CGRP receptor antagonist

a technology of cgrp receptor and antagonist, which is applied in the direction of peptides, drug compositions, cardiovascular disorders, etc., can solve the problems of lack of molecular evidence and cgrp2 receptor

Active Publication Date: 2013-07-09
BRISTOL MYERS SQUIBB CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]The invention provides technical advantages, for example, the compound is novel and inhibits CGRP. Additionally, the compound provides advantages for pharmaceutical uses, for example, with regard to one or more of their mechanism of action, binding, inhibition efficacy, target selectivity, solubility, safety profiles, or bioavailability.

Problems solved by technology

However, there is lack of molecular evidence for the CGRP2 receptor (Brain, S. D. et al, TiPS 2002, 23, 51-53).

Method used

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Examples

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Embodiment Construction

[0009]The invention encompasses (R)—N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (Compound I or the compound of formula I) and pharmaceutical compositions and methods for modulating CGRP and treating patients with medical conditions associated with aberrant levels of CGRP or CGRP receptor signaling.

[0010]

[0011]The invention includes all pharmaceutically acceptable salt forms of the compounds. Pharmaceutically acceptable salts are those in which the counter ions do not contribute significantly to the physiological activity or toxicity of the compounds and as such function as pharmacological equivalents. These salts can be made according to common organic techniques employing commercially available reagents. Some anionic salt forms include acetate, acistrate, besylate, bromide, chloride, citrate, fumarate, glucouronate, hydrobromide, hydrochloride, hydroiodide, iodide, lactate,...

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Abstract

The disclosure generally relates to the compound of formula I, (R)—N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide, including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This patent application claims the benefit of U.S. provisional patent application No. 61 / 319,015 filed Mar. 30, 2010.BACKGROUND OF THE INVENTION[0002]The disclosure generally relates to the compound (R)—N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (Compound I or the compound of formula I), including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.[0003]Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-a...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): C07D401/14A61K31/496
CPCC07K5/0806C07D401/14A61P11/00A61P11/06A61P15/00A61P15/12A61P17/02A61P25/00A61P25/02A61P25/04A61P25/06A61P29/00A61P35/00A61P43/00A61P9/00A61K31/416A61K31/4725A61K31/496C07D403/14
Inventor CHATURVEDULA, PRASAD V.DUBOWCHIK, GENE M.MACOR, JOHN E.
Owner BRISTOL MYERS SQUIBB CO
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