Peony astragalus polyglucoside composition for treating liver disease and its preparation method

A composition, the technology of peony qi, applied in the field of pharmaceutical composition and its preparation, can solve problems such as shortage, and achieve the effects of easy quality control, improved drug efficacy, and small effective dose

Inactive Publication Date: 2005-10-26
魏伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no ideal safe and effective anti-hepatitis drug clinically, especially the lack of drugs for the treatment of chronic hepatitis and liver fibrosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] One of the preparation methods of preparation medicine:

[0025] 1. Preparation of total glucosides of paeony: Proportionately take white peony herbaceous materials, process them into common Chinese medicine decoction pieces according to Chinese Pharmacopoeia 2000 edition one; %, the weight ratio is Radix Paeoniae Alba: Alcohol=1: 2-15, extract 2-4 times, each extraction time 0.5-5 hour, obtain ethanol extract; Ethanol extract is carried out decompression concentration to no ethanol smell, filter After that, put it on D101, D-3520, NKA, AB-8, XAD-2, XAD-4 or D201 macroporous adsorption resin column; first wash with water to remove impurities, and then use 20%-90% ethanol to elute to obtain ethanol Eluate: collect the ethanol eluate, concentrate under reduced pressure, and dry under reduced pressure to obtain total glucosides of paeony powder.

[0026] 2. Preparation of total astragalus saponins:

[0027] Get Radix Astragali medicinal material in proportion, process it...

Embodiment 1

[0061] Take 80kg of Radix Paeoniae Alba and 20kg of Radix Astragali, crush them into coarse powder, put them into an extraction tank, add 800L of water to boil for 3 times, each time for 1 hour, filter the extract while it is hot, let it cool, and put it on D101 macroporous adsorption resin Column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected the 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain paeoniflorin Composition 1.9 kg.

[0062] It was determined that the total glycosides content in the paeoniflorin polyglycoside composition obtained in the above experiment was 63%, of which total glucosides of paeony accounted for 86%, and total saponins of Astragalus accounted for 14%.

Embodiment 2

[0064] Take 80kg of Radix Paeoniae Alba and 20kg of Radix Astragali, cut into decoction pieces, put them in an extraction tank, add 1000L of 70% ethanol to extract 3 times, each time for 1.5h, filter the extract while it is hot, let it cool, and absorb it on NKA macropores Resin column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain Paeoniae alba Glycoside composition 1.6kg.

[0065] It was determined that the content of total glycosides in the paeoniflorin polyglycoside composition obtained in the above experiment was 76%, of which total glucosides of paeony accounted for 87%, and total saponins of Astragalus accounted for 13%.

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PUM

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Abstract

A Chinese medicine in the form of particle, capsule, tablet, or injection for treating chronic hepatitis, hepatofibrosis and early-phase hepatocirrhosis is prepared from white peony root and astragalus root. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, more specifically a pharmaceutical composition for treating liver diseases and a preparation method thereof. Background technique: [0002] Liver disease has a high incidence rate and is one of the common diseases that seriously endanger people's health. At present, although there are many drugs used to treat liver diseases, most of them belong to the auxiliary status. There is no ideal safe and effective anti-hepatitis drug clinically, especially the lack of drugs for the treatment of chronic hepatitis and liver fibrosis. Invention content: [0003] The present invention aims to avoid the shortcomings of the above-mentioned prior art, and provides a paeoniflorin composition for treating liver diseases with high active ingredient content, stable quality and definite curative effect and a preparation method thereof. [0004] The technical scheme that the present...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 魏伟宋力桂双英
Owner 魏伟
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