21 results about "Orthostatic BP" patented technology

The invention discloses a spinal post-operation erect hypotension volume management method and system and a terminal. The method comprises the steps that individual physiological features, preoperative evaluation data, intraoperative monitoring data and post-operation monitoring data of a target patient are obtained; constructing an artificial intelligence model, and training, verifying and testing the artificial intelligence model to obtain a target evaluation model; inputting the preoperative evaluation data, the intraoperative monitoring data and the postoperative monitoring data into a target evaluation model for evaluation to obtain a risk probability; according to the individual physiological features, the preoperative evaluation data, the intraoperative monitoring data and the risk probability, making a personalized fluid infusion management scheme for the target patient; according to the fluid infusion management scheme, fluid infusion is conducted on the target patient, the patient condition is monitored in real time, and early warning information is sent out to take first-aid measures. Multi-source data are fused, the occurrence risk of the erect hypotension of the patient is evaluated and managed in real time, fluid infusion management is enhanced, and fluid infusion efficiency is improved.

The invention discloses a traditional Chinese medicine preparation for treating multi-system atrophic upright hypotension and a preparation method. The traditional Chinese medicine preparation is prepared from the following raw materials: ginseng, astragalus membranaceus, antler, roasted ephedra, rehmannia, radix ophiopogonis, radix paeoniae alba, rhizoma cimicifugae and pericarpium citri reticulatae viride. The traditional Chinese medicine composition has the effects of tonifying qi, warming yang, nourishing blood and yin and ascending and descending qi function, and emphasizes the effect of ascending and descending qi function in blood pressure regulation by perfecting the etiology and pathogenesis of MSA erect hypotension; the pathogenesis of the MSA erect hypotension is mainly viscera asthenia and qi and blood ascending and descending disorder, so that the treatment effect is achieved by ascending yang and nourishing yin.

The present invention provides a method of treating Parkinson's disease by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency. The present invention, by irradiating light of a specific wavelength such as violet light to a living body, carries out treatment and / or prophylaxis of Parkinson's disease by improving or suppressing at least one symptom selected from a group of symptoms consisting of cognitive memory disorder, working memory disorder, dysphoria, anxiety, apathy, psychological symptoms (hallucination, visual hallucination, and auditory hallucination), impulse control disorder, orthostatic hypotension, urinary disorder, sexual dysfunction, digestive symptoms (drooling, swallowing, nausea, constipation), sleep disorder, pain, weight loss, olfactory abnormality, fatigue, and diaphoresis.

The invention discloses an automatic pressurizing and pressure measuring intelligent bellyband device in the field of intelligent wearable equipment, which comprises a bellyband body, the bellyband body is provided with a band length regulator and a first battery, the inner side of the bellyband body is fixedly connected with a skin-friendly layer, and a pressurizing airbag assembly, a pressure sensor, a motion sensing assembly and a controller are arranged between the bellyband body and the skin-friendly layer; the controller is used for predicting the risk of postural hypotension in combination with the motion state data of the wearer, and controlling the pressurizing air bag assembly to pressurize the abdominal cavity of the wearer based on the data of the pressure sensor when the postural hypotension is predicted; the pressurizing air bag assembly is used for extruding the abdominal cavity of the wearer to enable blood to enter the thoracic cavity when the postural hypotension is predicted to occur. The device is simple and effective, the physical condition of a wearer is detected through the motion sensing assembly and the blood pressure detection assembly, the controller predicts the postural hypotension and controls the pressurization air bag assembly to inflate to pressurize the abdominal cavity, and the probability of occurrence of the postural hypotension and the symptom severity are reduced.

To provide terlipressin compositions and their methods of use.SOLUTION: Disclosed herein are methods for treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof. In some embodiments, terlipressin exhibits improved bioavailability (BA) in a composition or oral dosage form described herein relative to terlipressin configured in another formulation or dosage form.SELECTED DRAWING: None

The present invention relates to oral therapy of a subject suffering from disease e.g. polycystic disease e.g. polycystic kidney disease or polycystic liver disease or PCOS or hypotension especially neurogenic orthostatic hypotension and postprandial hypotension, or intractable diarrhea or neuroendocrine tumors or carcinoid syndrome. The method of treatment comprises oral administration to the subject of a therapeutically effective amount of an oral somatostatin receptor ligand (SRL) e.g. oral octreotide. Combination therapy of oral SRLs with other drugs is also envisaged, e.g. octreotide in combination with a therapeutically effective amount of a second therapeutic agent and optionally in combination with a therapeutically effective amount of a third therapeutic agent.

