107 results about "Motherisk" patented technology

The invention relates to a detection method performed on a maternal serum or plasma sample from a pregnant female, which method comprises detecting the presence of a nucleic acid of foetal origin in the sample. The invention enables non-invasive prenatal diagnosis including for example sex determination, blood typing and other genotyping, and detection of pre-eclampsia in the mother.

A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a mother's abdomen. Processing is performed to extract absorption information related to fetal arterial blood with calculation of fetal oxygen saturation from the extracted data.

The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.

The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.

A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and / or genetic data taken from other related individuals.

A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and / or genetic data taken from other related individuals.

A continuous, non-invasive fetal heart rate measurement is produced using one or more ultrasonic transducer array patches that are adhered or attached to the mother. Each ultrasound transducer array is operated in an autonomous mode by a digital signal processor to obtain data from which fetal heart rate information can be derived. Each ultrasonic transducer array patch comprises a multiplicity of subelements that are switchably reconfigurable to form elements having different shapes, e.g., annular rings. Each subelement comprises a plurality of interconnected cMUT cells that are not switchably disconnectable. The use of cMUT patches will provide the ability to interrogate a three-dimensional space electronically (i.e. without mechanical beam steering) with ultrasound, using a transducer device that is thin and lightweight enough to stick to the patient's skin like an EKG electrode. The ultrasound device can track the fetal heart in three-dimensional space as it moves due to the mother's motion or the motion of the unborn child within the womb.

The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.

Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal / tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother / patient. A methylation profile can be determined for fetal / tumor tissue using tissue-specific alleles to identify DNA from the fetus / tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus / tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

To provide an information notification apparatus which includes: a rule management unit (103) which holds (a) an information notification rule generated based on the information (TPO information) concerning the preference of a specific user (mother), the rule defining that predetermined information (“Buy milk.”) should be notified to the user (mother) in the case where the user (mother) satisfies predetermined conditions (“Milk is on sale nearby.” and “I have 500 yen or more.”) and (b) an information notification rule which is generated based on the information concerning the preference of another user (father); and a rule execution unit (107) which notifies the user (mother) of the information (“Buy local sake.”) to be notified to another user (father) in the case where the conditions (“Local sake, which is rice wine, is on sale nearby.” and “It costs 2000 yen or less.”) which are defined by the information notification rule concerning another user (father) is satisfied by the user (mother).

A method, system, and computer program product are provide for, among other things, quantitative analysis of heart rate characteristics from fetal heart rate and cardiotocogram monitors that gives information about the well-being of the fetus and the risk of poor fetal outcome. The method comprises (a) continuously measuring fetal heart rate and cardiotocographic characteristics and (b) identifying at least one characteristic abnormality in the heart rate characteristics that is associated with fetal distress. Benefits are appreciated by the fetus and the mother and during the antepartum and intrapartum periods.

The invention discloses an electronic partogram system and a parameter calculating method based on a magnetic field tracing and positioning technology. The electronic partogram system comprises a magnetic field tracing and positioning module, an ultrasonic image module, a fetal heart rate and uterus shrink pressure module and an electronic partogram workstation. The magnetic field tracing and positioning module comprises a magnetic field generation device for generating a magnetic field and a magnetic induction sensor. According to the invention, through monitoring parameters such as a fetal head position, a fetal head direction, cervical dilatation, a fetal heart rate, uterus shrink pressure in a delivery process, an electronic partogram can be full-automatically or semi-automatically generated on a measuring time point, so that a doctor can dynamically monitor the delivery process through the electronic partogram. Simultaneously, due to the utilization of a full-automatic parameter calculating operation mode and a semi-automatic parameter calculating operation mode, through monitoring fetal head parameters and pelvis parameters, pelvic disproportion can be forecasted on the measuring time point; and through monitoring the fetal heart rate and the uterus shrink pressure of a mother / a fetus, multi-parameter monitoring is realized.

Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.

