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Parallel column scanning spectrum type surface plasma resonant imaging method and apparatus

A surface plasmon and row-column scanning technology, applied in the field of refractive index imaging, can solve problems such as inadaptability and slow measurement speed, and achieve the effects of large information throughput, high efficiency, and high refractive index resolution

Inactive Publication Date: 2006-03-01
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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Problems solved by technology

This method can quantitatively describe the refractive index distribution of the measured surface, but this method uses point-by-point scanning measurement, which makes the measurement speed very slow and cannot meet the requirements of high-throughput measurement such as protein arrays.

Method used

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  • Parallel column scanning spectrum type surface plasma resonant imaging method and apparatus
  • Parallel column scanning spectrum type surface plasma resonant imaging method and apparatus
  • Parallel column scanning spectrum type surface plasma resonant imaging method and apparatus

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with the accompanying drawings.

[0022] refer to figure 1 , the parallel-parallel scanning spectral surface plasmon resonance imaging device mainly includes an SPR generating device 4 , an incident arm, a reflection arm and a computer 7 for image processing. The SPR generating device 4 includes a prism and a gold film arranged on the prism slope, and the outer surface of the gold film is a measured plane, which is used for attaching the side object; the SPR generating device 4 is able to translate, and it is installed on On a controllable mobile platform 43, the controllable mobile platform can be realized by manual or automatic control. The incident arm is arranged on one side of the SPR generating device 4, and it includes a broadband light source 1, a polarizing device 2 and an optical system 3 containing a cylindrical mirror that generates a thin linear beam in turn, and the thin linear beam ente...

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Abstract

Its method includes the following steps: changing the beam emitted by broadband light source into a hairline beam; making said hairline beam be irradiated on SPR generation device; after the beam outcome from said device is dispersed, utilizing two-dimensional photoelectric detection device to make detection and obtain SPR spectrum information in a lighted line-type region of tested plane; translating said device and using said hairline beam to scan the whole tested plane to obtain SPR spectrum information of all the columns of whole tested plane; utilizing computer to make operation and processing to obtain refractive index information of whole tested plane in said device so as to form a two-dimensional image. Said method can be used for detecting various biological chips.

Description

Technical field: [0001] The invention belongs to the technical field of optical imaging detection, in particular to a refractive index imaging method and device based on column-scanning spectral surface plasmon resonance (SPR) technology. Background technique: [0002] The surface plasmon resonance (SPR) sensing method has been widely used in the fields of biology and chemistry because of its high sensitivity and label-free characteristics. There have been reports on the use of point-measurement SPR sensing methods to study protein reactions, chemical reactions, etc. (Anal. Chem. 70 (1998) 2019-2024). However, with the widespread application of biological arrays (i.e., biochips) such as gene arrays and protein arrays, the refractive index sensing of points cannot meet the needs of research. . The traditional imaging method using SPR (Nature 332 1988.615-616.), that is, SPM (surface plasmon microscopy), fixes the frequency and incident angle of the incident parallel light b...

Claims

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Application Information

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IPC IPC(8): G01N21/41G01N21/84G06K9/00G06F19/00
Inventor 刘乐何永红郭继华马辉
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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