Method for fostering bone formation and preservation

bone resorption technology, applied in the field of bone resorption promotion, can solve the problems of prior art methods, methods are not commonly able to be targeted on one or more specific bones, and the rate of bone resorption exceeds the rate of bone formation, so as to achieve rapid bone formation, reduce the length of treatment with a bone anabolic agent, and improve the effect of bone resorption ra

US20080183134A1Inactive Publication Date: 2008-07-31UNIGENE LABORATORIES +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2008-07-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of application Ser. No. 11 / 267,987 filed Nov. 7, 2005, which is a continuation-in-part of application Ser. No. 11 / 128,095 filed May 11, 2005, which, in turn, is based on and claims the priority of Provisional Application No. 60 / 571,200 which was filed May 14, 2004, the contents of which are specifically incorporated hereinSTATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] The invention disclosed herein was made with Government support under NIH Grant No. DE 12110 from the National Institutes of Health. Accordingly, the government has certain rights in this invention.FIELD OF THE INVENTION

[0003] The present invention relates generally to a method for fostering bone formation in a subject. More particularly the invention concerns a method for inducing rapid bone formation and then preserving the bone thus produced, e.g., by minimizing its resorption. The invention permits specific targeting ...

Examples

Embodiment Construction

[0040]In a first embodiment the invention provides a method of inducing new bone formation in a subject in need of such inducement. The method comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The above steps may be performed in any order, but are to be carried out in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity at least partially overlap.

[0041]Inducement of bone growth may include, for example, generating new or additional bone at locations where such bone growth is not presently taking place and / or stimulating the growth (i.e., increasing the rapidity thereof) of bone which is already in the process of formation. Without being bound in any way by theory, applicants believe that the inducement of bone growth takes place due to the combined effects of (1) a me...