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Methods for Diagnosing Schizophrenia

a psychiatric condition and polypeptide technology, applied in the field of polypeptide markers for diagnosing psychiatric conditions, can solve the problems of confusing similar clinical symptoms, affecting the life quality of affected persons, and presenting a risk of harm to those affected and others, so as to facilitate the diagnosis of psychiatric conditions, reduce the life quality of affected persons, and improve the effect of blood levels of reelin moieties

Inactive Publication Date: 2008-05-15
FATEMI S HOSSEIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005] The methods and materials of the present invention can be used to facilitate diagnosis of psychiatric conditions. The invention is based, at least in part, on the discovery that blood levels of Reelin moieties are altered in patients afflicted with major depression, bipolar disorder, schizophrenia and autism. These and other psychiatric conditions can decrease the life quality of affected persons and can present a risk of harm to those affected and to others. Complicating matters, psychiatric disorders having different causal elements and different treatment protocols can have confusingly similar clinical symptoms. The disclosed tools and techniques can facilitate the diagnosis of psychiatric conditions and thereby improve therapy decisions and patient outcomes.

Problems solved by technology

These and other psychiatric conditions can decrease the life quality of affected persons and can present a risk of harm to those affected and to others.
Complicating matters, psychiatric disorders having different causal elements and different treatment protocols can have confusingly similar clinical symptoms.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Reelin as a Diagnostic Marker for Major Depression, Schizophrenia and Bipolar Disorder

[0053] This example demonstrates that blood Reelin levels can be used to facilitate the diagnosis of major depression, schizophrenia, and bipolar disorder.

[0054] Patients and Controls. Schizophrenic, bipolar and depressed patients were recruited from Fairview University Medical Center (FUMC), its affiliated clinics, and Community University Health Care Center. All patients were formally diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and were evaluated by using standard rating scales by board certified psychiatrists. Table 1 shows the demographic details of psychiatric patients and normal controls. Healthy age-matched control individuals were recruited from FUMC staff or from the surrounding community. The mean age of the control group was 37±16.4; the mean age of the schizophrenic patients was 40±10.9; the mean age of the bipolar patients...

example 2

Reelin as a Diagnostic Marker for Autism

[0068] This example demonstrates that blood Reelin levels can be used to facilitate diagnosis of autism.

[0069] Patients and Controls. Frozen plasma or serum samples belonging to autistic twins, their siblings and parents previously drawn, either in EDTA containing tubes or clot-activated SST gel tubes (Fisher) following acquisition of parental consent from the Autism Genetic Resource Exchange (AGRE, Philadelphia, Pa.) program were obtained from 13 simplex families in which neither parent was affected with autism. Affected individuals included 12 pairs of identical twins and one set of quadruplets. Affected individuals were identified by AGRE examiners using DSM-IV and autism diagnostic interview (ADI) criteria (see, American Psychiatric Association, 1994, Diagnostic and Statistical Manual of Mental Disorders, Fourth Ed., American Psychiatric Press; and Lord et al., 1994, J. Autism. Dev. Disord., 24:659-685). Affected individuals were scored ...

example 3

Genotyping RELN Gene Exon 6 Alleles in Autistic Families and Controls

[0083] This Example demonstrates that the polymorphisms within the nucleic acid sequences encoding Reelin can be used to facilitate the diagnosis of autism.

[0084] Patients and Controls. An A / G transversion polymorphism was previously described (Persico et al., 2001, Mol Psych., 6:150-9) in the 6th exon of the human RELN gene that generates a restriction site for PvuII. This polymorphism was examined using genomic DNA from 9 subjects with autism, 13 first degree relatives (AGRE consortium) and 5 controls and PCR to amplify a 202 bp fragment containing the polymorphic site.

[0085] Analysis of Polymorphisms Using PCR. The following oligonucleotide primers were used for the PCR amplification: (sense) 5′-ACA GCA TGT TGG CAC TTG TG-3′ (SEQ ID NO:1); and (antisense) 5′-GTG AGG AAT GTT CCT GTA AC-3′ (SEQ ID NO:2). The PCR reaction was modified from that described in Persico et al. and was performed using the following re...

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PUM

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Abstract

The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including major depression, bipolar disorder, schizophrenia and autism.

Description

CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application is a Divisional application of, and claims the benefit of priority under 35 U.S.C. §120 to, U.S. application Ser. No. 10 / 346,910 filed Jan. 16, 2003, which claims priority under 35 U.S.C. §119(e) of U.S. Application No. 60 / 349,846 filed Jan. 16, 2002.TECHNICAL FIELD [0002] This invention relates to the use of polypeptide markers for diagnosing psychiatric conditions. BACKGROUND [0003] Reelin is a glycoprotein that seems to have a role in central nervous system development. Reelin was discovered via studies of “reeler” mice, autosomal recessive mutants that have an ataxic and reeling gait. Reeler mice have numerous central nervous system defects, including cerebellar hypoplasia, abnormal neuronal positioning, aberrant orientation of cell bodies and fibers, inverted cortical lamination, and neuronal ectopia in laminated brain structures (e.g., cerebral and cerebellar cortices and hippocampus). [0004] Neuroanatomical defec...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N33/537G01N33/543G01N33/68
CPCG01N33/6896G01N2800/304G01N2800/302G01N2800/30
Inventor FATEMI, S. HOSSEIN
Owner FATEMI S HOSSEIN
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