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Composition and method for blood sugar modulation

a technology of modulation and blood sugar, applied in the direction of biocide, plant/algae/fungi/lichens, bandages, etc., can solve the problem that adults with pre-diabetes may remain in sedentary lifestyles

Active Publication Date: 2014-09-18
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent text describes a composition that can help regulate blood sugar in people with Type 2 diabetes and other metabolic disorders. The composition contains a mixture of herbal extracts and minerals, including gymnema, green coffee, grape seed, hibiscus, cinnamon, holy basil, Russian tarragon, ginger, turmeric, and chromium. The patent also provides methods for using the composition to treat or prevent these conditions by administering it to patients. The technical effect of the invention is to provide a natural and effective way to manage blood sugar levels in Type 2 diabetes and other metabolic disorders.

Problems solved by technology

Unfortunately, adults with pre-diabetes may remain in sedentary lifestyles without dietary interventions or weight loss that might mitigate risk of disease.

Method used

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  • Composition and method for blood sugar modulation
  • Composition and method for blood sugar modulation
  • Composition and method for blood sugar modulation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0072]A composition was prepared as shown in Table 1.

TABLE 1DosageIngredient(per 3 softgels)Gymnema Hydroethanolic extract400mgGreen Coffee Hydroethanolic extract100mgGrape Seed Aqueous extract100 mgHibiscus Hydroethanolic extract100 mgCinnamon100mgSupercritical Cinnamon−33mgHydroethanolic Cinnamon−67mgHoly Basil75 mgSupercritical Holy Basil −15mgHydroethanolic Holy Basil−60mgRussian Tarragon AQ extract50 mgGinger20mgSupercritical Ginger−3mgHydroethanolic Ginger−17mgTurmeric20mgSupercritical Turmeric−4mgHydroethanolic Turmeric−16mgGTF Chromium120mcg

[0073]In some embodiments, the composition can further include inactive ingredients, such as, for example, olive oil. In addition, or alternatively, the composition can be divided into one or more doses, such as, for example, a tablet, a pill, a capsule, a liquid, or a powder, such as, for example, a softgel capsule.

example 2

Intestinal Glucose Absorption

[0074]This example demonstrates that the ingredients shown in Example 1 can inhibit transport of glucose across the intestinal cell membrane.

[0075]Test solutions of the composition were prepared fresh on the day of use as described. Extracted herbal components equivalent to 3 supplements were solubilized in DMSO (2.44 ml) and centrifuged at 17,000×g for 5 min. Supernatants were combined to make an herbal concentrate and an aliquot (81 μl) was diluted by approximately 250 times to a final volume of 20 ml using transport buffer (pH 7.4). Sodium content was adjusted via the transport buffer, and 1 mM glucose and D-[U-14C] glucose (0.05 μCi / ml) was added The final test concentration was considered to be physiologically relevant, based on the dissolution of a normal serving of supplement in 600 ml of digestive juices. This volume was in line with reported combined volume of gastrointestinal fluid detected in the postprandial stomach (686±93 ml) and small inte...

example 3

Alpha-Glucosidase Inhibition

[0091]This example demonstrates that the ingredients shown in Example 1 can inhibit alpha-glucosidase activity.

[0092]Test solutions of the herbal composition (BSTC) were prepared in 10% DMSO solution prepared with PBS at a concentration of 10 mg / ml. Yeast (Saccharomyces cerevisiae) alpha-glucosidase purchased from Sigma was dissolved in 10 mM sodium phosphate buffer (pH 6.3) at a concentration of 0.01 U / ul. The reaction mixture was prepared by combining 10 ul of alpha-glucosidase (0.01 u / ul) and 1-20 ug / ml of the test composition in 100 ul of 10 mM phosphate buffer (pH 6.3). The positive control for alpha-glucosidase inhibition activity assay is Acarbose (200-2000 ug). The reaction mixture was warmed for 15 min in a water bath at 37° C. followed by the addition of 100 ul of 0.2 mM p-nitrophenyl-alpha-D-glucopyranoside (PNP) and further incubation at 37° C. for 30 min.

[0093]The reaction was stopped by incubating the tubes for 10 min at 100° C. in a boiling...

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Abstract

Compositions and methods for modulating blood sugar are provided. The composition comprises gymnema, green coffee, grape seed, hibiscus, cinnamon, holy basil, Russian tarragon, ginger, turmeric, and chromium.

Description

FIELD OF THE INVENTION[0001]The invention relates to a composition and method for blood sugar modulation.BACKGROUND OF THE INVENTION[0002]Metabolic syndrome is characterized by the presence of traditional risk factors for heart disease, such as hypertension, cholesterol disorders, blood coagulation abnormalities and obesity. Although the cause of metabolic syndrome is not specifically known, obesity and insulin resistance are generally present. The presence of insulin resistance is characteristic of both metabolic syndrome and clinical cases of diabetes, and is the primary contributor to the hypertension, lipid problems, and blood sugar abnormalities that define these conditions. Individuals with impaired fasting glucose and / or impaired glucose tolerance may be considered to have pre-diabetes based on the fact that insulin resistance is generally present, and these individuals have an elevated risk of progressing to Type 2 diabetes. Unfortunately, adults with pre-diabetes may remain...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K36/74A61K36/87A61K33/24A61K36/54A61K36/53A61K36/282A61K36/9066A61K36/27A61K36/185
CPCA61K36/9068A61K33/24A61K36/185A61K36/27A61K36/9066A61K36/53A61K36/54A61K36/74A61K36/87A61K36/282A61K2300/00A61F13/622
Inventor FORRELLI, TARYN LOUISESCHULICK, PAUL
Owner NEW CHAPTER
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