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Use of telmisartan for the prevention and treatment of vascular headache

a technology of telmisartan and vascular headache, which is applied in the field of use, can solve the problems of compound interaction with the renin-angiotensin system, migraine pathophysiology is still unknown, and the treatment is not easy, and achieves the effect of high efficacy and favorable prophylaxis of vascular headaches

Inactive Publication Date: 2005-03-24
BOEHRINGER INGELHEIM INT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

It has been found that a particular member of the group of AT II type I receptor antagonists, namely telmisartan, provides unexpected advantages in the prophylaxis of vascular headaches, especially migraine, to a subject in need of such treatment, with high efficacy, independently of its known blood pressure reducing activity. INN Telmisartan, {4′-[2-n-propyl-4-methyl-6-(1-methyl benzimidazol-2-yl)benzimidazol-1-ylmethyl]biphenyl-2-carb

Problems solved by technology

Although considerable progress has been made, the pathophysiology of migraine is still not understood.
The latter may also be quite disturbing and require treatment although its duration is relatively brief.
These compounds are known to interfere with the renin-angiotensin system (RAS) and have been used so long to treat common cardiovascular diseases, particularly arterial hypertension and congestive heart failure.

Method used

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  • Use of telmisartan for the prevention and treatment of vascular headache
  • Use of telmisartan for the prevention and treatment of vascular headache

Examples

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Embodiment Construction

Within the present invention the term “telmisartan” includes {4′-[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid} in its neutral form as carboxylic acid as disclosed in EP 0 502 314 B1 and U.S. Pat. No. 5,591,762, or in one of its polymorphic forms as disclosed in WO 00 / 43370, U.S. Pat. No. 6,358,986 and U.S. Pat. No. 6,410,742, or in the form of a pharmaceutically acceptable salt or the solvate, hydrate, or hemihydrate thereof as disclosed in WO 03 / 037876, including but not limited to the sodium, potassium or ammonium salt. When a salt of telmisartan is used, the sodium salt is preferred. In addition, according to the present invention the term “telmisartan” includes any prodrug, e.g. an ester, which is hydrolyzed in vivo to the pharmacologically active compound.

Within the present invention, the term “vascular headaches” includes any kind of vascular headaches, like migraine, cluster headache, post-traumatic headache, etc. not...

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Abstract

The present invention relates to a method for the prophylaxis of vascular headaches which do not originate from hypertension, especially migraine, the method comprising administration of telmisartan to a subject in need of such a treatment. The present invention relates also to a method for the prophylaxis of vascular headaches, comprising the co-administration of telmisartan in combination with other drugs suitable for migraine prophylaxis and / or acute treatment of migraine.

Description

FIELD OF THE INVENTION The present invention relates to a method for the prophylaxis of vascular headaches which do not originate from hypertension, especially migraine, the method comprising administration of {4′-[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid} (telmisartan) to a subject in need of such a treatment. The present invention relates also to a method for the prophylaxis of vascular headaches, comprising the co-administration of telmisartan in combination with other drugs suitable for migraine prophylaxis and / or acute treatment of migraine. The invention further relates to suitable pharmaceutical compositions comprising telmisartan and at least one other drug used in migraine prophylaxis, as a combined preparation for simultaneous, separate or sequential use in the prophylaxis of said disease. The invention relates further to the use of telmisartan, optionally in combination with said other antimigraine drugs for the...

Claims

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Application Information

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IPC IPC(8): A61K31/4184A61K31/5513A61K38/22A61K45/06A61P25/06
CPCA61K31/4184A61K31/5513A61K38/225A61K45/06A61K2300/00A61P25/06
Inventor DAVIDAI, GIORA
Owner BOEHRINGER INGELHEIM INT GMBH
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