Norethindrone sustained release formulations and methods associated therewith

A technology of norethisterone and norethisterone acetate, which is applied in the directions of organic chemistry, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as increasing the risk of pregnancy
CN1655794AInactive Publication Date: 2005-08-17WATSON PHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WATSON PHARMA INC
Publication Date
2005-08-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.
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Description

[0001] Priority date

[0002] This application claims the priority of U.S. Provisional Patent Application Serial No. 60 / 383,790 filed on May 30, 2002, which is incorporated herein by reference. Invention field

[0003] The invention relates to a sustained-release transdermal preparation of norethindrone and related methods. Therefore, the present invention covers the fields of pharmaceutical sciences, medicine and other health sciences. Background of the invention

[0004] Female hormones such as estrogen and progesterone have been shown to have numerous medical uses, such as hormone replacement therapy (HRT) and contraception for women. Oral and transdermal dosage forms containing estrogen or progestin are well known, and both are often administered together in a single formulation. Due to the stringency and lifelong nature of HRT and contraception, transdermal formulations are an alternative to immediate-release oral dosage forms. However, because the skin is a strong barrier to...

Claims

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