Novel TNF receptor death domain ligand proteins and inhibitors of ligand binding

a technology of tnf receptor and ligand protein, which is applied in the direction of peptide/protein ingredients, dna/rna fragmentation, fungi, etc., can solve the problems that the ligands which bind to the tnf-r intracellular domain have yet to be identified, so as to prevent or ameliorate an inflammatory condition
US20090092613A1Inactive Publication Date: 2009-04-09LIN LIH LING +3
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
LIN LIH LING
Publication Date
2009-04-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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Description

[0001] This application is a continuation-in-part of application Ser. No. 08 / 602,228, filed Feb. 15, 1996, which was a continuation-in-part of application Ser. No. 08 / 533,901, filed Sep. 26, 1995, which was a continuation-in-part of application Ser. No. 08 / 494,440, filed Jun. 19, 1995, which was a continuation-in-part of application Ser. No. 08 / 327,514, filed Oct. 19, 1994.BACKGROUND OF THE INVENTION

[0002] The present invention relates to the field of anti-inflammatory substances and other substances which act by inhibiting binding to the intracellular domain of a tumor necrosis factor receptor (hereinafter “TNF-R”), such as, for example, the P55 type (or TNF-R1) TNF receptor. More particularly, the present invention is directed to novel ligands which bind to the TNF-R intracellular domain and to inhibition or modulation of signal transduction by this receptor.

[0003] Tumor necrosis factor (herein “TNF”) is a cytokine which produces a wide range of cellular activities. TNF causes an inf...

Claims

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