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Plant cell lines established from the medicinal plant veratrum californicum

a technology of veratrum californicum and plant cell lines, which is applied in the direction of plant cells, biochemistry apparatus and processes, plant/algae/fungi/lichens ingredients, etc., can solve the problems of lagging the biosynthetic activity of the commercially most important secondary product, lagging the effect of wild plant substance isolation, and not always the cas

Inactive Publication Date: 2009-12-10
VLAAMS INTERUNIVERSITAIR INST VOOR BIOTECHNOLOGIE VZW +1
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Problems solved by technology

At present, Veratrum californicum is the only source for cyclopamine because the compound with its complex chemical structure cannot be synthesized at an economical price.
Isolation of the substance from wild plants is impeded by the low and highly variable quantity, and is therefore very expensive.
But in practice, this is not always the case.
This is due to the non-amenability of many plants to grow in culture.
Furthermore, of those that could be finally grown under suitable conditions, many lacked desired biosynthetic activity of the commercially most important secondary products.

Method used

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  • Plant cell lines established from the medicinal plant veratrum californicum
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  • Plant cell lines established from the medicinal plant veratrum californicum

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1. Initiation and Maintenance of Callus Cultures from Veratrum californicum

[0026]Several aspects (e.g. influence of embryo size, culture medium and growth regulators) were studied in detail in order to clarify their role in the induction of embryogenesis. For monocotyledonous plant tissue culture it is known that embryo size, indicating the physiological stage of the embryo development, plays an important role in somatic embryogenesis and is critical for the establishment of embryogenic callus. The influence of embryo size of mature seeds on somatic embryogenesis of V. californicum was studied (Table 1). Embryo size significantly affected embryogenic callus induction (P2 mm) produced significantly higher embryogenic callus yield than smaller embryos (0.05). Culture medium, providing both nutrients and an osmotic environment, is an important factor influencing somatic embryogenesis. Composition of basal medium including the carbon source, the source and amount of total nitrogen, vit...

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Abstract

The present invention relates to the field of plant secondary metabolites. More particularly plant cell lines are established from the medicinal plant Veratrum californicum. Said plant cell lines can be used for the production of cyclopamine and related steroid alkaloids and their precursors.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the field of plant secondary metabolites. More particularly plant cell lines are established from the medicinal plant Veratrum californicum. Said plant cell lines can be used for the production of cyclopamine and related steroid alkaloids and their precursors.BACKGROUND TO THE INVENTION[0002]Plants provide not only foods, but also other useful materials such as wood, cellulose, gums and rubbers. They contain a wide range of chemical compounds including pharmaceuticals, flavours, fragrance, colours and insecticides. These compounds belong to a group collectively known as secondary products or secondary metabolites. The genus Veratrum comprises up to 45 species of perennial herbs distributed throughout the northern temperate to arctic regions of Europe, Asia and North America. Its exact systematic position is still under debate but modern systems place it within the tribe Melanthieae of Melanthiaceae whereas traditionally th...

Claims

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Application Information

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IPC IPC(8): C12P33/20C12N5/04
CPCA61K36/896A01H4/00
Inventor RITALA-NURMI, ANNELIRISCHER, HEIKOOKSMAN-CALDENTEY, KIRSI-MARJARUI, MA
Owner VLAAMS INTERUNIVERSITAIR INST VOOR BIOTECHNOLOGIE VZW
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