Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

Abstract

The present invention provides aminopyrimidine compounds of formula (I) and their salts, wherein R1, R2, R3, R4, R5, R6, Q, Z, L, m, n are defined as the description, the methods for preparation thereof, the uses thereof and the pharmaceutical compositions comprising the effective amount of compounds of formula (I). The compounds of formula (I) and their salts can be used as protein kinase inhibitors.

Description

technical field The present invention relates to an aminopyrimidine compound of general formula (I) and its salt, a preparation method thereof, and the application of the compound alone or in combination with other drugs in the treatment of cell proliferative diseases (such as cancer). Background technique In more than 95% of chronic myelogenous leukemia patients, due to chromosomal translocation, BCR-ABL fusion protein is produced, resulting in high expression of ABL tyrosine kinase activity. Drug indications. Human chronic myelogenous leukemia K562 cells express Bcr-Abl protein, so the present invention is a common cell model for researching drugs targeting BCR-ABL. In the prior art, chronic myelogenous leukemia is treated with, for example, recombinant interferon α-2a, which has broad-spectrum antiviral, antitumor and immunomodulatory functions. Interferon binds to cell surface receptors, induces cells to produce a variety of antiviral proteins, inhibits virus reproduc...

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