Chinese medicinal composition for anti-cancer and analgesia, its preparation method and its application in the preparation of product and medicine for treating cancer and analgesia

A composition and technology of traditional Chinese medicine, applied in the field of preparation of anti-cancer products and analgesic drugs, can solve the problems of small toxic and side effects, toxic and side effects, lack of systemic adjustment in disease treatment, etc.

Inactive Publication Date: 2004-03-03
SHANGHAI ZHONGYAO BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine has its limitations. It regards the human body simply as a substance and continuously dissects it into monomers. Therefore, it lacks the concept of systemic adjustment in the treatment of diseases.
Moreover, synthetic drugs have obvious

Method used

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  • Chinese medicinal composition for anti-cancer and analgesia, its preparation method and its application in the preparation of product and medicine for treating cancer and analgesia
  • Chinese medicinal composition for anti-cancer and analgesia, its preparation method and its application in the preparation of product and medicine for treating cancer and analgesia
  • Chinese medicinal composition for anti-cancer and analgesia, its preparation method and its application in the preparation of product and medicine for treating cancer and analgesia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Weigh raw materials according to the following ratio (kg)

[0094] Ganoderma lucidum 3 Dongling grass 1.8

[0095] Corydalis 1.8 Scutellaria baicalensis 1.5 Fangji 1.2

[0096] Notoginseng 0.9 Licorice 0.9

[0097] Mix the above-mentioned raw materials, grind into coarse powder of traditional Chinese medicine, and divide the coarse powder into five equal parts for use in the following 1)-5) extraction steps;

[0098] 1) Extraction of alkaloids:

[0099] i) Diafiltering or leaching several times with 0.1% hydrochloric acid ethanol (95%) solution of the Chinese medicine coarse powder obtained above to obtain an acidic ethanol extract;

[0100] ii) concentrating under reduced pressure to obtain a concentrate;

[0101] iii) acidic water (pH=4-5) washing, in one embodiment, preferably the acidic water is frozen overnight, filtered to obtain a residue, the residue is washed with acidic water (pH=4-5) to obtain acidic water liquid;

[0102] iv) adding ammonia water to th...

Embodiment 2

[0120] 1) extract baicalin:

[0121] i) Add 10 times (volume) amount of water to 2 kilograms of Scutellaria baicalensis and decoct for 1 hour, filter;

[0122] ii) Adjust the filtrate to pH 2 with acid, keep it at 80°C for 30 minutes, and centrifuge to precipitate; add water and stir the precipitate evenly, add alkali to adjust the pH to neutral, then add 5 times (volume) of ethanol, and filter;

[0123] iii) Add hydrochloric acid to the filtrate, adjust the pH to 2, stir, keep at 80°C for 30 minutes, and filter;

[0124] iv) The obtained precipitate is washed with water and 50% ethanol respectively, and then washed with 95% ethanol or recrystallized to obtain baicalin.

[0125] 2) extract notoginseng saponins:

[0126] i) 40% methanol was used to extract the soluble components in 1.5 kg of Panax notoginseng coarse root powder, the methanol extract was concentrated under reduced pressure, and 5 times (volume) of water was added to the residue;

[0127] ii) The aqueous solut...

Embodiment 3

[0155] 1) extract baicalin:

[0156] i) Add 10 times (volume) amount of water to 1 kilogram of Scutellaria baicalensis and decoct for 1 hour, filter;

[0157] ii) Adjust the filtrate to pH 2 with dilute hydrochloric acid, keep it at 80°C for 30 minutes, and centrifuge to precipitate; add water and stir the precipitate evenly, add alkali to adjust the pH to neutral, then add 3 times (volume) of ethanol, and filter;

[0158] iii) Add hydrochloric acid to the filtrate, adjust the pH to 2, stir, keep at 80°C for 30 minutes, and filter;

[0159] iv) The obtained precipitate was washed with water and 50% ethanol respectively, and then washed with 95% ethanol or recrystallized to obtain baicalin.

[0160] 2) extract notoginseng saponins:

[0161] i) 40% methanol was used to extract the soluble components in 0.5 kg of root powder of Panax notoginseng, the methanol extract was concentrated under reduced pressure, and 5 times (volume) of water was added to the residue;

[0162] ii) T...

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Abstract

An anticancer and antalgic Chinese medicine is prepared from 7 Chinese-medicinal materials including ganoderma, cordalis tuber, notoginseng, liquorice root, etc through extracting their active components. Its advatnages are high curative effect and low by-effect.

Description

(1) Technical field [0001] The invention relates to an anticancer and analgesic traditional Chinese medicine composition, a preparation method of the composition, and an application of the composition in preparing anticancer products and analgesic drugs. (2) Background technology [0002] Morphine is an effective analgesic that can effectively relieve pain in middle and advanced cancer patients, but its side effects, especially the side effects of addiction, make it unfavorable for long-term use. People have been working hard to find alternatives to morphine. Cancer treatment is a project of general concern and key research in the medical field. Western medicine has its limitations. It regards the human body simply as a substance and continuously dissects it into monomers. Therefore, it lacks the concept of systemic adjustment in the treatment of diseases. Moreover, synthetic drugs have obvious toxic and side effects, and are likely to cause drug-induced pain to patients. P...

Claims

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Application Information

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IPC IPC(8): A61P29/00A61P35/00
Inventor 杨亿泓魏伟伟
Owner SHANGHAI ZHONGYAO BIO TECH CO LTD
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