Thermo-sensitive filling gel preparation for rhinology, preparation method of thermo-sensitive filling gel preparation and application of thermo-sensitive filling gel preparation in operation on nasal cavity and paranasal sinuses

A gel preparation and temperature-sensitive technology, which is applied in the field of temperature-sensitive filling gel preparations, can solve the problems of secondary wounds, removal, and difficulty in placing sponges, and achieves the advantages of preventing infection, being convenient to use, and avoiding secondary injuries. Effect

CN106178111AActive Publication Date: 2016-12-07SAIKE SAISI BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2016-12-07

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Abstract

The invention discloses a thermo-sensitive filling gel preparation for rhinology, a preparation method of the thermo-sensitive filling gel preparation and an application of the thermo-sensitive filling gel preparation in operation on nasal cavity and paranasal sinuses. The preparation comprises components in percentage by weight as follows: 3%-20% of chitosan, 0.3%-3% of cellulose, 15%-25% of poloxamer and 52%-81.7% of an alkaline buffer solution. The prepared filling gel preparation for the rhinology is thermo-sensitive and has lower viscosity when the preparation does not enter a human body, so that gel can be pushed out easily; the viscosity and adhesive power of the gel are increased due to increase of the temperature when the preparation enters the human body, thus, the gel is not prone to flowing out of the nasal cavity, the time consumed for action with the wound can be effectively prolonged, and the effectiveness of a product is improved. The preparation method is simple, the product has a good filling function in the operation on the nasal cavity and the paranasal sinuses, can effectively prevent nasal mucosa from surface adhesion, control mild bleeding, prevent infection and assist in natural healing, and can be naturally degraded or washed after 7-14 days and is convenient to use.
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Description

technical field

[0001] The invention relates to a temperature-sensitive filling gel preparation, in particular to a temperature-sensitive filling gel preparation for rhinology and a preparation method thereof, and also relates to the use of the temperature-sensitive filling gel preparation for filling after nasal cavity and sinus surgery , support, and prevent the application of adhesion on the surface of the nasal mucosa. Background technique

[0002] Chronic rhinitis is a common and high-incidence disease in humans. According to the statistics of national ENT experts, the incidence rate of chronic rhinitis in the country is as high as 37%. Corresponding treatment methods and medicines make it still use the general anti-inflammatory treatment in the past when it is treated clinically, and good curative effect cannot be obtained. Rhinitis is by no means a general inflammation, but a kind of "non-specific tissue rhinitis". Conventional anti-inflammatory treatment will not ac...

Examples

preparation example Construction

[0041] The preparation method of the nasal temperature-sensitive filling gel preparation of the present invention is simple, comprising the following steps:

[0042] (1) Mix the alkaline buffer system and chitosan evenly, then add cellulose and poloxamer thereto under stirring, and fully stir;

[0043] (2) The mixture was allowed to stand at room temperature until fully swollen, and then sterilized to obtain a thermosensitive filling gel preparation for nasal use.

[0044] In the above method, the alkaline buffer system is prepared according to the formula first, then the chitosan and the alkaline buffer system are mixed evenly, and then the cellulose and poloxamer are added under stirring, and stirred until they are fully dispersed and dissolved.

[0045] In the above step (2), the mixture was allowed to stand at room temperature for 72-100 hours to fully swell.

[0046] In the above-mentioned step (2), after the mixture is swollen, any method used in industry can be used fo...

Embodiment 1

[0050] The formulation of the nasal thermosensitive filling gel preparation is: 3% chitosan hydrochloride with a molecular weight of 400KDa, 0.3% hydroxypropyl cellulose, 15% poloxamer 407, and 81.7% alkaline buffer system. Among them, the alkaline buffer system is a phosphate buffer with a pH of 8. The buffer components and their contents in the gel preparation are: potassium dihydrogen phosphate 0.04%, disodium hydrogen phosphate 0.45%, sodium chloride 2%, chlorine Potassium chloride 0.06%, sodium hydroxide 0.01%, polyethylene glycol 4000.8%, water 78.34%.

[0051] The preparation method of thermosensitive rhinology filling gel preparation is:

[0052] (1) take each required raw material respectively by formula;

[0053] (2) mixing the components of the alkaline buffer system according to the proportions to form an alkaline buffer system;

[0054] (3) chitosan hydrochloride is added in the alkaline buffer system and stirred evenly;

[0055] (4) Add hydroxypropyl cellulose...

Embodiment 2

[0059]The formula of thermosensitive filling gel preparation for nose is: chitosan acetate with a molecular weight of 400KDa 6%, hydroxypropyl cellulose 0.6%, carboxymethyl cellulose 0.2%, poloxamer 40719%, alkali Sexual buffer system 74.2%. Among them, the alkaline buffer system is a phosphate buffer with a pH of 9. The buffer components and their contents in the gel preparation are: potassium dihydrogen phosphate 0.06%, disodium hydrogen phosphate 0.54%, sodium chloride 3.0%, chlorine Potassium chloride 0.10%, sodium hydroxide 0.05%, propylene glycol 1.5%, water 68.95%.

[0060] Referring to Example 1 for the preparation method, the pH of the obtained nasal temperature-sensitive filling gel preparation is 7.5.