The invention relates to a maternal and infant management system, in particular to a real-time positioning maternal and infant management system based on the radio frequency identification (RFID) technology. The system comprises wrist band electronic labels, a fixed RFID reader, a hand-held RFID reader and a server, wherein the RFID readers are communicated with the server through an RJ45 port or a wireless network. Both the maternal and the infant wear the wrist band labels, medical personnel can read the information of the maternal and the infant through the hand-held RFID readers, the fixed RFID reader is arranged in a sickroom and a passage, the label information can be read in real time, and the positioning can be realized. The system has the beneficial effects that the maternal and infant pairing and the infant positioning problem can be solved, and the security assurance of the maternal and the infant is realized.

A system for monitoring a fetus in a pregnant woman, and / or the maternal health risk for pregnancies complicated by such as pre-eclampsia and hypertensive disorders is configured to be worn by the pregnant woman, preferably so as to allow monitoring during daily life, e.g. in the form of an adhesive patch. The unit has a sound sensor, e.g. a microphone or accelerometer, to be positioned on the skin of the abdominal area so as to detect a vascular sound from umbilical arteries of the fetus or from the uterine arteries of the pregnant woman. The sound sensor is functionally connected to a processing unit which executes a processing algorithm on the captured vascular sound and extracts a signal parameter accordingly. The processing unit then communicates the signal parameter, e.g. using an audio signal, a visual display or by means of a wired or a wireless data signal.

The present invention is a test kit comprising a plurality of individually-sealed test strips, each for detecting the presence and intensity of alcohol in breast milk. Each test strip is formed from a porous (absorbent) carrier matrix, and a color-change reagent resident on the carrier matrix. The color-change reagent comprises an alcohol oxidase enzyme and a hydrogen donor indicator that changes color when oxidized. In addition, a comparative color chart is provided, including a plurality of color swatches, a numerical scale of blood alcohol concentration, and a quantitative safe / not safe warning. The reagent on the test strip indicates the presence of alcohol in breast milk. The test kit includes a number of test strips and a color chart to allow breast feeding mothers to ascertain the concentration of alcohol in their breast milk to ensure that breast milk fed to infants is free of alcohol.

The present disclosure generally relates to personalized nutritional compositions for pediatric subjects, wherein the nutritional composition can include one of three distinct profiles of human milk oligosaccharides (HMOs). The present disclosure also relates to methods for determining the composition of HMOs present in or that would be present in the breast milk of the mother of a pediatric subject as determined by the mother's secretor status and / or Lewis blood group, and providing to the pediatric subject a nutritional composition comprising an HMO profile most similar to the HMOs present or that would be present in the breast milk of the subject's mother.

An easy-access bassinet especially useful for new mothers and babies, either in hospitals or at home. The bassinet has a barrier to prevent the infant from rolling off a sleeping platform, and one wall of the barrier is convertible to permit a mother to reach in and cradle the infant, for breast-feeding for example. The convertible wall may have a restoring mechanism to transform it back to its original barrier position upon removal of the weight of the mother's arms, or may be detachable. The convertible wall may be rigid adjacent the sleeping platform that lowers or pivots out of the way, or a mesh or fabric panel that may be depressed downward. A partial barrier wall may also be provided just inside the convertible front wall for extra security. The mesh or fabric panel is easily detached for cleaning or replacement.

Methods, apparatuses, and system are provided for analyzing a maternal sample to determine whether a male fetus of a pregnant female has inherited an X-linked mutation from the mother. A percentage of fetal DNA in the sample is obtained, and cutoff values for the two possibilities (fetus inherits mutant or normal allele) are determined. A proportion of mutant alleles relative to a normal allele on the X-chromosome can then be compared to the cutoff values to make a classification of which allele is inherited. Alternatively, a number of alleles from a target region on the X-chromosome can be compared to a number of alleles from a reference region on the X-chromosome to identify a deletion or amplification. The fetal DNA percentage can be computed by counting reactions with a fetal-specific allele, and correcting the number to account for a statistical distribution among the reactions.

The invention discloses a newborn baby transporter. The newborn baby transporter comprises a carrying case, wherein a swinging bed is arranged in the carrying case, multiple groups of sliding columnsare arranged on front and rear end faces of the swinging bed, and sliding grooves matched with the sliding columns are formed in internal walls of the carrying case; and the swinging bed is connectedwith a reciprocating driving mechanism for driving the swinging bed to swing back and forth. According to the newborn baby transporter, through arranging the swinging bed, the sliding columns, the sliding grooves and the reciprocating driving mechanism for driving the swinging bed to swing back and forth, a newborn baby can be in a swing state during transporting, and a mother's embrace is simulated, so that the newborn baby can conveniently fall asleep, and the transporting of the newborn baby is facilitated.

