UVA (> 360-400) and UVB (300-325) specific sunscreens

a sunscreen and ultraviolet light technology, applied in the field of sunscreens, can solve the problems of less than desirable blocking of ultraviolet light in this wavelength rang

Inactive Publication Date: 2006-11-30
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

While various commercially available UVB blockers adequately filter in this UVB range, those available for blocking UVA are less than desirable for blocking UVA radiation in this wavelength range.

Method used

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  • UVA (> 360-400) and UVB (300-325) specific sunscreens
  • UVA (> 360-400) and UVB (300-325) specific sunscreens
  • UVA (> 360-400) and UVB (300-325) specific sunscreens

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Embodiment Construction

[0023]FIG. 1 depicts an overlay of the wavelength distributions of the noon summer sun, a solar simulator used in the following experiments, and an FS40 brand UV lamp filtered with a Kodacell or WG320 filter, all commercially available. As noted in the Background, present sunscreen philosophy is to filter the UVA wavelengths only up to about 360 nm. However, it can be seen that there is a significant irradiance at wavelengths above this region from natural sun. Accordingly, our solar simulator is also designed to deliver these wavelengths.

[0024]FIGS. 2A and 2B depict photomicrographs of stained human in vivo skin samples from subjects exposed to varying amounts of solar-simulated radiation, the amounts being defined by the resulting MED. The samples are stained for the presence of CJUN protein (FIG. 2A), a signaling compound that forms part of AP-1, and also stained for the presence of NF-κB (FIG. 2B), a transcription factor. Signaling involving each of AP-1 and NF-κB results in th...

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Abstract

UVB radiation of about 300-310 nm wavelength and UVA radiation of about 380-390 nm wavelength, each of which exists in solar light, induces MMPs (matrix metalloproteinases) in human skin that degrade the collagen of the dermal matrix. This degradation contributes to photoaging of human skin, which can be prevented by blocking these wavelengths of solar radiation. In contrast, diseases that result in the overproduction of collagen can be treated by exposing the affected with to radiation having wavelengths in those regions, for these wavelengths not only induce MMPs but also inhibit collagen biosynthesis. For lighter skinned people so affected, the UVA wavelengths are preferred because of the reduced amount of erythema, whereas dark skinned people can be treated with the UVB radiation because they generally do not suffer from erythema.

Description

RELATED APPLICATIONS [0001] This application is a division based on of Ser. No. 09 / 900535, filed Jul. 6, 2001, now U.S. Pat. No. ______, based on provisional application No. 60 / 216244, filed 6 Jul. 2000, the disclosure of which is incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] This invention relates to sunscreens that absorb specific wavelengths that we have found induce destructive enzymes in the skin, and to the use of these specific wavelengths in treating skin conditions. [0004] 2. The State of the Art [0005] With regard to photodamage to skin from the sun, the prevailing view is now that both UVB and UVA radiation should be blocked to prevent damage to the skin. It has been known for some time that UVB, while enabling the skin to produce Vit. D3, nevertheless also produces erythema (sunburn). If the UVB radiation reaches a threshold dose level termed the minimum erythemal dose (MED), then sufficient UVB radiation has been de...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/19A61K8/35A61K8/37A61Q17/04
CPCA61K8/35A61Q17/04A61K8/37
Inventor FISHER, GARY J.VOORHEES, JOHN J.KANG, SEWON
Owner RGT UNIV OF MICHIGAN
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