97 results about "Motherisk" patented technology

The invention relates to a detection method performed on a maternal serum or plasma sample from a pregnant female, which method comprises detecting the presence of a nucleic acid of foetal origin in the sample. The invention enables non-invasive prenatal diagnosis including for example sex determination, blood typing and other genotyping, and detection of pre-eclampsia in the mother.

A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a mother's abdomen. Processing is performed to extract absorption information related to fetal arterial blood with calculation of fetal oxygen saturation from the extracted data.

A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.

A continuous, non-invasive fetal heart rate measurement is produced using one or more ultrasonic transducer array patches that are adhered or attached to the mother. Each ultrasound transducer array is operated in an autonomous mode by a digital signal processor to obtain data from which fetal heart rate information can be derived. Each ultrasonic transducer array patch comprises a multiplicity of subelements that are switchably reconfigurable to form elements having different shapes, e.g., annular rings. Each subelement comprises a plurality of interconnected cMUT cells that are not switchably disconnectable. The use of cMUT patches will provide the ability to interrogate a three-dimensional space electronically (i.e. without mechanical beam steering) with ultrasound, using a transducer device that is thin and lightweight enough to stick to the patient's skin like an EKG electrode. The ultrasound device can track the fetal heart in three-dimensional space as it moves due to the mother's motion or the motion of the unborn child within the womb.

Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

To provide an information notification apparatus which includes: a rule management unit (103) which holds (a) an information notification rule generated based on the information (TPO information) concerning the preference of a specific user (mother), the rule defining that predetermined information (“Buy milk.”) should be notified to the user (mother) in the case where the user (mother) satisfies predetermined conditions (“Milk is on sale nearby.” and “I have 500 yen or more.”) and (b) an information notification rule which is generated based on the information concerning the preference of another user (father); and a rule execution unit (107) which notifies the user (mother) of the information (“Buy local sake.”) to be notified to another user (father) in the case where the conditions (“Local sake, which is rice wine, is on sale nearby.” and “It costs 2000 yen or less.”) which are defined by the information notification rule concerning another user (father) is satisfied by the user (mother).

The invention discloses an electronic partogram system and a parameter calculating method based on a magnetic field tracing and positioning technology. The electronic partogram system comprises a magnetic field tracing and positioning module, an ultrasonic image module, a fetal heart rate and uterus shrink pressure module and an electronic partogram workstation. The magnetic field tracing and positioning module comprises a magnetic field generation device for generating a magnetic field and a magnetic induction sensor. According to the invention, through monitoring parameters such as a fetal head position, a fetal head direction, cervical dilatation, a fetal heart rate, uterus shrink pressure in a delivery process, an electronic partogram can be full-automatically or semi-automatically generated on a measuring time point, so that a doctor can dynamically monitor the delivery process through the electronic partogram. Simultaneously, due to the utilization of a full-automatic parameter calculating operation mode and a semi-automatic parameter calculating operation mode, through monitoring fetal head parameters and pelvis parameters, pelvic disproportion can be forecasted on the measuring time point; and through monitoring the fetal heart rate and the uterus shrink pressure of a mother/ a fetus, multi-parameter monitoring is realized.

The invention relates to a maternal and infant management system, in particular to a real-time positioning maternal and infant management system based on the radio frequency identification (RFID) technology. The system comprises wrist band electronic labels, a fixed RFID reader, a hand-held RFID reader and a server, wherein the RFID readers are communicated with the server through an RJ45 port or a wireless network. Both the maternal and the infant wear the wrist band labels, medical personnel can read the information of the maternal and the infant through the hand-held RFID readers, the fixed RFID reader is arranged in a sickroom and a passage, the label information can be read in real time, and the positioning can be realized. The system has the beneficial effects that the maternal and infant pairing and the infant positioning problem can be solved, and the security assurance of the maternal and the infant is realized.

An easy-access bassinet especially useful for new mothers and babies, either in hospitals or at home. The bassinet has a barrier to prevent the infant from rolling off a sleeping platform, and one wall of the barrier is convertible to permit a mother to reach in and cradle the infant, for breast-feeding for example. The convertible wall may have a restoring mechanism to transform it back to its original barrier position upon removal of the weight of the mother's arms, or may be detachable. The convertible wall may be rigid adjacent the sleeping platform that lowers or pivots out of the way, or a mesh or fabric panel that may be depressed downward. A partial barrier wall may also be provided just inside the convertible front wall for extra security. The mesh or fabric panel is easily detached for cleaning or replacement.

The invention discloses a newborn baby transporter. The newborn baby transporter comprises a carrying case, wherein a swinging bed is arranged in the carrying case, multiple groups of sliding columnsare arranged on front and rear end faces of the swinging bed, and sliding grooves matched with the sliding columns are formed in internal walls of the carrying case; and the swinging bed is connectedwith a reciprocating driving mechanism for driving the swinging bed to swing back and forth. According to the newborn baby transporter, through arranging the swinging bed, the sliding columns, the sliding grooves and the reciprocating driving mechanism for driving the swinging bed to swing back and forth, a newborn baby can be in a swing state during transporting, and a mother's embrace is simulated, so that the newborn baby can conveniently fall asleep, and the transporting of the newborn baby is facilitated.