In the method according to the invention a phonocardiographic signal, obtained by a passive acoustic sensor (10) from a maternal abdominal wall, is pre-filtered, amplified, digitized, digitally filtered by means of a programmable amplifier and filter unit (20), is stored in an intermediate memory and autocorrelation is performed by means of an autocorrelation unit (30) in a time window of a predetermined size. The signals obtained as a result of autocorrelation are fed to an input of a fuzzy expert system (40), wherein local maximums of the signals, temporal location of the local maximums and variation of the temporal location of the local maximums are determined by the fuzzy expert system (40), and, applying those as input parameters or signals of the fuzzy expert system, those are classified into probability groups utilizing a fuzzy rule set of a decision logic stored in a knowledge base and biologically expected data and are evaluated.

High throughput sequencing has facilitated a precipitous drop in the cost of whole genome human DNA sequencing, prompting predictions of a revolution in medicine via personalization of diagnostic and therapeutic strategies to individual genetics. Disclosed is a comprehensive series of methods for identification of genetic variants and medical genotypes, phasing genetic data and using Mendelian inheritance for quality control, and providing predictive genetic information about risk for rare disease phenotypes and response to pharmacological therapy in single individuals and father-mother-child trios.

An elongated garment to support a pregnant mother and her unborn baby in utero is provided. The elongated garment may be dimensioned and adapted to lift the abdominal area of the pregnant wearer, support the hip area of the pregnant woman, reduce pelvic floor pressure and low back strain. The elongated garment is also adapted to provide a plurality of safe-decibel audio output which may be used with any media device, with pockets specifically positioned inside said garment used on the abdominal area so as to help guide her unborn baby into a head-down orientation in preparation of birth.The elongated garment is also adapted to provide postpartum support of a new mother's hips and abdominal muscles. The elongated garment may be used to assist with postpartum recovery. The speakers are used by peeling and placing on a newborn baby's crib or stroller to provide audio output which may be used with any media device, playing music which was played prenatally which has been proven to help calm newborn infants post birth.

Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.

The invention relates to a control system and method for achieving mother and infant safety management through automatic pairing, and relates to the technical field of infant theft prevention. The control system comprises an infant bracelet, a mother bracelet and a nurse bracelet, wherein the infant bracelet is provided with a first transceiving module, a first sensor and a control module; the mother bracelet is provided with a second transceiving module, and the second transceiving module further comprises a first integrated voice chip; the nurse bracelet is provided with a third transceiving module; the third transceiving module further comprises a second integrated voice chip; the first sensor is used for acquiring real-time position information of the infant bracelet; and the control module is used for controlling the first transceiving module according to the real-time position information collected by the first sensor so as to send the real-time position information to the second transceiving module and the third transceiving module. According to the control system and method provided by the invention, the phenomenon that the infant is taken by mistake can be avoided.

The invention discloses a microhaplotype genetic marker combination and method for noninvasive prenatal paternity relationship judgment. The microhaplotype genetic marker combination for noninvasive prenatal paternity relationship judgment is provided firstly; and a calculation model of a fetal paternity index (PI) is built based on a Bayesian principle according to a sequencing result in combination with a high-throughput sequencing technology by taking microhaplotypes uniformly distributed on autosomes as genetic markers so as to judge a prenatal paternity relationship of gemellary pregnancy. According to the method, only 10ml of peripheral blood of a mother needs to be provided, and free DNA extracted from peripheral plasma of the mother already contains free DNA of a fetus, so that themother and the fetus only need one sample. Because only the venous blood of the pregnant woman needs to be extracted, the operation is simple and convenient, and the pregnant woman and the fetus cannot be wounded; and identification can be carried out after 7 weeks of pregnancy, and a detection result is consistent with that of a conventional STR typing method, so that the application prospect isrelatively great.