Medicinal composition for treating B cell lymph tumour

A composition and a technology for lymphoma, which are applied in the field of pharmaceutical compositions for treating cancer, can solve the problems of expensive treatment costs and drug resistance of patients, and achieve the effects of reducing costs and improving curative effects.

Inactive Publication Date: 2006-08-30
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment cost of patients is expensive, and some patients develop drug resistance in the early stage of treatment or when the disease relapses

Method used

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  • Medicinal composition for treating B cell lymph tumour
  • Medicinal composition for treating B cell lymph tumour
  • Medicinal composition for treating B cell lymph tumour

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of a pharmaceutical composition for treating B-cell lymphoma

[0029] The invention relates to a pharmaceutical composition for treating B-cell lymphoma, which is prepared by mixing rituximab and SAHA according to a certain concentration ratio. The dosage of rituximab was 20 μg / ml, and the dosage of SAHA was 2.5 μM.

Embodiment 2

[0031] Preparation of a pharmaceutical composition for treating B-cell lymphoma

[0032] The invention relates to a pharmaceutical composition for treating B-cell lymphoma, which is prepared by mixing rituximab and SAHA according to a certain concentration ratio. The dosage of rituximab was 1 μg / ml, and the dosage of SAHA was 10 μM.

Embodiment 3

[0034] Preparation of a pharmaceutical composition for treating B-cell lymphoma

[0035] The invention relates to a pharmaceutical composition for treating B-cell lymphoma, which is prepared by mixing rituximab and SAHA according to a certain concentration ratio. The dosage of rituximab was 100 μg / ml, and the dosage of SAHA was 1 μM.

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Abstract

A composite medicine for treating B-cell leucoma is prepared from rituximab and suberoylanilide hydroxamic acid (SAHA). Its advantages are obvious synergistic effect, high curative effect and low cost.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cancer, in particular to a pharmaceutical composition for treating B-cell lymphoma. Background technique [0002] Lymphoma is a kind of malignant tumor originating from lymphoid tissue. In recent years, the worldwide incidence rate has almost doubled, seriously endangering human health. B-cell lymphoma is the most common type of lymphoma, accounting for about 50-60% of lymphomas. Except for early-stage, localized, and low-grade B-cell lymphoma, which can be treated with radiotherapy alone, the current main treatment method is still combined chemotherapy. Combined chemotherapy can make about 50-60% of patients achieve disease remission, and 20-30% of patients achieve long-term survival, but most patients are ineffective or relapse rapidly after treatment, the disease progresses rapidly, and the prognosis is poor. More importantly, the side effects of chemotherapy are large, and patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P35/00A61K31/15
Inventor 陈竺陈赛娟赵维莅王兰刘元华阎金松
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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