In the method according to the invention a phonocardiographic signal, obtained by a passive acoustic sensor (10) from a maternal abdominal wall, is pre-filtered, amplified, digitized, digitally filtered by means of a programmable amplifier and filter unit (20), is stored in an intermediate memory and autocorrelation is performed by means of an autocorrelation unit (30) in a time window of a predetermined size. The signals obtained as a result of autocorrelation are fed to an input of a fuzzy expert system (40), wherein local maximums of the signals, temporal location of the local maximums and variation of the temporal location of the local maximums are determined by the fuzzy expert system (40), and, applying those as input parameters or signals of the fuzzy expert system, those are classified into probability groups utilizing a fuzzy rule set of a decision logic stored in a knowledge base and biologically expected data and are evaluated.

The invention discloses a microhaplotype genetic marker combination and method for noninvasive prenatal paternity relationship judgment. The microhaplotype genetic marker combination for noninvasive prenatal paternity relationship judgment is provided firstly; and a calculation model of a fetal paternity index (PI) is built based on a Bayesian principle according to a sequencing result in combination with a high-throughput sequencing technology by taking microhaplotypes uniformly distributed on autosomes as genetic markers so as to judge a prenatal paternity relationship of gemellary pregnancy. According to the method, only 10ml of peripheral blood of a mother needs to be provided, and free DNA extracted from peripheral plasma of the mother already contains free DNA of a fetus, so that themother and the fetus only need one sample. Because only the venous blood of the pregnant woman needs to be extracted, the operation is simple and convenient, and the pregnant woman and the fetus cannot be wounded; and identification can be carried out after 7 weeks of pregnancy, and a detection result is consistent with that of a conventional STR typing method, so that the application prospect isrelatively great.

The invention provides a fetal concentration quantification method and device and a fetal genotyping method and device. The fetal concentration quantification method comprises the following steps: acquiring sequencing data containing a plurality of SNP sites; recording the mutation frequencies of all SNP sites in the sequencing data, and classifying the SNP sites with the mutation frequency of 1%-25% into a first type of frequency, and classifying the SNP sites with the mutation frequency of 75%-99% into a second type of frequency, wherein the second type of frequency is equal to 1-mutation frequency; calculating a median or a mean value of a data set formed by the two frequencies, wherein the median or the mean value is twice of the median or the mean value to obtain the fetal concentration. Based on differential SNP sites of fetuses and maternal bodies, the fetal concentrations of the male fetus and the female fetus are accurately quantified, and then whether the fetus inherits mutation from the mother or the father under the background of mother mutation or not can be accurately detected in combination with the maternal background provided by the leukocyte sample of the pregnantwoman, so the problem that fetal genotyping is difficult to perform under the background of maternal mutation is solved.

The present invention is focused on an in vitro method for identifying or screening human subjects at risk of suffering from a pregnancy related disease, in particular from gestational diabetes mellitus or preeclampsia, departing from the level of expression or concentration of a series of biomarkers isolated from a minimally-invasive sample such as gingival crevicular fluid (GCF). Moreover, the method of the invention offers high sensitivity and specificity at an early stage of the pregnancy (see the Examples and figures shown below), which means that it is a strong and cost-effective method for the detection of a pregnancy related disease, in particular gestational diabetes mellitus or preeclampsia, at an early stage of the disease thus procuring effective treatment, avoiding significant long-term adverse effects for both mother and baby.

An intelligent baby caring method and arrangement helps to recognize and maintain emotional interaction between mother and her baby and to improve the baby's life rhythm and calm and soothe him/her automatically when needed and help him/her to fall asleep and to wake up at the most convenient time and way. The aim is to help the mother with her baby to find optimal life and care rhythm. The invention is focused on a platform (101) with many sensors, sensor sheet (120), a transducer to produce acoustic and mechanical vibrations (14) and an airflow blower (132). Sensors are also fixed to the mother (10) and in the care room (198). A sleep/activity graph of the baby and sleep/emotion graph of the mother are measured and tracked with multimodal sensors and an artificial intelligence unit (200) processes audio, motion and airflow actions given to the baby from the platform to help the baby to move from an improper to optimal sleep/activity level.

The invention relates to a method for identifying prenatal parental power relationship. Through cyclization amplification enlargement, only peripheral 10ul-1.2ml of plasma of a mother needs to be provided, and free DNA extracted from the peripheral plasma of the mother always contains free DNA of a foetus, so that only one part of samples of the mother and the foetus can be needed. Only the veinalblood of a pregnant woman needs to be extracted, the operation is simple and convenient, and the blood volume is small, so that the pregnant woman and the foetus cannot be damaged, and identificationcan be performed after pregnancy for 10 weeks.