separates the two main ingredients to avoid physical and chemical reactions, and make the sustained-release preparation more effective. more durable and stable

Method used

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Embodiment Construction

[0009] Ibuprofen double-layer sustained-release tablet, which includes ibuprofen sustained-release drug raw material and pseudoephedrine hydrochloride sustained-release drug raw material, which is compressed twice to form a double-layer tablet, and the main drug raw material of ibuprofen is distributed in the ibuprofen sustained-release layer The ratio is: 100-500 mg, and the ratio of the main drug raw material of pseudoephedrine hydrochloride distributed in the pseudoephedrine hydrochloride slow-release layer is: 20-70 mg. The ratio of the ibuprofen main drug raw material distributed in the ibuprofen slow-release layer is 300 mg, and the ratio of the main drug raw material of pseudoephedrine hydrochloride distributed in the pseudoephedrine hydrochloride slow-release layer is 45 mg.

[0010] ibuprofen

100~500mg

lactose

100mg

pregelatinized starch

100mg

Hydroxypropyl methylcellulose 50CPS

100mg

30% ethanol

100mg

Mag...

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PUM

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Abstract

A slow-releasing dual-layer ibuprofen-pseudoephedrine tablet is prepared from slow-releasing ibuprofen and slow-releasing pseudoephedrine hydrochloride through tabletting twice.

Description

Technical field: [0001] The invention relates to medicines, which is a double-layer sustained-release tablet of buprofen and pseudoephedrine. Background technique: [0002] Ibuprofen is a phenylpropionic acid non-steroidal anti-inflammatory analgesic, which has strong anti-inflammatory, anti-rheumatic, antipyretic and analgesic effects, and is used for rheumatoid arthritis. Its anti-inflammatory, analgesic, and antipyretic effects are similar to aspirin and phenylbutazone, and better than acetaminophen, but its side effects on the gastrointestinal tract are lighter and are easily tolerated by patients. Pseudoephedrine hydrochloride has the effect of selective vasoconstriction, eliminates congestion and swelling of nasopharyngeal mucosa, relieves nasal congestion symptoms, and has little effect on systemic blood vessels, heart rate and blood pressure. There are Buluo pseudoephedrine tablets and Buluo pseudoephedrine capsules in clinical use, which are used to treat fever, he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/19A61P29/00
Inventor 黄振华
Owner 黄振华
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