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Use of huperzine for disorders

a technology of acetylcholinesterase and huperzine, which is applied in the direction of biocide, synthetic polymeric active ingredients, drug compositions, etc., can solve the problems of dose and administration mode of the compound being different for ad, and achieve the effects of reducing the risk of side effects

Inactive Publication Date: 2006-11-23
PRESIDENT & FELLOWS OF HARVARD COLLEGE
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes the use of a compound called huperzine to treat pain and seizures. This compound has been found to reduce the severity and duration of pain and seizures in humans. It works by blocking a specific receptor in the body that is involved in pain and seizures. The compound can be administered in different ways, such as through a pill or through a patch. It is effective in treating pain and seizures, with minimal side effects. The dose and duration of treatment can vary depending on the individual and the type of pain or seizure being treated.

Problems solved by technology

Such patients are also treated using a huperzine compound; however, the dose and mode of administration of the compound is different for AD compared to pain.

Method used

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  • Use of huperzine for disorders
  • Use of huperzine for disorders
  • Use of huperzine for disorders

Examples

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Embodiment Construction

[0049] Pain is diagnosed and evaluated in a number of standard methods such as the McGill Questionnaire (Melzack, R., 1975, Pain 1:277-299; Wright et al, 2001, Eur. J. Pain 5:279-284). Children as young as two years old can report pain, and standards for evaluating pain in children include evaluation of facial expression (Bieri et al., 1990, Pain 41: 139-150; Kuttner et al, 1989, Can. J. Behav. Sci. 21: 198-209). A medically desirable result of a reduction in pain for joint disease such as osteoarthritis is measured, e.g., using a visual analog pain scale described in Peyron et al., 1993, J. Rheumatol. 20 (suppl.39):10-15).

[0050] Huperzine compounds are used to relieve both acute and chronic pain. Subjects to be treated are diagnosed with pain as described above or report / describe pain perception. Administration for pain relief is distinguished from patients or mode of administration for treatment of AD. For example, candidate patients for treatment are selected based on exclusion ...

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Abstract

Methods and compositions containing huperzine are used to alleviate pain and for the prevention and / or treatment of seizures and epilepsy. The invention is also directed to methods and compositions for using huperzine for the prevention and / or treatment of neuropathic pain and orthostatic hypotension.

Description

RELATED APPLICATIONS [0001] This application claims priority to provisional patent applications U.S. Ser. No. 60 / 683,745, filed May 23, 2005, and U.S. Ser. No. 60 / 756,141, filed Jan. 4, 2006, respectively. The contents of each provisional application are hereby incorporated by reference.BACKGROUND OF THE INVENTION [0002] The technical field of this invention relates to using NMDA antagonists and acetylcholinesterase (AChE) inhibitors in neurologic syndromes and disorders. [0003] Pain management remains a ubiquitous clinical problem. In addition to injury, nearly every disease or pathological condition from arthritis to cancer to HIV infection and diabetes has a major pain component. Pain management for some conditions such as nerve injuries and chronic inflammatory disease has been poor. While a number of drugs exist to alleviate pain, the use of many of them is limited by safety issues and side effects. SUMMARY OF THE INVENTION [0004] Huperzine has been found to be useful to reduce...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/4745A61K31/473
CPCA61K9/0019A61K9/0024A61K31/74A61K31/473A61K31/4745A61K31/215A61P19/02A61P25/00A61P25/02A61P25/08A61P29/00
Inventor SCHACHTER, STEVEN C.
Owner PRESIDENT & FELLOWS OF HARVARD COLLEGE
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