Hepatocurative effect of emblica officinalis on hepatotoxicity related to cytoch rome P-45O

A technology of therapeutic effect and hepatotoxicity, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, non-effective ingredients of polymer compounds, etc., can solve problems such as reversal of clinical parameters

A technology of therapeutic effect and hepatotoxicity, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, non-effective ingredients of polymer compounds, etc., can solve problems such as reversal of clinical parameters

CN1627955AInactive Publication Date: 2005-06-15COUNCIL OF SCI & IND RES
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  • Hepatocurative effect of emblica officinalis on hepatotoxicity related to cytoch rome P-45O
  • Hepatocurative effect of emblica officinalis on hepatotoxicity related to cytoch rome P-45O
  • Hepatocurative effect of emblica officinalis on hepatotoxicity related to cytoch rome P-45O

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Embodiment Construction

[0022] Therefore, the present invention relates to a composition for treating liver diseases and its use in the treatment of drug-induced hepatotoxicity, said composition can counteract CYP 450 bioactivated hepatotoxicity caused by drugs, the composition contains emblica extract substances and optional pharmaceutical additives.

[0023] In one embodiment of the present invention, there is provided a composition for the treatment of liver diseases, the composition can counteract the hepatotoxicity of CYP 450 bioactivation caused by drugs, the composition contains extract of Amla emblica and optional medicinal additive.

[0024] In another embodiment of the present invention, the additive is selected from nutritional substances comprising protein, carbohydrate, sugar, talc, magnesium stearate, cellulose, calcium carbonate, starch-gelatin paste, etc., and / or Pharmaceutically acceptable carrier, excipient, diluent or solvent.

[0025] In yet another embodiment of the invention, ...

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Abstract

The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatoxoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutially acceptable additives and method of treating drug induced hepatotoxicity.

Description

technical field [0001] The present invention relates to a composition for treating liver diseases and its use in treating drug-induced liver toxicity, the composition can resist CYP 450 (cytochrome P-450) bioactivated liver toxicity caused by drugs, the The composition contains emblica extract and optional medicinal additives. Background technique [0002] Liver disease is still a major health hazard in urban and rural areas of the world. Despite scientific advances in our understanding of hepatotoxicity, and clues in this regard from the traditional system of medicine, we do not yet have effective pharmaceutical compositions for the treatment of liver diseases, especially those caused by various drugs. The Indian Council of Medical Research in New Delhi has included liver disease as one of six priority breakthrough areas for multidisciplinary research in its Traditional Medicines Research Programme, Revised Edition. [0003] Liver disease can be divided into acute or chro...

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Application Information

Patent Timeline
15 Jun 2005
Publication
CN1627955A
IPC
A61K9/10; A61K9/12; A61K9/14; A61K9/20; A61K9/48; A61K36/18; A61K36/47; A61K47/02; A61K47/12; A61K47/26; A61K47/38; A61K47/42; A61P1/16; A61P39/02; A61P43/00
CPC
A61K36/47; A61P1/16; A61P39/02; A61P43/00; A61K2300/00
Inventors
拉凯什·卡迈勒·约里; 谢赫·塔萨达克·阿卜杜拉