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Azlocillin/clavulanic acid antibacterial composition

A technology of clavulanic acid and azlocillin, applied in the direction of antibacterial drugs, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc. Effect

Inactive Publication Date: 2006-09-27
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although each specific drug in the semi-synthetic penicillin antibacterial drugs can be said to have a broad antibacterial spectrum and strong antibacterial effect, in fact it can only be highly active against a certain type, or certain types of bacteria, while it is only active against other bacteria. general antimicrobial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Under aseptic and clean conditions, 10 kilograms of azlocillin sodium (calculated by azlocillin) and 1 kilogram of potassium clavulanate (calculated by active acid) are mixed, and the powder of the present invention is prepared according to the powder injection preparation process procedure injection.

Embodiment 2

[0019] Embodiment 2: Under aseptic and clean conditions, 10 kilograms of azlocillin sodium (calculated by azlocillin) and 5 kilograms of potassium clavulanate (calculated by active acid) are mixed, and the powder of the present invention is prepared according to the powder injection preparation process procedure injection.

Embodiment 3

[0020] Embodiment 3: Under aseptic and clean conditions, 8 kilograms of azlocillin sodium (calculated by azlocillin) and 1 kilogram of potassium clavulanate (calculated by active acid) are mixed, and the powder of the present invention is prepared according to the powder injection preparation process procedure injection.

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PUM

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Abstract

The present invention belongs to the field of medicine technology, relates to compound antibiotic medicine capable of inhibiting bacteria produced beta-lactamase, and is especially compound antibiotic azlocillin / clavulanate medicine. The compound antibiotic azlocillin / clavulanate medicine is compounded with azlocillin and clavulanate in the weight ratio of 1-20 as the active components. Azlocillin and clavulanate in the compound medicine has obvious synergistic effect, and the compound medicine can inhibit the activity of beta-lactamase and protect azlocillin against the destruction of bacteria produced beta-lactamase, is favorable to the antibiotic effect of azlocillin in strengthen antibiotic activity, widened antibiotic spectrum, less resistance and raised clinical treating effect.

Description

technical field [0001] The invention relates to an antibiotic compound drug for inhibiting β-lactamase produced by bacteria, and belongs to the technical field of drugs. Background technique [0002] Semi-synthetic penicillin antibiotics have been widely used clinically, and have achieved therapeutic effects that are difficult to achieve with traditional antibiotics. However, due to the long-term and extensive clinical use of antibiotics, and even the abuse of antibiotics, bacteria have become increasingly resistant to antibiotics. Azlocillin is a semi-synthetic penicillin antibiotic commonly used in clinical practice. Citrobacter, Serratia, Acinetobacter and penicillin-sensitive Gram-positive cocci all have bacteriostatic effect, and large doses have bactericidal effect; G-bacteria include Pseudomonas aeruginosa, Escherichia coli, Enterobacter gram Rabsiella, Serratia, Proteus, etc. also have a good antibacterial effect. It also has a good antibacterial effect on most an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61P31/04A61K31/424
Inventor 赵玉山何茂群任正伟李广王子伟段祥永
Owner REYOUNG PHARMA