Embodiments of this disclosure provide an orthostatic hypotension monitoring method. The method includes displaying a blood pressure monitoring interface having operation instruction information that instructs an operator to confirm a posture state of a monitored object; measuring physiological parameter data of the monitored object, in response to the state confirmation instruction of the operator, and acquiring an orthostatic hypotension monitoring result based on the physiological parameter data automatically. This method can provide the operator with an auxiliary interface according with the orthostatic hypotension assessment process, and guide the operator to complete the orthostatic hypotension assessment according to the standardized assessment criteria. Accordingly, the operation process is simple and convenient, and the accuracy of the monitoring results is relatively high. In additional, an orthostatic hypotension monitoring apparatus is further provided in this disclosure.

This invention relates to the field of medical devices, specifically to a puncture device for neurological nursing, comprising a frame, a bed board, and a limiting mechanism. The bed board is vertically and horizontally positioned below the limiting mechanism. The limiting mechanism includes a head and back limiting unit, a hip and leg limiting unit, and a slide rail unit. The slide rail unit includes two slide rails connected to the frame, with the width of the bed board and the length of the guide rails being less than the distance between the two slide rails. The head and back limiting unit includes a head and back support frame slidably connected to and fixed to the slide rails, a head and back limiting block rotatably connected to the head and back support frame, and an upper body support block perpendicularly and fixedly connected to the head and back limiting block. The hip and leg limiting unit includes a hip and leg support frame slidably connected to and fixed to the slide rails, a hip and leg limiting block rotatably connected to the hip and leg support frame, and a lower body support block perpendicularly and fixedly connected to the hip and leg limiting block. This technical solution helps to address safety issues arising from patients' easily changing lying positions, lumbar twisting during position adjustments, and orthostatic hypotension.

The disclosed system, and related devices and methods, relate to the automatic compression of the body parts of a patient to treat and prevent symptoms of orthostatic hypotension. The system, devices, and methods can monitor the position, temperature, and / or blood flow of the patient to only employ compression when an orthostatic hypotension event occurs.

This invention discloses a method and device for dynamic blood pressure assessment based on postural transition phases. It identifies postural transitions from postural sensor data and delineates the boundaries of the preparation, transition, and stabilization phases based on individualized reflex delay compensation. It constructs an individualized blood pressure baseline curve based on phased sampling and establishes a phased reference benchmark. It detects a continuous downward trend in the blood pressure deviation sequence and applies individualized rate constraints to form a dynamic trajectory. It removes physiological periodic components using an adaptive rhythm template and determines abnormal fluctuation ranges and completes phased risk assessment based on a joint score of non-rhythmic fluctuation amplitude and duration. It integrates the risk assessment results with the individual baseline level for adaptive weighting based on postural orientation, determines differentiated warning thresholds, and outputs blood pressure change assessment results. This achieves individualized and phased-differentiated accurate assessment of blood pressure abnormalities induced by postural transitions, improving the accuracy and adaptability of orthostatic hypotension risk assessment.

Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.

The present invention discloses a human body detection first aid device for orthostatic hypotension, the first aid device comprises a shell, in which a blood pressure measurement module, a battery compartment, a posture measurement module, a fixing module, a cardiac pacing and data transmission module are arranged in sequence from back to front, and a battery compartment is arranged at the front end of the blood pressure measurement module, a posture measurement module is arranged at the front end of the battery compartment, a fixing module is arranged at the front end of the posture measurement module, and a cardiac pacing and data transmission module is arranged at the front end of the fixing module; the present invention can implant a miniature medical device through minimally invasive intervention, without incision scars, and does not affect the appearance, and can dynamically monitor the blood pressure, heart rate and body position changes of patients with orthostatic hypotension in real time, and adjust according to the characteristics of physiological changes, so that the patient's lifestyle is not affected and the compliance is good, and at the same time, it has a wireless data transmission function for analysis and reading by clinical doctors.

The object of the present invention is to provide a deep brain stimulation system for treating orthostatic hypotension, comprising: a data acquisition module for collecting physiological state information of a patient, and a data fusion module implanted in the subcutaneous region of the pectoralis major muscle for receiving multi-source physiological data output by the data acquisition module, integrating and filtering noise thereof to generate comprehensive physiological state information of the patient (S t ={BP t ,HR t ,ECG t ,Pos t}); a deep brain stimulation module for precisely stimulating a target brain region to enhance sympathetic nerve output; a response module integrated in the data fusion module for analyzing the physiological state information S t and future physiological state prediction value S t+1 , dynamically adjusting the voltage, frequency and pulse width of the deep brain stimulation module, and real-time optimizing the adjustment strategy according to the physiological feedback data of the patient; a deep brain stimulation system providing real-time blood pressure monitoring, posture sensing and intelligent reaction mechanism.

