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Gene composition for screening pancreatic catheter gland cancer and its application

A technique of pancreatic ductal adenocarcinoma and gene, which is applied in the field of gene combination and screening of pancreatic ductal adenocarcinoma, can solve the problem of no ideal pancreatic cancer tumor markers, and achieve high prediction accuracy, high sensitivity and specificity

Inactive Publication Date: 2012-07-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no ideal pancreatic cancer tumor marker from blood. Finding better tumor markers in the blood of pancreatic cancer patients has high clinical application value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. According to the Affymetrix gene expression profiling chip operation guide, use AFFYMETRIXHUMAN GENOME U133 PLUS 2.0 ARRAY to detect the expression of this group of genes in the PBMC of 5 pancreatic cancer and 5 normal people, and obtain the signal value of gene expression (see Table 1) .

[0017] Table 1

[0018] sample

L48784

X83300

AI620827

AI494291

NM_02097

BF433657

J02959

BC022313

NM_000904

NM_004994

T1

T2

T3

T4

T5

N1

N2

N3

N4

N5

6615.2

11386.6

5944.1

5007.4

6973.1

21113.1

10817.5

13886.1

16847.6

17733 3

340.3

658.7

496.2

453.5

703.5

773

782.5

1022.6

1836.3

1396.6

657.9

730.5

1018.2

890.8

1478.2

2161.5

1772.8

1846.8

2274.3

1949.2

708.1

553.5

...

Embodiment 2-51

[0031] K-fold cross-validation is to divide the samples into a test group and a training group, and build a model through the training group samples to speculate on the test group samples. After repeating k times, calculate the average correct rate of k guessed correct rates to get the final correct rate of the model.

[0032] According to all 25 possible permutations and combinations, this experiment divides the samples into 25 groups by 25 groups of cross-validation, each group has 8 samples (4 cancer and 4 normal) as training samples, and the remaining 2 as test samples . Use the training group samples to establish screening criteria (see Table 2-51) to predict the correct rate of whether the test group samples are cancer.

[0033] The meanings of various abbreviations in Table 2-51:

[0034] Difference 1 = signal value of tested sample - median,

[0035] T mean: the average value of the signal value of the tumor sample,

[0036] N mean: the average value of the normal ...

Embodiment 2

[0041] The operation refers to Example 1, and the results are shown in Table 2.

[0042] Table 2. Cross Validation 1-1

[0043] sample

[0044]

[0045] In Table 2: The compliance rate is 10 / 10. It is presumed that the tested sample is pancreatic cancer.

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Abstract

The present invention provides a group of assortment of genes, including 10 genes; L48784, X83300, A1620827, A1494291, NM-020970, BF433657, JO2959, BC 022313, NM-000904 and NM-004994, for screening ductal adenocarcinoma of pancreas. Said invention can utilize detection of said group of genes of human peripheral blood mononuclear cell to screen out patient with pancreatic cancer from health human group.

Description

[0001] Technology [0002] The invention belongs to biological technology, and mainly relates to a group of gene combinations for screening pancreatic ductal adenocarcinoma. Background technique [0003] Pancreatic cancer is a malignant tumor with poor prognosis. The overall median survival time was less than 6 months. The 5-year survival rate is only 0.4-5%. Surgical resection of tumor can improve the survival period. The median survival time of patients with surgical resection of tumor can reach 11-20 months, and the 5-year survival rate can reach 7-25%. However, patients with pancreatic cancer lack early clinical manifestations. Most of the patients are in the late stage when they go to see a doctor. [0004] Due to the high surgical risk of pancreatic cancer resection and biopsy, it is not easy to obtain clinical specimens of pancreatic cancer, which prevents most pancreatic cancer patients from receiving a clear and timely diagnosis, thus delaying the treatment of pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68
Inventor 吴育连燕海潮
Owner ZHEJIANG UNIV
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