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Method and equipment for transcranial cerebral blood flow high-resolution imaging

An imaging method and cerebral blood flow technology, applied in the field of cerebral blood flow detection, to achieve the effect of no damage spatial resolution and high spatial resolution

Inactive Publication Date: 2006-06-28
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0003] The object of the present invention is to provide a high-resolution imaging method of transcranial cerebral blood flow, which solves the problem that the existing high-resolution cerebral blood flow imaging method needs to perform craniotomy or thinning of the skull on the experimental subject, and realizes cerebral blood flow imaging. High-resolution transcranial non-invasive imaging of flow two-dimensional distribution; the invention also provides a device for realizing the method

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  • Method and equipment for transcranial cerebral blood flow high-resolution imaging
  • Method and equipment for transcranial cerebral blood flow high-resolution imaging
  • Method and equipment for transcranial cerebral blood flow high-resolution imaging

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[0023] The reconstruction of cerebral blood flow distribution images needs to use multiple frames of laser speckle images collected at each time point where cerebral blood flow needs to be measured, and analyze the time-domain statistical characteristics of laser speckle images for the collected laser speckle image sequences, and calculate Time statistic of the light intensity (i.e. image gray level) on each pixel in the laser speckle image changes with time, and this statistic reflects the blood flow velocity at the cortex corresponding to the pixel; thus traversing all the pixels in the image Pixels, high-resolution two-dimensional cerebral blood flow distribution images can be obtained.

[0024] Specifically, the steps of the inventive method are:

[0025] (1) Irradiate a collimated laser beam with a wavelength in the range of 700-950nm onto the object to be measured;

[0026] (2) Continuously collect N frames of laser speckle images reflected by the measured object with t...

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Abstract

A high-definition imaging method for the craniocerebral blood flow includes such steps as irradiating the near infrared collimated laser beam onto an object to be tested, continuously taking several frames of reflected laser speckle image at intervals, calculating the time contrast of light intensity variation with time for each pixel, calculating the speed of its cerebral blood flow, and using it as grayscale to configure the 2D speed distribution chart of cerebral blood flow. Its apparatus is composed of laser device, two polarizers, bench, photoelectric imaging system and computer.

Description

technical field [0001] The invention belongs to the detection technology of cerebral blood flow, specifically a high-resolution imaging method and device of transcranial cerebral blood flow, which is especially suitable for studying the distribution of local blood flow in cerebral cortex and the morphology of cerebral blood vessels under physiological and pathological conditions. Background technique [0002] Obtaining high-resolution local two-dimensional blood flow distribution information in the cerebral cortex is useful for the study of brain neuro-vascular coupling and regulation under physiological and disease states, brain functional imaging, evaluation of the effects of drugs on cerebral blood vessels and microcirculation, and cerebral ischemia, The diagnosis and pathological research of serious brain diseases such as cerebral hemorrhage are of great significance. However, most of the traditional cerebral blood flow detection methods do not have imaging capabilities,...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026A61B6/00G06F19/00G06T1/00
Inventor 李鹏程曾绍群骆清铭
Owner HUAZHONG UNIV OF SCI & TECH
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