The present invention provides a method of treating Parkinson's disease by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency. The present invention, by irradiating light of a specific wavelength such as violet light to a living body, carries out treatment and / or prophylaxis of Parkinson's disease by improving or suppressing at least one symptom selected from a group of symptoms consisting of cognitive memory disorder, working memory disorder, dysphoria, anxiety, apathy, psychological symptoms (hallucination, visual hallucination, and auditory hallucination), impulse control disorder, orthostatic hypotension, urinary disorder, sexual dysfunction, digestive symptoms (drooling, swallowing, nausea, constipation), sleep disorder, pain, weight loss, olfactory abnormality, fatigue, and diaphoresis.

Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.

To provide a sustained release Midodrine Hydrochloride composition and a method for using the same.SOLUTION: The present disclosure provides a pharmaceutical composition comprising midodrine, a pharmaceutically acceptable salt thereof, desglymidodrine or a pharmaceutically acceptable salt thereof, administrable to a human subject in need thereof. The present disclosure also provides a pharmaceutical composition for treating orthostatic hypotension that can be administered once or twice daily.SELECTED DRAWING: Figure 1

The present application relates to a kind of animal model of dysregulation of blood pressure multiple system atrophy and its construction method, belong to biotechnology field.The present application provides a kind of construction method of dysregulation of blood pressure multiple system atrophy animal model, the construction method includes: experimental animal target brain area is injected with the recombinant adeno-associated virus of oligodendrocyte specific expression alpha-synuclein, obtains multiple system atrophy animal model;The multiple system atrophy modeling target brain area is the ventral area of medulla oblongata head end.The research confirms, the animal model obtained using the construction method can be copied the performance of orthostatic hypotension in multiple system atrophy, and has the typical pathological characteristics and behavior characteristics of multiple system atrophy.Therefore, the construction method and the animal model obtained using the construction method have wide application prospect in the research of multiple system atrophy and the screening of related therapeutic drugs.

The invention discloses a wearable sensory prompter capable of recognizing body position changes, and relates to the field of medical nursing, the prompter comprises a wearable waistband, a buckle head and a sensory prompter loading box, a cable positioning assembly is provided with a plurality of groups of clamping notches, and cables are classified, stably positioned and prevented from falling off and winding through a rubber limiting convex block and a reset spring; the height, the angle and the spacing of the three control assemblies can be flexibly adjusted to adapt to different cable arrangements and equipment models. The loading box is slidably connected with the waistband through the U-shaped buckle, and the buckle head facilitates quick wearing and dismounting. The prompter integrates a body position sensing module, a pulse recognition module, a voice broadcasting module and a vibration module, and guides a user to safely complete body position conversion through double prompts of voice and vibration. Potential safety hazards caused by cable scattering are completely eradicated, wearing comfort and equipment stability are improved, operation is easy and convenient, the device is suitable for old users, related falling accidents caused by upright hypotension can be effectively prevented in an auxiliary mode, and practicability is high.

A therapeutic system and method including an implantable stimulation signal generator, a pair of electrodes in electrical communication with the implantable signal generator, the pair of electrodes being configured for placement proximate sympathetic nerves of a patient, and a motion sensor in communication with the implantable stimulation signal generator, wherein upon detection of motion of a patient in excess of a threshold the implantable stimulation signal generator is configured to output a stimulation signal to the electrodes, wherein the stimulation signal is configured to stimulate nerves to causing a blood vessel to contract.

The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating type 2 diabetes with postural hypotension and its application. The traditional Chinese medicine composition is prepared from the following raw materials in effective amounts: raw astragalus, codonopsis, pseudostellaria, angelica, dendrobium, polygonatum, amomum, immature bitter orange, magnolia bark, tuckahoe, tangerine peel, pinellia, calamus and licorice. The traditional Chinese medicine composition has a scientific and rigorous formula and is used for treating type 2 diabetes with postural hypotension, and has the effect of significantly improving the patient's traditional Chinese medicine symptoms, cognitive ability, blood pressure values ​​and changes in different body positions and body position changes, and has obvious clinical treatment effect.